Minimal residual disease detection in B-cell malignancies by assessing IgH rearrangement

In B-cell malignancies, the uniqueness of the immunoglobulin heavy chain locus (IgH) clonal rearrangement provides a useful marker for the detection of minimal residual disease (MRD) after treatment. During the last decade, several techniques have been proposed and used for detecting MRD. In this re...

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Veröffentlicht in:	Hematology and cell therapy 1997-06, Vol.39 (3), p.119-124
Hauptverfasser:	MALOUM, K, PRITSCH, O, DIGHIERO, G
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - pathology Biological and medical sciences Gene Rearrangement, B-Lymphocyte, Heavy Chain - genetics Gene Rearrangement, B-Lymphocyte, Heavy Chain - physiology Hematology Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - physiology Investigative techniques, diagnostic techniques (general aspects) Leukemia, Lymphocytic, Chronic, B-Cell - genetics Lymphoma, B-Cell - genetics Medical sciences Neoplasm, Residual - diagnosis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
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