Superoxide Radical Production Stimulates Retroocular Fibroblast Proliferation in Graves' Ophthalmopathy

Retroocular fibroblast proliferation is believed to be a key component in the pathogenesis of Graves' ophthalmopathy. In the present study, we assessed the ability of superoxide radicals, generated using the xanthine oxidase/hypoxanthine system to induce cellular proliferation in cultured human...

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Veröffentlicht in:	Experimental eye research 1997-08, Vol.65 (2), p.311-316
Hauptverfasser:	BURCH, HENRY B, LAHIRI, SABITA, BAHN, REBECCA S, BARNES, SUSAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopurinol - pharmacology Analysis of Variance Antioxidants - pharmacology Antithyroid Agents - pharmacology autoimmunity Biological and medical sciences Cell Division - drug effects cigarette smoking Connective Tissue - metabolism Connective Tissue - pathology Dose-Response Relationship, Drug Endocrinopathies Enzyme Inhibitors - pharmacology Fibroblasts - metabolism Fibroblasts - pathology Graves Disease - metabolism Graves Disease - pathology Graves' disease Humans Medical sciences Methimazole - pharmacology Niacinamide - pharmacology Non tumoral diseases. Target tissue resistance. Benign neoplasms ophthalmopathy oxidative damage pathogenesis Reactive Oxygen Species - metabolism retroocular fibroblast Smoking - adverse effects superoxide dismutase superoxide radical Superoxides - metabolism thyroid Thyroid. Thyroid axis (diseases) Xanthine Oxidase - antagonists & inhibitors
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