Appearance of predictors of disease progression in relation to the development of AIDS
To study the natural history of HIV-1 infection in relation to serological and immunological profiles, 199 asymptomatic HIV-1-antibody (HIV-1-core-antibody)-seropositive and 76 seroconverted homosexual men were followed prospectively for 39 months. AIDS was diagnosed in 38 men. The AIDS attack rate...
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| Veröffentlicht in: | AIDS (London) 1989-09, Vol.3 (9), p.563-569 |
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| creator | de Wolf, F Lange, J M Houweling, J T Mulder, J W Beemster, J Schellekens, P T Coutinho, R A van der Noordaa, J Goudsmit, J |
| description | To study the natural history of HIV-1 infection in relation to serological and immunological profiles, 199 asymptomatic HIV-1-antibody (HIV-1-core-antibody)-seropositive and 76 seroconverted homosexual men were followed prospectively for 39 months. AIDS was diagnosed in 38 men. The AIDS attack rate was 20.8% after 39 months. The AIDS attack rate in the HIV-I-core-antibody positives was 12.1, versus 30.1% in the HIV-1-core-antibody negatives (P less than 0.001), and it was 13.3% in the HIV-1-antigen (HIV-1-Ag) negatives versus 53.9% in the HIV-1-Ag positives (P less than 0.001). The AIDS attack rate after 39 months was 10.9% in men with counts greater than or equal to 0.5 x 10(9)/l and 49.9% in those with CD4+ lymphocyte counts less than 0.5 x 10(9)/l. AIDS attack rates after 30 months in the same cohort have been previously reported [1], and were as follows: 6.8% in the core-antibody positives versus 35.7% in the core-antibody negatives. 6.9% in the HIV-1-Ag negatives versus 43.9% in the HIV-1-Ag positives, and 6.1% in those with CD4+ lymphocyte counts greater than or equal to 0.5 versus 51.9% in those with CD4+ lymphocyte counts less than 0.5 x 10(9)/l. The disappearance of core antibody, the appearance of antigen and the occurrence of low CD4+ lymphocyte counts preceded AIDS by a mean (s.d.) of 21.3 (8.9), 17.7 (8.8) and 15.7 (8.9) months, respectively. |
| doi_str_mv | 10.1097/00002030-198909000-00002 |
| format | Article |
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AIDS was diagnosed in 38 men. The AIDS attack rate was 20.8% after 39 months. The AIDS attack rate in the HIV-I-core-antibody positives was 12.1, versus 30.1% in the HIV-1-core-antibody negatives (P less than 0.001), and it was 13.3% in the HIV-1-antigen (HIV-1-Ag) negatives versus 53.9% in the HIV-1-Ag positives (P less than 0.001). The AIDS attack rate after 39 months was 10.9% in men with counts greater than or equal to 0.5 x 10(9)/l and 49.9% in those with CD4+ lymphocyte counts less than 0.5 x 10(9)/l. AIDS attack rates after 30 months in the same cohort have been previously reported [1], and were as follows: 6.8% in the core-antibody positives versus 35.7% in the core-antibody negatives. 6.9% in the HIV-1-Ag negatives versus 43.9% in the HIV-1-Ag positives, and 6.1% in those with CD4+ lymphocyte counts greater than or equal to 0.5 versus 51.9% in those with CD4+ lymphocyte counts less than 0.5 x 10(9)/l. The disappearance of core antibody, the appearance of antigen and the occurrence of low CD4+ lymphocyte counts preceded AIDS by a mean (s.d.) of 21.3 (8.9), 17.7 (8.8) and 15.7 (8.9) months, respectively.</description><identifier>ISSN: 0269-9370</identifier><identifier>DOI: 10.1097/00002030-198909000-00002</identifier><identifier>PMID: 2571348</identifier><language>eng</language><publisher>England</publisher><subject>Acquired Immunodeficiency Syndrome - blood ; Acquired Immunodeficiency Syndrome - classification ; Acquired Immunodeficiency Syndrome - immunology ; Acquired Immunodeficiency Syndrome - physiopathology ; Adult ; AIDS/HIV ; CD4-Positive T-Lymphocytes - analysis ; CD4-Positive T-Lymphocytes - immunology ; Chi-Square Distribution ; Cohort Studies ; HIV Antibodies - analysis ; HIV Antibodies - immunology ; HIV Antigens - analysis ; HIV Antigens - immunology ; HIV Infections - blood ; HIV Infections - immunology ; HIV Infections - physiopathology ; HIV Seropositivity - blood ; HIV Seropositivity - immunology ; HIV Seropositivity - physiopathology ; HIV-1 - immunology ; Homosexuality ; Humans ; Incidence ; Life Tables ; Male ; Netherlands ; Prevalence ; Prospective Studies ; Risk Factors ; T-Lymphocytes, Regulatory - analysis ; T-Lymphocytes, Regulatory - immunology ; Time Factors ; Viral Core Proteins - immunology</subject><ispartof>AIDS (London), 1989-09, Vol.3 (9), p.563-569</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-173734cfbf93bad360d248151c2d77563074d25e5c8d08ff7736b1acd3a6cbeb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2571348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Wolf, F</creatorcontrib><creatorcontrib>Lange, J