Use of survivorsʼ cardiorespiratory values as therapeutic goals in septic shock
The responses to therapy of 29 patients in septic shock are described. Patients received controlled plasma volume expansion followed by infusions of norepinephrine, dobutamine, and dopamine to achieve appropriate therapeutic goals. Increases in oxygen delivery (DO2) from 605 ± 40 (SEM) to 843 ± 27 m...
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| Veröffentlicht in: | Critical care medicine 1989-11, Vol.17 (11), p.1098-1103 |
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| container_title | Critical care medicine |
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| creator | EDWARDS, J DENIS S. BROWN, G CERI NIGHTINGALE, PETER SLATER, ROGER M FARAGHER, E BRIAN |
| description | The responses to therapy of 29 patients in septic shock are described. Patients received controlled plasma volume expansion followed by infusions of norepinephrine, dobutamine, and dopamine to achieve appropriate therapeutic goals. Increases in oxygen delivery (DO2) from 605 ± 40 (SEM) to 843 ± 27 ml/min ± m (p < .001) were associated with increases in oxygen consumption (DO2) from 130 ± 6.8 to 169 ± 6.2 ml/min-m (p < .001). The overall hospital survival rate was 52%. We suggest that the rational use of adrenergic agents and the achievement of appropriate physiologic end-points for therapy not only result in the reversal of hypotension, but also maintain or increase DO2 and DO2, and may improve survival. |
| doi_str_mv | 10.1097/00003246-198911000-00002 |
| format | Article |
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We suggest that the rational use of adrenergic agents and the achievement of appropriate physiologic end-points for therapy not only result in the reversal of hypotension, but also maintain or increase DO2 and DO2, and may improve survival.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-198911000-00002</identifier><identifier>PMID: 2791588</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. 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BROWN, G CERI</creatorcontrib><creatorcontrib>NIGHTINGALE, PETER</creatorcontrib><creatorcontrib>SLATER, ROGER M</creatorcontrib><creatorcontrib>FARAGHER, E BRIAN</creatorcontrib><title>Use of survivorsʼ cardiorespiratory values as therapeutic goals in septic shock</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>The responses to therapy of 29 patients in septic shock are described. Patients received controlled plasma volume expansion followed by infusions of norepinephrine, dobutamine, and dopamine to achieve appropriate therapeutic goals. Increases in oxygen delivery (DO2) from 605 ± 40 (SEM) to 843 ± 27 ml/min ± m (p < .001) were associated with increases in oxygen consumption (DO2) from 130 ± 6.8 to 169 ± 6.2 ml/min-m (p < .001). The overall hospital survival rate was 52%. We suggest that the rational use of adrenergic agents and the achievement of appropriate physiologic end-points for therapy not only result in the reversal of hypotension, but also maintain or increase DO2 and DO2, and may improve survival.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Critical Care - methods</subject><subject>Dobutamine - therapeutic use</subject><subject>Dopamine - therapeutic use</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Female</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Norepinephrine - therapeutic use</subject><subject>Oxygen Consumption</subject><subject>Plasma Substitutes - therapeutic use</subject><subject>Prospective Studies</subject><subject>Shock, Septic - mortality</subject><subject>Shock, Septic - therapy</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UctuFDEQtFBQsgQ-IZIvyW3AbtuxfYwiAkiR4EDOltfTww6ZXU_cMxvl3_gCvgovuwkn3AerqqsfLjPGpXgvhbcfRD0K9GUjvfNSVtTsKHjFFtKoCsCrI7YQwotGaa9O2Buin0JIbaw6ZsdgvTTOLdi3O0KeO05z2fbbXOj3L55iaftckMa-xCmXJ76Nw4zEI_FphSWOOE994j9yHIj3G0447jCtcrp_y153lcZ3h_uU3d18_H79ubn9-unL9dVtk5Qz0Jgkoe18DYEWltpDdM62S3Ctbi14FzVcCmmE9bE-cQmms2hd12pwaKNUp-xi33cs-aEuN4V1TwmHIW4wzxSsBwAjXBW6vTCVTFSwC2Pp17E8BSnCzszwbGZ4MfMvBbX07DBjXq6xfSk8uFfz54d8pBSHrsRN6ulff6-ltdpUnd7rHvMwYaH7YX7EElYYh2kV_veX6g_6BIy2</recordid><startdate>198911</startdate><enddate>198911</enddate><creator>EDWARDS, J DENIS</creator><creator>S. 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Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Critical Care - methods</topic><topic>Dobutamine - therapeutic use</topic><topic>Dopamine - therapeutic use</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Female</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Norepinephrine - therapeutic use</topic><topic>Oxygen Consumption</topic><topic>Plasma Substitutes - therapeutic use</topic><topic>Prospective Studies</topic><topic>Shock, Septic - mortality</topic><topic>Shock, Septic - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EDWARDS, J DENIS</creatorcontrib><creatorcontrib>S. 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BROWN, G CERI</au><au>NIGHTINGALE, PETER</au><au>SLATER, ROGER M</au><au>FARAGHER, E BRIAN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of survivorsʼ cardiorespiratory values as therapeutic goals in septic shock</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1989-11</date><risdate>1989</risdate><volume>17</volume><issue>11</issue><spage>1098</spage><epage>1103</epage><pages>1098-1103</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>The responses to therapy of 29 patients in septic shock are described. Patients received controlled plasma volume expansion followed by infusions of norepinephrine, dobutamine, and dopamine to achieve appropriate therapeutic goals. Increases in oxygen delivery (DO2) from 605 ± 40 (SEM) to 843 ± 27 ml/min ± m (p < .001) were associated with increases in oxygen consumption (DO2) from 130 ± 6.8 to 169 ± 6.2 ml/min-m (p < .001). The overall hospital survival rate was 52%. We suggest that the rational use of adrenergic agents and the achievement of appropriate physiologic end-points for therapy not only result in the reversal of hypotension, but also maintain or increase DO2 and DO2, and may improve survival.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>2791588</pmid><doi>10.1097/00003246-198911000-00002</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-3493 |
| ispartof | Critical care medicine, 1989-11, Vol.17 (11), p.1098-1103 |
| issn | 0090-3493 1530-0293 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Critical Care - methods Dobutamine - therapeutic use Dopamine - therapeutic use Emergency and intensive care: infection, septic shock Female Hemodynamics - drug effects Humans Intensive care medicine Male Medical sciences Middle Aged Norepinephrine - therapeutic use Oxygen Consumption Plasma Substitutes - therapeutic use Prospective Studies Shock, Septic - mortality Shock, Septic - therapy |
| title | Use of survivorsʼ cardiorespiratory values as therapeutic goals in septic shock |
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