Histopathological Appraisal of Carbon-dioxide Laser Dorsal Root Entry Zone (DREZ) Lesions in Primates
Dorsal Root Entry Zone (DREZ) thermocoagulation using radiofrequency has sucessfully been employed in the treatment of various deafferentation pain syndromes. The ability of surgical lasers to produce discrete lesions with precision has prompted their use in DREZ lesioning. The effects of carbon-dio...
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| Veröffentlicht in: | British journal of neurosurgery 1989, Vol.3 (3), p.373-379 |
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| creator | Singh, Jetinder P. Chandy, Mathew J. Joseph, Thomas Chandi, Sushil M. |
| description | Dorsal Root Entry Zone (DREZ) thermocoagulation using radiofrequency has sucessfully been employed in the treatment of various deafferentation pain syndromes. The ability of surgical lasers to produce discrete lesions with precision has prompted their use in DREZ lesioning. The effects of carbon-dioxide laser induced DREZ lesions in the primate spinal cord were studied in the Bonnet monkey and the parameters necessary to produce a histologically ideal DREZ lesion were evaluated. Lesions were made with 10, 15 and 20 Watts power for pulse durations of 100 to 400 milliseconds at a constant beam spot size of 0.4 mm. It was found that histologically ideal lesions were produced with 20 Watts of power and a pulse duration of 300 milliseconds and with 15 Watts power and 400 millisecond pulse duration. The lesion lengths and widths at different parameters were also comparativly evaluated. The postulated mechanisms of deafferentation pain and the possible mode of action of DREZ lesions in management of pain are also reviewed. |
| doi_str_mv | 10.3109/02688698909002818 |
| format | Article |
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The ability of surgical lasers to produce discrete lesions with precision has prompted their use in DREZ lesioning. The effects of carbon-dioxide laser induced DREZ lesions in the primate spinal cord were studied in the Bonnet monkey and the parameters necessary to produce a histologically ideal DREZ lesion were evaluated. Lesions were made with 10, 15 and 20 Watts power for pulse durations of 100 to 400 milliseconds at a constant beam spot size of 0.4 mm. It was found that histologically ideal lesions were produced with 20 Watts of power and a pulse duration of 300 milliseconds and with 15 Watts power and 400 millisecond pulse duration. The lesion lengths and widths at different parameters were also comparativly evaluated. The postulated mechanisms of deafferentation pain and the possible mode of action of DREZ lesions in management of pain are also reviewed.</description><identifier>ISSN: 0268-8697</identifier><identifier>EISSN: 1360-046X</identifier><identifier>DOI: 10.3109/02688698909002818</identifier><identifier>PMID: 2477029</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; carbon-dioxide laser ; Deafferentation pain ; Dorsal Root Entry Zone lesions ; Ganglia, Spinal - pathology ; Ganglia, Spinal - surgery ; Light Coagulation ; Macaca radiata ; Pain, Intractable - surgery ; Palliative Care - methods</subject><ispartof>British journal of neurosurgery, 1989, Vol.3 (3), p.373-379</ispartof><rights>1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-98205052d27d3383287f794049a75d718b938c9b369166ccd66e51f28a70ec5e3</citedby><cites>FETCH-LOGICAL-c316t-98205052d27d3383287f794049a75d718b938c9b369166ccd66e51f28a70ec5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02688698909002818$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02688698909002818$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4022,27921,27922,27923,59645,59751,60434,60540,61219,61254,61400,61435</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2477029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Jetinder P.</creatorcontrib><creatorcontrib>Chandy, Mathew J.</creatorcontrib><creatorcontrib>Joseph, Thomas</creatorcontrib><creatorcontrib>Chandi, Sushil M.</creatorcontrib><title>Histopathological Appraisal of Carbon-dioxide Laser Dorsal Root Entry Zone (DREZ) Lesions in Primates</title><title>British journal of neurosurgery</title><addtitle>Br J Neurosurg</addtitle><description>Dorsal Root Entry Zone (DREZ) thermocoagulation using radiofrequency has sucessfully been employed in the treatment of various deafferentation pain syndromes. The ability of surgical lasers to produce discrete lesions with precision has prompted their use in DREZ lesioning. The effects of carbon-dioxide laser induced DREZ lesions in the primate spinal cord were studied in the Bonnet monkey and the parameters necessary to produce a histologically ideal DREZ lesion were evaluated. Lesions were made with 10, 15 and 20 Watts power for pulse durations of 100 to 400 milliseconds at a constant beam spot size of 0.4 mm. It was found that histologically ideal lesions were produced with 20 Watts of power and a pulse duration of 300 milliseconds and with 15 Watts power and 400 millisecond pulse duration. The lesion lengths and widths at different parameters were also comparativly evaluated. The postulated mechanisms of deafferentation pain and the possible mode of action of DREZ lesions in management of pain are also reviewed.