Gut Decontamination Reduces Bowel Ischemia-Induced Lung Injury in Rats
To evaluate the effects of gut decontamination on endotoxin, tumor necrosis factor (TNF) levels, and the associated lung injury in a rat model of bowel ischemia. Summary background data:Gut ischemia induces disruption of the intestinal mucosal barrier, allowing translocation of bacteria and endotoxi...
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Veröffentlicht in: | Chest 1997-08, Vol.112 (2), p.491-495 |
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creator | Sorkine, Patrick Szold, Oded Halpern, Pinhas Gutman, Mordechai Greemland, Mazal Rudick, Valery Goldman, Gideon |
description | To evaluate the effects of gut decontamination on endotoxin, tumor necrosis factor (TNF) levels, and the associated lung injury in a rat model of bowel ischemia.
Summary background data:Gut ischemia induces disruption of the intestinal mucosal barrier, allowing translocation of bacteria and endotoxin into the blood, which may trigger a systemic inflammatory response and lung injury.
Thirty anesthetized rats were randomized into three groups: (1) ischemia-reperfusion (I/R) alone (a 60-min superior mesenteric artery occlusion and 4 h of reperfusion, n=10); (2) rats that underwent gut decontamination prior to ischemia (I/R+GD, n=10); and (3) control rats (sham operated, n=10). Serum levels of lipopolysaccharide (LPS) and TNF were measured at the end of the experiment. Lung permeability was measured using bovine serum albumin labeled with 125I, and organ injury was assessed histologically.
One hour of bowel ischemia and 4 h of reperfusion (I/R) led to elevations of blood LPS and TNF levels of 0.33±0.005 EU/mL and 173±56 pg/mL, which were higher than the sham group (p |
doi_str_mv | 10.1378/chest.112.2.491 |
format | Article |
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Summary background data:Gut ischemia induces disruption of the intestinal mucosal barrier, allowing translocation of bacteria and endotoxin into the blood, which may trigger a systemic inflammatory response and lung injury.
Thirty anesthetized rats were randomized into three groups: (1) ischemia-reperfusion (I/R) alone (a 60-min superior mesenteric artery occlusion and 4 h of reperfusion, n=10); (2) rats that underwent gut decontamination prior to ischemia (I/R+GD, n=10); and (3) control rats (sham operated, n=10). Serum levels of lipopolysaccharide (LPS) and TNF were measured at the end of the experiment. Lung permeability was measured using bovine serum albumin labeled with 125I, and organ injury was assessed histologically.
One hour of bowel ischemia and 4 h of reperfusion (I/R) led to elevations of blood LPS and TNF levels of 0.33±0.005 EU/mL and 173±56 pg/mL, which were higher than the sham group (p<0.01). Gut decontamination (I/R+GD) significantly attenuated the LPS and TNF generation, 0.09±0.005 and 56.2±6 pg/mL (p<0.01). Lung injury as assessed by pulmonary permeability index was also reduced by gut decontamination, 2.1 ±0.42 vs 5.3±0.82 in the control group (p<0.03). Surprisingly no difference was detected in the number of pulmonary neutrophils in sequestration between the groups.
Our data suggest that gut decontamination can reduce the generation of LPS, TNF, and the severity of lung damage that often follows ischemia and reperfusion of the intestine in rats.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.112.2.491</identifier><identifier>PMID: 9266889</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Bacterial Translocation ; Biological and medical sciences ; Blood-Air Barrier - physiology ; Cattle ; Drug Therapy, Combination - therapeutic use ; Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery ; endotoxemia ; Endotoxemia - prevention & control ; Erythromycin - therapeutic use ; Granulocytes ; gut decontamination ; gut ischemia ; Intensive care medicine ; Intestines - blood supply ; Intestines - microbiology ; Iodine Radioisotopes ; Ischemia ; Laboratory animals ; Laparotomy ; Leukocytes ; lipopolysaccharide ; Lipopolysaccharides - blood ; lung injury ; Lungs ; Male ; Medical sciences ; Mesenteric Artery, Superior ; Mesenteric Vascular Occlusion - complications ; Neomycin - therapeutic use ; Neutrophils ; Permeability ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury - complications ; Respiratory Distress Syndrome, Adult - prevention & control ; Serum Albumin, Bovine ; Time Factors ; tumor necrosis factor ; Tumor Necrosis Factor-alpha - analysis ; Tumor necrosis factor-TNF ; Veins & arteries</subject><ispartof>Chest, 1997-08, Vol.112 (2), p.491-495</ispartof><rights>1997 The American College of Chest Physicians</rights><rights>1997 INIST-CNRS</rights><rights>Copyright American College of Chest Physicians Aug 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-1884bd588cb0b45cb9cdf5c2218991e1d24a19773093c77a0b968a3b541a66003</citedby><cites>FETCH-LOGICAL-c504t-1884bd588cb0b45cb9cdf5c2218991e1d24a19773093c77a0b968a3b541a66003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2775321$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9266889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sorkine, Patrick</creatorcontrib><creatorcontrib>Szold, Oded</creatorcontrib><creatorcontrib>Halpern, Pinhas</creatorcontrib><creatorcontrib>Gutman, Mordechai</creatorcontrib><creatorcontrib>Greemland, Mazal</creatorcontrib><creatorcontrib>Rudick, Valery</creatorcontrib><creatorcontrib>Goldman, Gideon</creatorcontrib><title>Gut Decontamination Reduces Bowel Ischemia-Induced Lung Injury in Rats</title><title>Chest</title><addtitle>Chest</addtitle><description>To evaluate the effects of gut decontamination on endotoxin, tumor necrosis factor (TNF) levels, and the associated lung injury in a rat model of bowel ischemia.
