Gut Decontamination Reduces Bowel Ischemia-Induced Lung Injury in Rats

To evaluate the effects of gut decontamination on endotoxin, tumor necrosis factor (TNF) levels, and the associated lung injury in a rat model of bowel ischemia. Summary background data:Gut ischemia induces disruption of the intestinal mucosal barrier, allowing translocation of bacteria and endotoxi...

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Veröffentlicht in:Chest 1997-08, Vol.112 (2), p.491-495
Hauptverfasser: Sorkine, Patrick, Szold, Oded, Halpern, Pinhas, Gutman, Mordechai, Greemland, Mazal, Rudick, Valery, Goldman, Gideon
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container_end_page 495
container_issue 2
container_start_page 491
container_title Chest
container_volume 112
creator Sorkine, Patrick
Szold, Oded
Halpern, Pinhas
Gutman, Mordechai
Greemland, Mazal
Rudick, Valery
Goldman, Gideon
description To evaluate the effects of gut decontamination on endotoxin, tumor necrosis factor (TNF) levels, and the associated lung injury in a rat model of bowel ischemia. Summary background data:Gut ischemia induces disruption of the intestinal mucosal barrier, allowing translocation of bacteria and endotoxin into the blood, which may trigger a systemic inflammatory response and lung injury. Thirty anesthetized rats were randomized into three groups: (1) ischemia-reperfusion (I/R) alone (a 60-min superior mesenteric artery occlusion and 4 h of reperfusion, n=10); (2) rats that underwent gut decontamination prior to ischemia (I/R+GD, n=10); and (3) control rats (sham operated, n=10). Serum levels of lipopolysaccharide (LPS) and TNF were measured at the end of the experiment. Lung permeability was measured using bovine serum albumin labeled with 125I, and organ injury was assessed histologically. One hour of bowel ischemia and 4 h of reperfusion (I/R) led to elevations of blood LPS and TNF levels of 0.33±0.005 EU/mL and 173±56 pg/mL, which were higher than the sham group (p
doi_str_mv 10.1378/chest.112.2.491
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Summary background data:Gut ischemia induces disruption of the intestinal mucosal barrier, allowing translocation of bacteria and endotoxin into the blood, which may trigger a systemic inflammatory response and lung injury. Thirty anesthetized rats were randomized into three groups: (1) ischemia-reperfusion (I/R) alone (a 60-min superior mesenteric artery occlusion and 4 h of reperfusion, n=10); (2) rats that underwent gut decontamination prior to ischemia (I/R+GD, n=10); and (3) control rats (sham operated, n=10). Serum levels of lipopolysaccharide (LPS) and TNF were measured at the end of the experiment. Lung permeability was measured using bovine serum albumin labeled with 125I, and organ injury was assessed histologically. One hour of bowel ischemia and 4 h of reperfusion (I/R) led to elevations of blood LPS and TNF levels of 0.33±0.005 EU/mL and 173±56 pg/mL, which were higher than the sham group (p&lt;0.01). Gut decontamination (I/R+GD) significantly attenuated the LPS and TNF generation, 0.09±0.005 and 56.2±6 pg/mL (p&lt;0.01). Lung injury as assessed by pulmonary permeability index was also reduced by gut decontamination, 2.1 ±0.42 vs 5.3±0.82 in the control group (p&lt;0.03). Surprisingly no difference was detected in the number of pulmonary neutrophils in sequestration between the groups. Our data suggest that gut decontamination can reduce the generation of LPS, TNF, and the severity of lung damage that often follows ischemia and reperfusion of the intestine in rats.