Fuzzy logic for model adaptation of a pharmacokinetic-based closed loop delivery system for pancuronium
In this paper, we investigate the ability of fuzzy logic to adapt the parameters of a pharmacokinetic and pharmacodynamic model-based controller for the delivery of the muscle relaxant pancuronium. The system uses the model to control the rate of drug delivery and uses feedback from a sensor which m...
Gespeichert in:
| Veröffentlicht in: | Artificial intelligence in medicine 1997-09, Vol.11 (1), p.9-31 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 31 |
|---|---|
| container_issue | 1 |
| container_start_page | 9 |
| container_title | Artificial intelligence in medicine |
| container_volume | 11 |
| creator | Kern, Steven E Johnson, Joel O Westenskow, Dwayne R |
| description | In this paper, we investigate the ability of fuzzy logic to adapt the parameters of a pharmacokinetic and pharmacodynamic model-based controller for the delivery of the muscle relaxant pancuronium. The system uses the model to control the rate of drug delivery and uses feedback from a sensor which measures muscle relaxation level to adapt the model using fuzzy logic. The control strategy administers mini-bolus doses of pancuronium and modulates the magnitude and time interval between the bolus doses to maintain a patient's muscle relaxation within an allowable range specified by the user. Before each new dose is given, the fuzzy logic adaptation scheme uses the error between the predicted patient response and the measured response to adapt the model. The system was tested using computer simulation by varying the parameters of the model by 50% from their nominal values. It was also evaluated in a clinical trial of five patients undergoing surgical procedures lasting 5 h or longer. |
| doi_str_mv | 10.1016/S0933-3657(97)00022-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79225786</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0933365797000225</els_id><sourcerecordid>79225786</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-6b9d473555acd082de1018f515250157352ba9f36b1cad77a19bebe0b695cceb3</originalsourceid><addsrcrecordid>eNqFkUlvFDEQhS0UFIbAT4jkEwqHDl7G2wmhUUIiRcoBOFteqoOhu93Y3ZEmv56eRbnOqQ7ve_VU9RC6pOSaEiq__CCG84ZLoa6M-kwIYawRb9CKasUbpiU5Q6tX5B16X-ufBVJrKs_RuWFSCW1W6Ol2fnnZ4i4_pYDbXHCfI3TYRTdObkp5wLnFDo-_XeldyH_TAFMKjXcVIg5d3o0u5xEvrvQMZYvrtk7Q73eNbghzyUOa-w_obeu6Ch-P8wL9ur35ublrHh6_32--PTRhLfjUSG_iWnEhhAuRaBZhuVW3ggomCBWLwrwzLZeeBheVctR48EC8NCIE8PwCfTrsHUv-N0OdbJ9qgK5zA-S5WmUYE0rLk6BYPkU0oSdBJoVmmp4GqaSMcLOLFgcwlFxrgdaOJfWubC0ldtet3Xdrd8VZo-y-WysW3-UxYPY9xFfXscxF_3rQYXnwc4Jia0gwBIipQJhszOlEwn9HHbRz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16120396</pqid></control><display><type>article</type><title>Fuzzy logic for model adaptation of a pharmacokinetic-based closed loop delivery system for pancuronium</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kern, Steven E ; Johnson, Joel O ; Westenskow, Dwayne R</creator><creatorcontrib>Kern, Steven E ; Johnson, Joel O ; Westenskow, Dwayne R</creatorcontrib><description>In this paper, we investigate the ability of fuzzy logic to adapt the parameters of a pharmacokinetic and pharmacodynamic model-based controller for the delivery of the muscle relaxant pancuronium. The system uses the model to control the rate of drug delivery and uses feedback from a sensor which measures muscle relaxation level to adapt the model using fuzzy logic. The control strategy administers mini-bolus doses of pancuronium and modulates the magnitude and time interval between the bolus doses to maintain a patient's muscle relaxation within an allowable range specified by the user. Before each new dose is given, the fuzzy logic adaptation scheme uses the error between the predicted patient response and the measured response to adapt the model. The system was tested using computer simulation by varying the parameters of the model by 50% from their nominal values. It was also evaluated in a clinical trial of five patients undergoing surgical procedures lasting 5 h or longer.