M</creatorcontrib><creatorcontrib>Houweling, J T</creatorcontrib><creatorcontrib>Mulder, J W</creatorcontrib><creatorcontrib>Beemster, J</creatorcontrib><creatorcontrib>Schellekens, P T</creatorcontrib><creatorcontrib>Coutinho, R A</creatorcontrib><creatorcontrib>van der Noordaa, J</creatorcontrib><creatorcontrib>Goudsmit, J</creatorcontrib><title>Appearance of predictors of disease progression in relation to the development of AIDS</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>To study the natural history of HIV-1 infection in relation to serological and immunological profiles, 199 asymptomatic HIV-1-antibody (HIV-1-core-antibody)-seropositive and 76 seroconverted homosexual men were followed prospectively for 39 months. AIDS was diagnosed in 38 men. The AIDS attack rate was 20.8% after 39 months. The AIDS attack rate in the HIV-I-core-antibody positives was 12.1, versus 30.1% in the HIV-1-core-antibody negatives (P less than 0.001), and it was 13.3% in the HIV-1-antigen (HIV-1-Ag) negatives versus 53.9% in the HIV-1-Ag positives (P less than 0.001). The AIDS attack rate after 39 months was 10.9% in men with counts greater than or equal to 0.5 x 10(9)/l and 49.9% in those with CD4+ lymphocyte counts less than 0.5 x 10(9)/l. AIDS attack rates after 30 months in the same cohort have been previously reported [1], and were as follows: 6.8% in the core-antibody positives versus 35.7% in the core-antibody negatives. 6.9% in the HIV-1-Ag negatives versus 43.9% in the HIV-1-Ag positives, and 6.1% in those with CD4+ lymphocyte counts greater than or equal to 0.5 versus 51.9% in those with CD4+ lymphocyte counts less than 0.5 x 10(9)/l. The disappearance of core antibody, the appearance of antigen and the occurrence of low CD4+ lymphocyte counts preceded AIDS by a mean (s.d.) of 21.3 (8.9), 17.7 (8.8) and 15.7 (8.9) months, respectively.</description><subject>Acquired Immunodeficiency Syndrome - blood</subject><subject>Acquired Immunodeficiency Syndrome - classification</subject><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Acquired Immunodeficiency Syndrome - physiopathology</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>CD4-Positive T-Lymphocytes - analysis</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Chi-Square Distribution</subject><subject>Cohort Studies</subject><subject>HIV Antibodies - analysis</subject><subject>HIV Antibodies - immunology</subject><subject>HIV Antigens - analysis</subject><subject>HIV Antigens - immunology</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - physiopathology</subject><subject>HIV Seropositivity - blood</subject><subject>HIV Seropositivity - immunology</subject><subject>HIV Seropositivity - physiopathology</subject><subject>HIV-1 - immunology</subject><subject>Homosexuality</subject><subject>Humans</subject><subject>Incidence</subject><subject>Life Tables</subject><subject>Male</subject><subject>Netherlands</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>T-Lymphocytes, Regulatory - analysis</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Time Factors</subject><subject>Viral Core Proteins - immunology</subject><issn>0269-9370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUMtOwzAQ9AFUSuETkHLiFvArsX2syqtSJQ48rpFjbyAoiYPtIvH3OLT0yl52dzQzuxqEMoKvCFbiGqeimOGcKKmwSlv-Cx2hOaalyhUT-ASdhvCR0AJLOUMzWgjCuJyj1-U4gvZ6MJC5Jhs92NZE58O02TaADpBQ9-YhhNYNWTtkHjodpzm6LL5DZuELOjf2MMRJtVzfPJ2h40Z3Ac73fYFe7m6fVw_55vF-vVpucsM4iTkRTDBumrpRrNaWldhSLklBDLVCFCXDgltaQGGkxbJphGBlTbSxTJemhpot0OXON734uYUQq74NBrpOD-C2oRKKUs6T0X9EUrBSCKwSUe6IxrsQPDTV6Nte---K4GrKu_rLuzrkvYOS9GJ_Y1v3YA_CfdjsB9x_fQo</recordid><startdate>19890901</startdate><enddate>19890901</enddate><creator>de Wolf, F</creator><creator>Lange, J M</creator><creator>Houweling, J T</creator><creator>Mulder, J W</creator><creator>Beemster, J</creator><creator>Schellekens, P T</creator><creator>Coutinho, R A</creator><creator>van der Noordaa, J</creator><creator>Goudsmit, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19890901</creationdate><title>Appearance of predictors of disease progression in relation to the development of AIDS</title><author>de Wolf, F ; Lange, J M ; Houweling, J T ; Mulder, J W ; Beemster, J ; Schellekens, P T ; Coutinho, R A ; van der Noordaa, J ; Goudsmit, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-173734cfbf93bad360d248151c2d77563074d25e5c8d08ff7736b1acd3a6cbeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acquired Immunodeficiency Syndrome - blood</topic><topic>Acquired Immunodeficiency Syndrome - classification</topic><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>Acquired