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.112.2.491</identifier><identifier>PMID: 9266889</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Bacterial Translocation ; Biological and medical sciences ; Blood-Air Barrier - physiology ; Cattle ; Drug Therapy, Combination - therapeutic use ; Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery ; endotoxemia ; Endotoxemia - prevention &amp; control ; Erythromycin - therapeutic use ; Granulocytes ; gut decontamination ; gut ischemia ; Intensive care medicine ; Intestines - blood supply ; Intestines - microbiology ; Iodine Radioisotopes ; Ischemia ; Laboratory animals ; Laparotomy ; Leukocytes ; lipopolysaccharide ; Lipopolysaccharides - blood ; lung injury ; Lungs ; Male ; Medical sciences ; Mesenteric Artery, Superior ; Mesenteric Vascular Occlusion - complications ; Neomycin - therapeutic use ; Neutrophils ; Permeability ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury - complications ; Respiratory Distress Syndrome, Adult - prevention &amp; control ; Serum Albumin, Bovine ; Time Factors ; tumor necrosis factor ; Tumor Necrosis Factor-alpha - analysis ; Tumor necrosis factor-TNF ; Veins &amp; arteries</subject><ispartof>Chest, 1997-08, Vol.112 (2), p.491-495</ispartof><rights>1997 The American College of Chest Physicians</rights><rights>1997 INIST-CNRS</rights><rights>Copyright American College of Chest Physicians Aug 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-1884bd588cb0b45cb9cdf5c2218991e1d24a19773093c77a0b968a3b541a66003</citedby><cites>FETCH-LOGICAL-c504t-1884bd588cb0b45cb9cdf5c2218991e1d24a19773093c77a0b968a3b541a66003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=2775321$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9266889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sorkine, Patrick</creatorcontrib><creatorcontrib>Szold, Oded</creatorcontrib><creatorcontrib>Halpern, Pinhas</creatorcontrib><creatorcontrib>Gutman, Mordechai</creatorcontrib><creatorcontrib>Greemland, Mazal</creatorcontrib><creatorcontrib>Rudick, Valery</creatorcontrib><creatorcontrib>Goldman, Gideon</creatorcontrib><title>Gut Decontamination Reduces Bowel Ischemia-Induced Lung Injury in Rats</title><title>Chest</title><addtitle>Chest</addtitle><description>To evaluate the effects of gut decontamination on endotoxin, tumor necrosis factor (TNF) levels, and the associated lung injury in a rat model of bowel ischemia. Summary background data:Gut ischemia induces disruption of the intestinal mucosal barrier, allowing translocation of bacteria and endotoxin into the blood, which may trigger a systemic inflammatory response and lung injury. Thirty anesthetized rats were randomized into three groups: (1) ischemia-reperfusion (I/R) alone (a 60-min superior mesenteric artery occlusion and 4 h of reperfusion, n=10); (2) rats that underwent gut decontamination prior to ischemia (I/R+GD, n=10); and (3) control rats (sham operated, n=10). Serum levels of lipopolysaccharide (LPS) and TNF were measured at the end of the experiment. Lung permeability was measured using bovine serum albumin labeled with 125I, and organ injury was assessed histologically. One hour of bowel ischemia and 4 h of reperfusion (I/R) led to elevations of blood LPS and TNF levels of 0.33±0.005 EU/mL and 173±56 pg/mL, which were higher than the sham group (p&lt;0.01). Gut decontamination (I/R+GD) significantly attenuated the LPS and TNF generation, 0.09±0.005 and 56.2±6 pg/mL (p&lt;0.01). Lung injury as assessed by pulmonary permeability index was also reduced by gut decontamination, 2.1 ±0.42 vs 5.3±0.82 in the control group (p&lt;0.03). Surprisingly no difference was detected in the number of pulmonary neutrophils in sequestration between the groups. Our data suggest that gut decontamination can reduce the generation of LPS, TNF, and the severity of lung damage that often follows ischemia and reperfusion of the intestine in rats.