Increased affinity of type II corticosteroid binding in aged rat hippocampus

Hippocampal tissue from young-mature (3–4 months old) and aged (24–26 months old) Fischer-344 rats was assessed for type I and type II corticosteroid binding in cytosol, using [ 3H]dexamethasone and selective inhibition of type II sites with nonradioactive RU-28362. Twenty-four hours after adrenalec...

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Veröffentlicht in:	Experimental neurology 1989-10, Vol.106 (1), p.110-113
Hauptverfasser:	Landfield, Philip W., Eldridge, J.Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Adrenals. Interrenals Aging - metabolism Androstanols - pharmacology Animals Biological and medical sciences Dexamethasone - metabolism Fundamental and applied biological sciences. Psychology Hippocampus - metabolism Male Morphology. Functional localizations Rats Rats, Inbred F344 Receptors, Glucocorticoid - drug effects Receptors, Glucocorticoid - metabolism Vertebrates: endocrinology
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