Summary background data:Gut ischemia induces disruption of the intestinal mucosal barrier, allowing translocation of bacteria and endotoxin into the blood, which may trigger a systemic inflammatory response and lung injury.
Thirty anesthetized rats were randomized into three groups: (1) ischemia-reperfusion (I/R) alone (a 60-min superior mesenteric artery occlusion and 4 h of reperfusion, n=10); (2) rats that underwent gut decontamination prior to ischemia (I/R+GD, n=10); and (3) control rats (sham operated, n=10). Serum levels of lipopolysaccharide (LPS) and TNF were measured at the end of the experiment. Lung permeability was measured using bovine serum albumin labeled with 125I, and organ injury was assessed histologically.
One hour of bowel ischemia and 4 h of reperfusion (I/R) led to elevations of blood LPS and TNF levels of 0.33±0.005 EU/mL and 173±56 pg/mL, which were higher than the sham group (p<0.01). Gut decontamination (I/R+GD) significantly attenuated the LPS and TNF generation, 0.09±0.005 and 56.2±6 pg/mL (p<0.01). Lung injury as assessed by pulmonary permeability index was also reduced by gut decontamination, 2.1 ±0.42 vs 5.3±0.82 in the control group (p<0.03). Surprisingly no difference was detected in the number of pulmonary neutrophils in sequestration between the groups.
Our data suggest that gut decontamination can reduce the generation of LPS, TNF, and the severity of lung damage that often follows ischemia and reperfusion of the intestine in rats.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Bacterial Translocation</subject><subject>Biological and medical sciences</subject><subject>Blood-Air Barrier - physiology</subject><subject>Cattle</subject><subject>Drug Therapy, Combination - therapeutic use</subject><subject>Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery</subject><subject>endotoxemia</subject><subject>Endotoxemia - prevention & control</subject><subject>Erythromycin - therapeutic use</subject><subject>Granulocytes</subject><subject>gut decontamination</subject><subject>gut ischemia</subject><subject>Intensive care medicine</subject><subject>Intestines - blood supply</subject><subject>Intestines - microbiology</subject><subject>Iodine Radioisotopes</subject><subject>Ischemia</subject><subject>Laboratory animals</subject><subject>Laparotomy</subject><subject>Leukocytes</subject><subject>lipopolysaccharide</subject><subject>Lipopolysaccharides - blood</subject><subject>lung injury</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenteric Artery, Superior</subject><subject>Mesenteric Vascular Occlusion - complications</subject><subject>Neomycin - therapeutic use</subject><subject>Neutrophils</subject><subject>Permeability</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reperfusion Injury - complications</subject><subject>Respiratory Distress Syndrome, Adult - prevention & control</subject><subject>Serum Albumin, Bovine</subject><subject>Time Factors</subject><subject>tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Tumor necrosis factor-TNF</subject><subject>Veins & arteries</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kd1LwzAUxYMoc348-yQUEd-65SZpmzzq_BoMBNHnkKaZy2hTTVrF_97MFRHBp5Dc373n3BOETgBPgBZ8qlcmdBMAMiETJmAHjUFQSGnG6C4aYwwkpbkg--gghDWOdxD5CI0EyXPOxRjd3vVdcm106zrVWKc627rk0VS9NiG5aj9MncxDFGmsSudu81wli969JHO37v1nYiOtunCE9paqDuZ4OA_R8-3N0-w-XTzczWeXi1RnmHUpcM7KKuNcl7hkmS6FrpaZJgS4EGCgIkyBKAqKBdVFoXApcq5omTFQeY4xPUQX27mvvn3r4-qysUGbulbOtH2QhSAk52IDnv0B123vXfQmCcaMCkYgQtMtpH0bgjdL-epto_ynBCw38crveGWMVxIZ440dp8PYvmxM9cMPecb6-VBXQat66ZXTNvxgpCgy-lt4ZV9WH9YbGRpV13Eo3UoOZn8Li22Hiem-W-Nl0Na4-B2xW3eyau2_pr8AA5qluw</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Sorkine, Patrick</creator><creator>Szold, Oded</creator><creator>Halpern, Pinhas</creator><creator>Gutman, Mordechai</creator><creator>Greemland, Mazal</creator><creator>Rudick, Valery</creator><creator>Goldman, Gideon</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Gut Decontamination Reduces Bowel Ischemia-Induced Lung Injury in Rats</title><author>Sorkine, Patrick ; Szold, Oded ; Halpern, Pinhas ; Gutman, Mordechai ; Greemland, Mazal ; Rudick, Valery ; Goldman, Gideon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-1884bd588cb0b45cb9cdf5c2218991e1d24a19773093c77a0b968a3b541a66003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Bacterial Translocation</topic><topic>Biological and medical sciences</topic><topic>Blood-Air Barrier - physiology</topic><topic>Cattle</topic><topic>Drug Therapy, Combination - therapeutic use</topic><topic>Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery</topic><topic>endotoxemia</topic><topic>Endotoxemia - prevention & control</topic><topic>Erythromycin - therapeutic use</topic><topic>Granulocytes</topic><topic>gut decontamination</topic><topic>gut