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Bacterial Translocation</subject><subject>Biological and medical sciences</subject><subject>Blood-Air Barrier - physiology</subject><subject>Cattle</subject><subject>Drug Therapy, Combination - therapeutic use</subject><subject>Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery</subject><subject>endotoxemia</subject><subject>Endotoxemia - prevention &amp; control</subject><subject>Erythromycin - therapeutic use</subject><subject>Granulocytes</subject><subject>gut decontamination</subject><subject>gut ischemia</subject><subject>Intensive care medicine</subject><subject>Intestines - blood supply</subject><subject>Intestines - microbiology</subject><subject>Iodine Radioisotopes</subject><subject>Ischemia</subject><subject>Laboratory animals</subject><subject>Laparotomy</subject><subject>Leukocytes</subject><subject>lipopolysaccharide</subject><subject>Lipopolysaccharides - blood</subject><subject>lung injury</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenteric Artery, Superior</subject><subject>Mesenteric Vascular Occlusion - complications</subject><subject>Neomycin - therapeutic use</subject><subject>Neutrophils</subject><subject>Permeability</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reperfusion Injury - complications</subject><subject>Respiratory Distress Syndrome, Adult - prevention &amp; control</subject><subject>Serum Albumin, Bovine</subject><subject>Time Factors</subject><subject>tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Tumor necrosis factor-TNF</subject><subject>Veins &amp; arteries</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kd1LwzAUxYMoc348-yQUEd-65SZpmzzq_BoMBNHnkKaZy2hTTVrF_97MFRHBp5Dc373n3BOETgBPgBZ8qlcmdBMAMiETJmAHjUFQSGnG6C4aYwwkpbkg--gghDWOdxD5CI0EyXPOxRjd3vVdcm106zrVWKc627rk0VS9NiG5aj9MncxDFGmsSudu81wli969JHO37v1nYiOtunCE9paqDuZ4OA_R8-3N0-w-XTzczWeXi1RnmHUpcM7KKuNcl7hkmS6FrpaZJgS4EGCgIkyBKAqKBdVFoXApcq5omTFQeY4xPUQX27mvvn3r4-qysUGbulbOtH2QhSAk52IDnv0B123vXfQmCcaMCkYgQtMtpH0bgjdL-epto_ynBCw38crveGWMVxIZ440dp8PYvmxM9cMPecb6-VBXQat66ZXTNvxgpCgy-lt4ZV9WH9YbGRpV13Eo3UoOZn8Li22Hiem-W-Nl0Na4-B2xW3eyau2_pr8AA5qluw</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Sorkine, Patrick</creator><creator>Szold, Oded</creator><creator>Halpern, Pinhas</creator><creator>Gutman, Mordechai</creator><creator>Greemland, Mazal</creator><creator>Rudick, Valery</creator><creator>Goldman, Gideon</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Gut Decontamination Reduces Bowel Ischemia-Induced Lung Injury in Rats</title><author>Sorkine, Patrick ; Szold, Oded ; Halpern, Pinhas ; Gutman, Mordechai ; Greemland, Mazal ; Rudick, Valery ; Goldman, Gideon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-1884bd588cb0b45cb9cdf5c2218991e1d24a19773093c77a0b968a3b541a66003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Bacterial Translocation</topic><topic>Biological and medical sciences</topic><topic>Blood-Air Barrier - physiology</topic><topic>Cattle</topic><topic>Drug Therapy, Combination - therapeutic use</topic><topic>Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery</topic><topic>endotoxemia</topic><topic>Endotoxemia - prevention &amp; control</topic><topic>Erythromycin - therapeutic use</topic><topic>Granulocytes</topic><topic>gut decontamination</topic><topic>gut ischemia</topic><topic>Intensive care medicine</topic><topic>Intestines - blood supply</topic><topic>Intestines - microbiology</topic><topic>Iodine Radioisotopes</topic><topic>Ischemia</topic><topic>Laboratory animals</topic><topic>Laparotomy</topic><topic>Leukocytes</topic><topic>lipopolysaccharide</topic><topic>Lipopolysaccharides - blood</topic><topic>lung injury</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesenteric Artery, Superior</topic><topic>Mesenteric Vascular Occlusion - complications</topic><topic>Neomycin - therapeutic use</topic><topic>Neutrophils</topic><topic>Permeability</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reperfusion Injury - complications</topic><topic>Respiratory Distress Syndrome, Adult - prevention &amp; control</topic><topic>Serum Albumin, Bovine</topic><topic>Time Factors</topic><topic>tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Tumor