Immunodeficiency Syndrome - physiopathology</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>CD4-Positive T-Lymphocytes - analysis</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Chi-Square Distribution</topic><topic>Cohort Studies</topic><topic>HIV Antibodies - analysis</topic><topic>HIV Antibodies - immunology</topic><topic>HIV Antigens - analysis</topic><topic>HIV Antigens - immunology</topic><topic>HIV Infections - blood</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - physiopathology</topic><topic>HIV Seropositivity - blood</topic><topic>HIV Seropositivity - immunology</topic><topic>HIV Seropositivity - physiopathology</topic><topic>HIV-1 - immunology</topic><topic>Homosexuality</topic><topic>Humans</topic><topic>Incidence</topic><topic>Life Tables</topic><topic>Male</topic><topic>Netherlands</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>T-Lymphocytes, Regulatory - analysis</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Time Factors</topic><topic>Viral Core Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Wolf, F</creatorcontrib><creatorcontrib>Lange, J M</creatorcontrib><creatorcontrib>Houweling, J T</creatorcontrib><creatorcontrib>Mulder, J W</creatorcontrib><creatorcontrib>Beemster, J</creatorcontrib><creatorcontrib>Schellekens, P T</creatorcontrib><creatorcontrib>Coutinho, R A</creatorcontrib><creatorcontrib>van der Noordaa, J</creatorcontrib><creatorcontrib>Goudsmit, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Wolf, F</au><au>Lange, J M</au><au>Houweling, J T</au><au>Mulder, J W</au><au>Beemster, J</au><au>Schellekens, P T</au><au>Coutinho, R A</au><au>van der Noordaa, J</au><au>Goudsmit, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Appearance of predictors of disease progression in relation to the development of AIDS</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>1989-09-01</date><risdate>1989</risdate><volume>3</volume><issue>9</issue><spage>563</spage><epage>569</epage><pages>563-569</pages><issn>0269-9370</issn><abstract>To study the natural history of HIV-1 infection in relation to serological and immunological profiles, 199 asymptomatic HIV-1-antibody (HIV-1-core-antibody)-seropositive and 76 seroconverted homosexual men were followed prospectively for 39 months. AIDS was diagnosed in 38 men. The AIDS attack rate was 20.8% after 39 months. The AIDS attack rate in the HIV-I-core-antibody positives was 12.1, versus 30.1% in the HIV-1-core-antibody negatives (P less than 0.001), and it was 13.3% in the HIV-1-antigen (HIV-1-Ag) negatives versus 53.9% in the HIV-1-Ag positives (P less than 0.001). The AIDS attack rate after 39 months was 10.9% in men with counts greater than or equal to 0.5 x 10(9)/l and 49.9% in those with CD4+ lymphocyte counts less than 0.5 x 10(9)/l. AIDS attack rates after 30 months in the same cohort have been previously reported [1], and were as follows: 6.8% in the core-antibody positives versus 35.7% in the core-antibody negatives. 6.9% in the HIV-1-Ag negatives versus 43.9% in the HIV-1-Ag positives, and 6.1% in those with CD4+ lymphocyte counts greater than or equal to 0.5 versus 51.9% in those with CD4+ lymphocyte counts less than 0.5 x 10(9)/l. The disappearance of core antibody, the appearance of antigen and the occurrence of low CD4+ lymphocyte counts preceded AIDS by a mean (s.d.) of 21.3 (8.9), 17.7 (8.8) and 15.7 (8.9) months, respectively.</abstract><cop>England</cop><pmid>2571348</pmid><doi>10.1097/00002030-198909000-00002</doi><tpages>7</tpages></addata></record> |
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| ispartof | AIDS (London), 1989-09, Vol.3 (9), p.563-569 |
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| subjects | Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - classification Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - physiopathology Adult AIDS/HIV CD4-Positive T-Lymphocytes - analysis CD4-Positive T-Lymphocytes - immunology Chi-Square Distribution Cohort Studies HIV Antibodies - analysis HIV Antibodies - immunology HIV Antigens - analysis HIV Antigens - immunology HIV Infections - blood HIV Infections - immunology HIV Infections - physiopathology HIV Seropositivity - blood HIV Seropositivity - immunology HIV Seropositivity - physiopathology HIV-1 - immunology Homosexuality Humans Incidence Life Tables Male Netherlands Prevalence Prospective Studies Risk Factors T-Lymphocytes, Regulatory - analysis T-Lymphocytes, Regulatory - immunology Time Factors Viral Core Proteins - immunology |
| title | Appearance of predictors of disease progression in relation to the development of AIDS |
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