The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin
We studied the effect of intravenous (i.v.) adminisration of 200 mg of iron sucrose following an i.v. bolus injection of recombinant human erythropoietin (r‐HuEPO; 300 U/kg body weight) in seven subjects and compared it with seven subjects treated with r‐HuEPO alone. Reticulocytes, serum erythropoie...
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| Veröffentlicht in: | British journal of haematology 1997-08, Vol.98 (2), p.292-294 |
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| creator | Major, Attila Mathez‐Loic, Fabien Rohling, Roman Gautschi, Kurt Brugnara, Carlo |
| description | We studied the effect of intravenous (i.v.) adminisration of 200 mg of iron sucrose following an i.v. bolus injection of recombinant human erythropoietin (r‐HuEPO; 300 U/kg body weight) in seven subjects and compared it with seven subjects treated with r‐HuEPO alone. Reticulocytes, serum erythropoietin (EPO) and ferritin levels were studied at baseline and daily for the following 8 d. Use of i.v. iron abolished the marked reduction in serum ferritin observed with r‐HuEPO administration. Although the total number of reticulocytes was not affected by i.v. iron administration, the reticulocyte Hb content and retHb (a measure in g/l of the Hb contained in all reticulocytes) were increased in the i.v. iron/r‐HuEPO group compared with the group who received r‐HuEPO alone. Therefore i.v. iron significantly potentiates the haemopoietic response to r‐HuEPO in normal subjects. |
| doi_str_mv | 10.1046/j.1365-2141.1997.2123031.x |
| format | Article |
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Reticulocytes, serum erythropoietin (EPO) and ferritin levels were studied at baseline and daily for the following 8 d. Use of i.v. iron abolished the marked reduction in serum ferritin observed with r‐HuEPO administration. Although the total number of reticulocytes was not affected by i.v. iron administration, the reticulocyte Hb content and retHb (a measure in g/l of the Hb contained in all reticulocytes) were increased in the i.v. iron/r‐HuEPO group compared with the group who received r‐HuEPO alone. Therefore i.v. iron significantly potentiates the haemopoietic response to r‐HuEPO in normal subjects.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.1997.2123031.x</identifier><identifier>PMID: 9266922</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; anaemia ; Anemia, Iron-Deficiency - blood ; Anemia, Iron-Deficiency - therapy ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; erythropoietin ; Erythropoietin - therapeutic use ; Female ; Ferritins - metabolism ; Hemoglobins - metabolism ; Humans ; Injections, Intravenous ; iron ; Iron - administration & dosage ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Recombinant Proteins - therapeutic use ; Reticulocyte Count ; reticulocytes ; Reticulocytes - physiology ; therapy</subject><ispartof>British journal of haematology, 1997-08, Vol.98 (2), p.292-294</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4502-cbf76f826fca245c705899da3f526baad6c5544fb241edb7d0f9fd7b24c9a7f23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2141.1997.2123031.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2141.1997.2123031.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2772157$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9266922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Major, Attila</creatorcontrib><creatorcontrib>Mathez‐Loic, Fabien</creatorcontrib><creatorcontrib>Rohling, Roman</creatorcontrib><creatorcontrib>Gautschi, Kurt</creatorcontrib><creatorcontrib>Brugnara, Carlo</creatorcontrib><title>The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>We studied the effect of intravenous (i.v.) adminisration of 200 mg of iron sucrose following an i.v. bolus injection of recombinant human erythropoietin (r‐HuEPO; 300 U/kg body weight) in seven subjects and compared it with seven subjects treated with r‐HuEPO alone. Reticulocytes, serum erythropoietin (EPO) and ferritin levels were studied at baseline and daily for the following 8 d. Use of i.v. iron abolished the marked reduction in serum ferritin observed with r‐HuEPO administration. Although the total number of reticulocytes was not affected by i.v. iron administration, the reticulocyte Hb content and retHb (a measure in g/l of the Hb contained in all reticulocytes) were increased in the i.v. iron/r‐HuEPO group compared with the group who received r‐HuEPO alone. Therefore i.v. iron significantly potentiates the haemopoietic response to r‐HuEPO in normal subjects.