necrosis factor-TNF</topic><topic>Veins &amp; arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sorkine, Patrick</creatorcontrib><creatorcontrib>Szold, Oded</creatorcontrib><creatorcontrib>Halpern, Pinhas</creatorcontrib><creatorcontrib>Gutman, Mordechai</creatorcontrib><creatorcontrib>Greemland, Mazal</creatorcontrib><creatorcontrib>Rudick, Valery</creatorcontrib><creatorcontrib>Goldman, Gideon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sorkine, Patrick</au><au>Szold, Oded</au><au>Halpern, Pinhas</au><au>Gutman, Mordechai</au><au>Greemland, Mazal</au><au>Rudick, Valery</au><au>Goldman, Gideon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut Decontamination Reduces Bowel Ischemia-Induced Lung Injury in Rats</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>112</volume><issue>2</issue><spage>491</spage><epage>495</epage><pages>491-495</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>To evaluate the effects of gut decontamination on endotoxin, tumor necrosis factor (TNF) levels, and the associated lung injury in a rat model of bowel ischemia. Summary background data:Gut ischemia induces disruption of the intestinal mucosal barrier, allowing translocation of bacteria and endotoxin into the blood, which may trigger a systemic inflammatory response and lung injury. Thirty anesthetized rats were randomized into three groups: (1) ischemia-reperfusion (I/R) alone (a 60-min superior mesenteric artery occlusion and 4 h of reperfusion, n=10); (2) rats that underwent gut decontamination prior to ischemia (I/R+GD, n=10); and (3) control rats (sham operated, n=10). Serum levels of lipopolysaccharide (LPS) and TNF were measured at the end of the experiment. Lung permeability was measured using bovine serum albumin labeled with 125I, and organ injury was assessed histologically. One hour of bowel ischemia and 4 h of reperfusion (I/R) led to elevations of blood LPS and TNF levels of 0.33±0.005 EU/mL and 173±56 pg/mL, which were higher than the sham group (p&lt;0.01). Gut decontamination (I/R+GD) significantly attenuated the LPS and TNF generation, 0.09±0.005 and 56.2±6 pg/mL (p&lt;0.01). Lung injury as assessed by pulmonary permeability index was also reduced by gut decontamination, 2.1 ±0.42 vs 5.3±0.82 in the control group (p&lt;0.03). Surprisingly no difference was detected in the number of pulmonary neutrophils in sequestration between the groups. Our data suggest that gut decontamination can reduce the generation of LPS, TNF, and the severity of lung damage that often follows ischemia and reperfusion of the intestine in rats.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>9266889</pmid><doi>10.1378/chest.112.2.491</doi><tpages>5</tpages></addata></record>
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subjects Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Bacterial Translocation
Biological and medical sciences
Blood-Air Barrier - physiology
Cattle
Drug Therapy, Combination - therapeutic use
Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery
endotoxemia
Endotoxemia - prevention & control
Erythromycin - therapeutic use
Granulocytes
gut decontamination
gut ischemia
Intensive care medicine
Intestines - blood supply
Intestines - microbiology
Iodine Radioisotopes
Ischemia
Laboratory animals
Laparotomy
Leukocytes
lipopolysaccharide
Lipopolysaccharides - blood
lung injury
Lungs
Male
Medical sciences
Mesenteric Artery, Superior
Mesenteric Vascular Occlusion - complications
Neomycin - therapeutic use
Neutrophils
Permeability
Rats
Rats, Sprague-Dawley
Reperfusion Injury - complications
Respiratory Distress Syndrome, Adult - prevention & control
Serum Albumin, Bovine
Time Factors
tumor necrosis factor
Tumor Necrosis Factor-alpha - analysis
Tumor necrosis factor-TNF
Veins & arteries
title Gut Decontamination Reduces Bowel Ischemia-Induced Lung Injury in Rats
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