</description><identifier>ISSN: 0933-3657</identifier><identifier>EISSN: 1873-2860</identifier><identifier>DOI: 10.1016/S0933-3657(97)00022-5</identifier><identifier>PMID: 9267589</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adaptive closed loop control ; Adult ; Aged ; Anesthesia ; Computer applications ; Computer Simulation ; Drug Delivery Systems ; Female ; Fuzzy Logic ; Fuzzy set theory ; Humans ; Male ; Middle Aged ; Models, Biological ; Muscle relaxants ; Muscle Relaxation - drug effects ; Neuromuscular Nondepolarizing Agents - administration & dosage ; Neuromuscular Nondepolarizing Agents - pharmacokinetics ; Neuromuscular Nondepolarizing Agents - pharmacology ; Pancuronium - administration & dosage ; Pancuronium - pharmacokinetics ; Pancuronium - pharmacology ; Pharmaceutics ; Pharmacodynamic ; Pharmacokinetic</subject><ispartof>Artificial intelligence in medicine, 1997-09, Vol.11 (1), p.9-31</ispartof><rights>1997 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-6b9d473555acd082de1018f515250157352ba9f36b1cad77a19bebe0b695cceb3</citedby><cites>FETCH-LOGICAL-c453t-6b9d473555acd082de1018f515250157352ba9f36b1cad77a19bebe0b695cceb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0933365797000225$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9267589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kern, Steven E</creatorcontrib><creatorcontrib>Johnson, Joel O</creatorcontrib><creatorcontrib>Westenskow, Dwayne R</creatorcontrib><title>Fuzzy logic for model adaptation of a pharmacokinetic-based closed loop delivery system for pancuronium</title><title>Artificial intelligence in medicine</title><addtitle>Artif Intell Med</addtitle><description>In this paper, we investigate the ability of fuzzy logic to adapt the parameters of a pharmacokinetic and pharmacodynamic model-based controller for the delivery of the muscle relaxant pancuronium. The system uses the model to control the rate of drug delivery and uses feedback from a sensor which measures muscle relaxation level to adapt the model using fuzzy logic. The control strategy administers mini-bolus doses of pancuronium and modulates the magnitude and time interval between the bolus doses to maintain a patient's muscle relaxation within an allowable range specified by the user. Before each new dose is given, the fuzzy logic adaptation scheme uses the error between the predicted patient response and the measured response to adapt the model. The system was tested using computer simulation by varying the parameters of the model by 50% from their nominal values. It was also evaluated in a clinical trial of five patients undergoing surgical procedures lasting 5 h or longer.</description><subject>Adaptive closed loop control</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Computer applications</subject><subject>Computer Simulation</subject><subject>Drug Delivery Systems</subject><subject>Female</subject><subject>Fuzzy Logic</subject><subject>Fuzzy set theory</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Muscle relaxants</subject><subject>Muscle Relaxation - drug effects</subject><subject>Neuromuscular Nondepolarizing Agents - administration & dosage</subject><subject>Neuromuscular Nondepolarizing Agents - pharmacokinetics</subject><subject>Neuromuscular Nondepolarizing Agents - pharmacology</subject><subject>Pancuronium - administration & dosage</subject><subject>Pancuronium - pharmacokinetics</subject><subject>Pancuronium - pharmacology</subject><subject>Pharmaceutics</subject><subject>Pharmacodynamic</subject><subject>Pharmacokinetic</subject><issn>0933-3657</issn><issn>1873-2860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUlvFDEQhS0UFIbAT4jkEwqHDl7G2wmhUUIiRcoBOFteqoOhu93Y3ZEmv56eRbnOqQ7ve_VU9RC6pOSaEiq__CCG84ZLoa6M-kwIYawRb9CKasUbpiU5Q6tX5B16X-ufBVJrKs_RuWFSCW1W6Ol2fnnZ4i4_pYDbXHCfI3TYRTdObkp5wLnFDo-_XeldyH_TAFMKjXcVIg5d3o0u5xEvrvQMZYvrtk7Q73eNbghzyUOa-w_obeu6Ch-P8wL9ur35ublrHh6_32--PTRhLfjUSG_iWnEhhAuRaBZhuVW3ggomCBWLwrwzLZeeBheVctR48EC8NCIE8PwCfTrsHUv-N0OdbJ9qgK5zA-S5WmUYE0rLk6BYPkU0oSdBJoVmmp4GqaSMcLOLFgcwlFxrgdaOJfWubC0ldtet3Xdrd8VZo-y-WysW3-UxYPY9xFfXscxF_3rQYXnwc4Jia0gwBIipQJhszOlEwn9HHbRz</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Kern, Steven E</creator><creator>Johnson, Joel O</creator><creator>Westenskow, Dwayne R</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SC</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>E3H</scope><scope>F2A</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>Fuzzy logic for model adaptation of a pharmacokinetic-based closed loop delivery system for pancuronium</title><author>Kern, Steven E ; Johnson, Joel O ; Westenskow, Dwayne R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-6b9d473555acd082de1018f515250157352ba9f36b1cad77a19bebe0b695cceb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adaptive closed loop