</description><subject>Adult</subject><subject>anaemia</subject><subject>Anemia, Iron-Deficiency - blood</subject><subject>Anemia, Iron-Deficiency - therapy</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>erythropoietin</subject><subject>Erythropoietin - therapeutic use</subject><subject>Female</subject><subject>Ferritins - metabolism</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>iron</subject><subject>Iron - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Reticulocyte Count</subject><subject>reticulocytes</subject><subject>Reticulocytes - physiology</subject><subject>therapy</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkNFLxCAcxyWKuq7-hGBE9Lalbs5bD0Ed1RVBL_Uszinnsemlrtp_n-PGvQeCfvl-v-rvA8AlghmCRXmzyVBekhSjAmWoqmiGEc5hjrLfAzDbW4dgBiGkaawsTsCp9xsIUQ4JOgbHFS7LCuMZYB9rmUilpAiJVYk2wfFvaWzvE-2sSeIKMeFk0KJvrRjCKPzWGi-TYONZ2K7WhpuQrPuOm0S6Iayd3VodO-YMHCneenk-7XPw-fT4sVylb-_PL8v7t1QUBOJU1IqWaoFLJTguiKCQLKqq4bkiuKw5b0pBSFGoGhdINjVtoKpUQ6MUFacK53Nwvbt36-xXL31gnfZCti03Mg7DaJyWQljE4O0uKJz13knFtk533A0MQTbSZRs2ImQjQjbSZRNd9hvLF9Mrfd3JZl-dcEb_avK5F7xVjhuh_T6GKcWI0Bi728V-dCuHf3yAPbyuRvEH50qX4A</recordid><startdate>199708</startdate><enddate>199708</enddate><creator>Major, Attila</creator><creator>Mathez‐Loic, Fabien</creator><creator>Rohling, Roman</creator><creator>Gautschi, Kurt</creator><creator>Brugnara, Carlo</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199708</creationdate><title>The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin</title><author>Major, Attila ; Mathez‐Loic, Fabien ; Rohling, Roman ; Gautschi, Kurt ; Brugnara, Carlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4502-cbf76f826fca245c705899da3f526baad6c5544fb241edb7d0f9fd7b24c9a7f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>anaemia</topic><topic>Anemia, Iron-Deficiency - blood</topic><topic>Anemia, Iron-Deficiency - therapy</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>erythropoietin</topic><topic>Erythropoietin - therapeutic use</topic><topic>Female</topic><topic>Ferritins - metabolism</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>iron</topic><topic>Iron - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Recombinant Proteins - therapeutic use</topic><topic>Reticulocyte Count</topic><topic>reticulocytes</topic><topic>Reticulocytes - physiology</topic><topic>therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Major, Attila</creatorcontrib><creatorcontrib>Mathez‐Loic, Fabien</creatorcontrib><creatorcontrib>Rohling, Roman</creatorcontrib><creatorcontrib>Gautschi, Kurt</creatorcontrib><creatorcontrib>Brugnara, Carlo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Major, Attila</au><au>Mathez‐Loic, Fabien</au><au>Rohling, Roman</au><au>Gautschi, Kurt</au><au>Brugnara, Carlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>1997-08</date><risdate>1997</risdate><volume>98</volume><issue>2</issue><spage>292</spage><epage>294</epage><pages>292-294</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>We studied the effect of intravenous (i.v.) adminisration of 200 mg of iron sucrose following an i.v. bolus injection of recombinant human erythropoietin (r‐HuEPO; 300 U/kg body weight) in seven subjects and compared it with seven subjects treated with r‐HuEPO alone. Reticulocytes, serum erythropoietin (EPO) and ferritin levels were studied at baseline and daily for the following 8 d. Use of i.v. iron abolished the marked reduction in serum ferritin observed with r‐HuEPO administration. Although the total number of reticulocytes was not affected by i.v. iron administration, the reticulocyte Hb content and retHb (a measure in g/l of the Hb contained in all reticulocytes) were increased in the i.v. iron/r‐HuEPO group compared with the group who received r‐HuEPO alone. Therefore i.v. iron significantly potentiates the haemopoietic response to r‐HuEPO in normal subjects.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9266922</pmid><doi>10.1046/j.1365-2141.1997.2123031.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of haematology, 1997-08, Vol.98 (2), p.292-294 |
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| subjects | Adult anaemia Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - therapy Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system erythropoietin Erythropoietin - therapeutic use Female Ferritins - metabolism Hemoglobins - metabolism Humans Injections, Intravenous iron Iron - administration & dosage Male Medical sciences Pharmacology. Drug treatments Recombinant Proteins - therapeutic use Reticulocyte Count reticulocytes Reticulocytes - physiology therapy |
| title | The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin |
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