Moxonidine inhibits Na+/H+ exchange in proximal tubule cells and cortical collecting duct

Moxonidine inhibits Na+/H+ exchange in proximal tubule cells and cortical collecting duct. The imidazoline receptor agonist moxonidine has been recently introduced as an antihypertensive therapy. Imidazoline specific binding sites have also been found in the kidney. Moxonidine induced natriuresis an...

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Veröffentlicht in:	Kidney international 1997-08, Vol.52 (2), p.454-459
Hauptverfasser:	Schlatter, Eberhard, Ankorina-Stark, Ieva, Haxelmans, Sabine, Hohage, Helge
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - pharmacology Animals Antihypertensive agents Antihypertensive Agents - pharmacology antihypertensive drugs Biological and medical sciences blood pressure control Cardiovascular system Female Fluoresceins Fluorescent Dyes Guanidines - pharmacology Hydrogen-Ion Concentration hypertension Idazoxan - pharmacology Imidazoles - pharmacology imidazoline-receptor agonist Kidney Tubules, Collecting - chemistry Kidney Tubules, Collecting - drug effects Kidney Tubules, Proximal - chemistry Kidney Tubules, Proximal - drug effects LLC-PK1 Cells Medical sciences moxonidine Na+/H+ exchange Pharmacology. Drug treatments Rats Rats, Wistar Sodium-Hydrogen Exchangers - antagonists & inhibitors Sulfones - pharmacology Swine Yohimbine - pharmacology
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