control</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia</topic><topic>Computer applications</topic><topic>Computer Simulation</topic><topic>Drug Delivery Systems</topic><topic>Female</topic><topic>Fuzzy Logic</topic><topic>Fuzzy set theory</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Muscle relaxants</topic><topic>Muscle Relaxation - drug effects</topic><topic>Neuromuscular Nondepolarizing Agents - administration & dosage</topic><topic>Neuromuscular Nondepolarizing Agents - pharmacokinetics</topic><topic>Neuromuscular Nondepolarizing Agents - pharmacology</topic><topic>Pancuronium - administration & dosage</topic><topic>Pancuronium - pharmacokinetics</topic><topic>Pancuronium - pharmacology</topic><topic>Pharmaceutics</topic><topic>Pharmacodynamic</topic><topic>Pharmacokinetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kern, Steven E</creatorcontrib><creatorcontrib>Johnson, Joel O</creatorcontrib><creatorcontrib>Westenskow, Dwayne R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Library & Information Sciences Abstracts (LISA)</collection><collection>Library & Information Science Abstracts (LISA)</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial intelligence in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kern, Steven E</au><au>Johnson, Joel O</au><au>Westenskow, Dwayne R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fuzzy logic for model adaptation of a pharmacokinetic-based closed loop delivery system for pancuronium</atitle><jtitle>Artificial intelligence in medicine</jtitle><addtitle>Artif Intell Med</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>11</volume><issue>1</issue><spage>9</spage><epage>31</epage><pages>9-31</pages><issn>0933-3657</issn><eissn>1873-2860</eissn><abstract>In this paper, we investigate the ability of fuzzy logic to adapt the parameters of a pharmacokinetic and pharmacodynamic model-based controller for the delivery of the muscle relaxant pancuronium. The system uses the model to control the rate of drug delivery and uses feedback from a sensor which measures muscle relaxation level to adapt the model using fuzzy logic. The control strategy administers mini-bolus doses of pancuronium and modulates the magnitude and time interval between the bolus doses to maintain a patient's muscle relaxation within an allowable range specified by the user. Before each new dose is given, the fuzzy logic adaptation scheme uses the error between the predicted patient response and the measured response to adapt the model. The system was tested using computer simulation by varying the parameters of the model by 50% from their nominal values. It was also evaluated in a clinical trial of five patients undergoing surgical procedures lasting 5 h or longer.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9267589</pmid><doi>10.1016/S0933-3657(97)00022-5</doi><tpages>23</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0933-3657 |
| ispartof | Artificial intelligence in medicine, 1997-09, Vol.11 (1), p.9-31 |
| issn | 0933-3657 1873-2860 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79225786 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adaptive closed loop control Adult Aged Anesthesia Computer applications Computer Simulation Drug Delivery Systems Female Fuzzy Logic Fuzzy set theory Humans Male Middle Aged Models, Biological Muscle relaxants Muscle Relaxation - drug effects Neuromuscular Nondepolarizing Agents - administration & dosage Neuromuscular Nondepolarizing Agents - pharmacokinetics Neuromuscular Nondepolarizing Agents - pharmacology Pancuronium - administration & dosage Pancuronium - pharmacokinetics Pancuronium - pharmacology Pharmaceutics Pharmacodynamic Pharmacokinetic |
| title | Fuzzy logic for model adaptation of a pharmacokinetic-based closed loop delivery system for pancuronium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T09%3A12%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fuzzy%20logic%20for%20model%20adaptation%20of%20a%20pharmacokinetic-based%20closed%20loop%20delivery%20system%20for%20pancuronium&rft.jtitle=Artificial%20intelligence%20in%20medicine&rft.au=Kern,%20Steven%20E&rft.date=1997-09-01&rft.volume=11&rft.issue=1&rft.spage=9&rft.epage=31&rft.pages=9-31&rft.issn=0933-3657&rft.eissn=1873-2860&rft_id=info:doi/10.1016/S0933-3657(97)00022-5&rft_dat=%3Cproquest_cross%3E79225786%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16120396&rft_id=info:pmid/9267589&rft_els_id=S0933365797000225&rfr_iscdi=true |