</description><subject>Animals</subject><subject>carbon-dioxide laser</subject><subject>Deafferentation pain</subject><subject>Dorsal Root Entry Zone lesions</subject><subject>Ganglia, Spinal - pathology</subject><subject>Ganglia, Spinal - surgery</subject><subject>Light Coagulation</subject><subject>Macaca radiata</subject><subject>Pain, Intractable - surgery</subject><subject>Palliative Care - methods</subject><issn>0268-8697</issn><issn>1360-046X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1rE0EUxQdRaqz-AT4I8yT1YXU-svOBvpQ0tYWAUhSkL8tk9q6Zspm7zkyw-e-7S4IgYp_uhXPOj8Mh5DVn7yVn9gMTyhhljWWWMWG4eUJmXCpWsbn68ZTMJr0aDfo5eZHzHWNc1EyfkBMx15oJOyNwFXLBwZUN9vgzeNfT82FILuTxw44uXFpjrNqA96EFunIZEr3ANMk3iIUuY0l7eosR6NnFzfL2HV1BDhgzDZF-TWHrCuSX5Fnn-gyvjveUfL9cfltcVasvn68X56vKS65KZY1gNatFK3QrpZHC6E7bOZtbp-tWc7O20ni7lspypbxvlYKad8I4zcDXIE_J2wN3SPhrB7k025A99L2LgLvcaCtELRUfjfxg9AlzTtA1w1Q17RvOmmna5p9px8ybI3y33kL7J3HcctQ_HfQQO0xb9xtT3zbF7XtMXXLRhzyh_4__-Fd8A64vG-8SNHe4S3Hc7ZFyDxbbl_k</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Singh, Jetinder P.</creator><creator>Chandy, Mathew J.</creator><creator>Joseph, Thomas</creator><creator>Chandi, Sushil M.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Histopathological Appraisal of Carbon-dioxide Laser Dorsal Root Entry Zone (DREZ) Lesions in Primates</title><author>Singh, Jetinder P. ; Chandy, Mathew J. ; Joseph, Thomas ; Chandi, Sushil M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-98205052d27d3383287f794049a75d718b938c9b369166ccd66e51f28a70ec5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>carbon-dioxide laser</topic><topic>Deafferentation pain</topic><topic>Dorsal Root Entry Zone lesions</topic><topic>Ganglia, Spinal - pathology</topic><topic>Ganglia, Spinal - surgery</topic><topic>Light Coagulation</topic><topic>Macaca radiata</topic><topic>Pain, Intractable - surgery</topic><topic>Palliative Care - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Jetinder P.</creatorcontrib><creatorcontrib>Chandy, Mathew J.</creatorcontrib><creatorcontrib>Joseph, Thomas</creatorcontrib><creatorcontrib>Chandi, Sushil M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Jetinder P.</au><au>Chandy, Mathew J.</au><au>Joseph, Thomas</au><au>Chandi, Sushil M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathological Appraisal of Carbon-dioxide Laser Dorsal Root Entry Zone (DREZ) Lesions in Primates</atitle><jtitle>British journal of neurosurgery</jtitle><addtitle>Br J Neurosurg</addtitle><date>1989</date><risdate>1989</risdate><volume>3</volume><issue>3</issue><spage>373</spage><epage>379</epage><pages>373-379</pages><issn>0268-8697</issn><eissn>1360-046X</eissn><abstract>Dorsal Root Entry Zone (DREZ) thermocoagulation using radiofrequency has sucessfully been employed in the treatment of various deafferentation pain syndromes. The ability of surgical lasers to produce discrete lesions with precision has prompted their use in DREZ lesioning. The effects of carbon-dioxide laser induced DREZ lesions in the primate spinal cord were studied in the Bonnet monkey and the parameters necessary to produce a histologically ideal DREZ lesion were evaluated. Lesions were made with 10, 15 and 20 Watts power for pulse durations of 100 to 400 milliseconds at a constant beam spot size of 0.4 mm. It was found that histologically ideal lesions were produced with 20 Watts of power and a pulse duration of 300 milliseconds and with 15 Watts power and 400 millisecond pulse duration. The lesion lengths and widths at different parameters were also comparativly evaluated. The postulated mechanisms of deafferentation pain and the possible mode of action of DREZ lesions in management of pain are also reviewed.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>2477029</pmid><doi>10.3109/02688698909002818</doi><tpages>7</tpages></addata></record> |
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| ispartof | British journal of neurosurgery, 1989, Vol.3 (3), p.373-379 |
| issn | 0268-8697 1360-046X |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals carbon-dioxide laser Deafferentation pain Dorsal Root Entry Zone lesions Ganglia, Spinal - pathology Ganglia, Spinal - surgery Light Coagulation Macaca radiata Pain, Intractable - surgery Palliative Care - methods |
| title | Histopathological Appraisal of Carbon-dioxide Laser Dorsal Root Entry Zone (DREZ) Lesions in Primates |
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