HYDROXYLATION AND N-DEMETHYLATION OF CLARITHROMYCIN (6-O-METHYLERYTHROMYCIN A) BY MUCOR CIRCINELLOIDES

In the course of studying the metabolism of clarithromycin (1, 6-O-methylerythromycin A, TE-031), (14R)-14-hydroxyclarithromycin (2) was isolated from human urine as a major and an active metabolite. For further pharmacological and toxicological studies on this metabolite, the authors obtained a sig...

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Veröffentlicht in:	Journal of antibiotics 1989/09/25, Vol.42(9), pp.1433-1437
Hauptverfasser:	ADACHI, TAKASHI, SASAKI, JOJI, OMURA, SADAFUMI
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Chemical Phenomena Chemistry Clarithromycin Erythromycin - analogs & derivatives Erythromycin - isolation & purification Erythromycin - metabolism Erythromycin - pharmacology Gram-Positive Bacteria - drug effects Hydroxylation Medical sciences Microbial Sensitivity Tests Mucor - metabolism Pharmacology. Drug treatments Structure-Activity Relationship
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