Pharmacokinetics of ampicillin, sulbactam and cefotiam in patients undergoing orthopedic surgery

As perioperative prophylaxis for major orthopedic operations 81 patients were given the fixed combination of ampicillin (1 g)/sulbactam (0.5 g) or cefotiam (2 g) as short infusions. The three beta-lactams were rapidly distributed into the different tissues and their pharmacokinetic profiles were fou...

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Veröffentlicht in:	Infection 1997-07, Vol.25 (4), p.258-262
Hauptverfasser:	WILDFEUER, A, MALLWITZ, J, GOTTHARDT, H, HILLE, E, GRUBER, H, DAHMEN, G, PFAFF, G, GÖBEL, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Ampicillin - pharmacokinetics Ampicillin - therapeutic use Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Antibiotic Prophylaxis Biological and medical sciences Cefotiam - pharmacokinetics Cefotiam - therapeutic use Drug Administration Schedule Female Hip Prosthesis - adverse effects Humans Infusions, Intravenous Knee Prosthesis - adverse effects Male Medical sciences Middle Aged Orthopedic surgery Prosthesis-Related Infections - etiology Prosthesis-Related Infections - prevention & control Sulbactam - pharmacokinetics Sulbactam - therapeutic use Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Treatment Outcome
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