ischemia</topic><topic>Intensive care medicine</topic><topic>Intestines - blood supply</topic><topic>Intestines - microbiology</topic><topic>Iodine Radioisotopes</topic><topic>Ischemia</topic><topic>Laboratory animals</topic><topic>Laparotomy</topic><topic>Leukocytes</topic><topic>lipopolysaccharide</topic><topic>Lipopolysaccharides - blood</topic><topic>lung injury</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesenteric Artery, Superior</topic><topic>Mesenteric Vascular Occlusion - complications</topic><topic>Neomycin - therapeutic use</topic><topic>Neutrophils</topic><topic>Permeability</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reperfusion Injury - complications</topic><topic>Respiratory Distress Syndrome, Adult - prevention & control</topic><topic>Serum Albumin, Bovine</topic><topic>Time Factors</topic><topic>tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Tumor necrosis factor-TNF</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sorkine, Patrick</creatorcontrib><creatorcontrib>Szold, Oded</creatorcontrib><creatorcontrib>Halpern, Pinhas</creatorcontrib><creatorcontrib>Gutman, Mordechai</creatorcontrib><creatorcontrib>Greemland, Mazal</creatorcontrib><creatorcontrib>Rudick, Valery</creatorcontrib><creatorcontrib>Goldman, Gideon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sorkine, Patrick</au><au>Szold, Oded</au><au>Halpern, Pinhas</au><au>Gutman, Mordechai</au><au>Greemland, Mazal</au><au>Rudick, Valery</au><au>Goldman, Gideon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut Decontamination Reduces Bowel Ischemia-Induced Lung Injury in Rats</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>112</volume><issue>2</issue><spage>491</spage><epage>495</epage><pages>491-495</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>To evaluate the effects of gut decontamination on endotoxin, tumor necrosis factor (TNF) levels, and the associated lung injury in a rat model of bowel ischemia.
Summary background data:Gut ischemia induces disruption of the intestinal mucosal barrier, allowing translocation of bacteria and endotoxin into the blood, which may trigger a systemic inflammatory response and lung injury.
Thirty anesthetized rats were randomized into three groups: (1) ischemia-reperfusion (I/R) alone (a 60-min superior mesenteric artery occlusion and 4 h of reperfusion, n=10); (2) rats that underwent gut decontamination prior to ischemia (I/R+GD, n=10); and (3) control rats (sham operated, n=10). Serum levels of lipopolysaccharide (LPS) and TNF were measured at the end of the experiment. Lung permeability was measured using bovine serum albumin labeled with 125I, and organ injury was assessed histologically.
One hour of bowel ischemia and 4 h of reperfusion (I/R) led to elevations of blood LPS and TNF levels of 0.33±0.005 EU/mL and 173±56 pg/mL, which were higher than the sham group (p<0.01). Gut decontamination (I/R+GD) significantly attenuated the LPS and TNF generation, 0.09±0.005 and 56.2±6 pg/mL (p<0.01). Lung injury as assessed by pulmonary permeability index was also reduced by gut decontamination, 2.1 ±0.42 vs 5.3±0.82 in the control group (p<0.03). Surprisingly no difference was detected in the number of pulmonary neutrophils in sequestration between the groups.
Our data suggest that gut decontamination can reduce the generation of LPS, TNF, and the severity of lung damage that often follows ischemia and reperfusion of the intestine in rats.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>9266889</pmid><doi>10.1378/chest.112.2.491</doi><tpages>5</tpages></addata></record> |
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subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Bacterial Translocation Biological and medical sciences Blood-Air Barrier - physiology Cattle Drug Therapy, Combination - therapeutic use Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery endotoxemia Endotoxemia - prevention & control Erythromycin - therapeutic use Granulocytes gut decontamination gut ischemia Intensive care medicine Intestines - blood supply Intestines - microbiology Iodine Radioisotopes Ischemia Laboratory animals Laparotomy Leukocytes lipopolysaccharide Lipopolysaccharides - blood lung injury Lungs Male Medical sciences Mesenteric Artery, Superior Mesenteric Vascular Occlusion - complications Neomycin - therapeutic use Neutrophils Permeability Rats Rats, Sprague-Dawley Reperfusion Injury - complications Respiratory Distress Syndrome, Adult - prevention & control Serum Albumin, Bovine Time Factors tumor necrosis factor Tumor Necrosis Factor-alpha - analysis Tumor necrosis factor-TNF Veins & arteries |
title | Gut Decontamination Reduces Bowel Ischemia-Induced Lung Injury in Rats |
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