Development of Tolerance in Mice to the Sedative Effects of the Neuroactive Steroid Minaxolone Following Chronic Exposure

Minaxolone is a potent ligand for the neurosteroid binding site of the GABA A receptor. In radioligand binding studies to rat brain membranes, minaxolone caused a 69% increase in [ 3H]muscimol binding and a 25% increase in [ 3H]flunitrazepam binding and inhibited the binding of [ 3H]TBOB with an IC...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1997-09, Vol.58 (1), p.1-8
Hauptverfasser:	Marshall, Fiona H, Stratton, Sharon C, Mullings, Joanne, Ford, Elaine, Worton, Stella P, Oakley, Nigel R, Hagan, Russell M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics - pharmacology Animals Biological and medical sciences Dose-Response Relationship, Drug Drug Tolerance Flunitrazepam - metabolism Flunitrazepam - pharmacology GABA GABA A receptor GABA Agonists - metabolism GABA Modulators - metabolism GABA Modulators - pharmacology GABA-A Receptor Antagonists Hypnotics and Sedatives - pharmacology Hypnotics. Sedatives In Vitro Techniques Locomotor activity Mice Male Medical sciences Membranes - metabolism Mice Mice, Inbred Strains Minaxolone Motor Activity - drug effects Muscimol - metabolism Neuropharmacology Neurosteroid Pharmacology. Drug treatments Pregnanolone - analogs & derivatives Pregnanolone - pharmacology Psychology. Psychoanalysis. Psychiatry Psychopharmacology Radioligand Assay Rats Temazepam Temazepam - metabolism Temazepam - pharmacology Tolerance
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