Vomiting after strabismus surgery in children : ondansetron vs propofol
To compare the antiemetic efficacy and costs associated with two anaesthetic regimens in children undergoing strabismus surgery. One regimen contained halothane, nitrous oxide and ondansetron, while the other contained propofol and nitrous oxide. Three hundred children aged 2-14 yr undergoing strabi...
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Veröffentlicht in: | Canadian journal of anesthesia 1997-08, Vol.44 (8), p.825-829 |
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description | To compare the antiemetic efficacy and costs associated with two anaesthetic regimens in children undergoing strabismus surgery. One regimen contained halothane, nitrous oxide and ondansetron, while the other contained propofol and nitrous oxide.
Three hundred children aged 2-14 yr undergoing strabismus surgery were enrolled into this single-blind, randomized, stratified, blocked study with a balanced design. Anaesthesia was induced by inhalation with halothane/N2O/O2 (Group O) or with 2.5-3.5 mg.kg-1 propofol + 0.5 mg.kg-1 lidocaine i.v. (Group P). Group O patients were administered 0.15 mg.kg-1 ondansetron (maximum dose 8 mg) i.v. and all patients received atropine 20 micrograms.kg-1 i.v. immediately after induction of anaesthesia. Anaesthesia was maintained with N2O and halothane (Group O) or N2O and propofol (Group P). Patients were followed for 24 hr after their operation primarily to assess the incidence of postoperative vomiting. For each case, the costs of the anaesthetic drugs administered and their associated intravenous administration tubing were determined. Drug costs were those prevailing at the study site at the time of the investigation. Fixed costs, such as the cost of the anaesthetic equipment were not assessed.
Groups were similar with respect to demographic data. The incidence of vomiting in both groups was 11% while in-hospital and 23% after discharge. Each episode of in-hospital vomiting prolonged discharge by 17 +/- 4 min, P < 0.001. Mean cost per case for anaesthetic drugs was less in Group O, 18 +/- 8 vs 21 +/- 10, CDN$, mean +/- SD, P < 0.01.
The two methods of antiemetic prophylaxis were equally effective. Propofol-based anaesthesia was more expensive. |
doi_str_mv | 10.1007/BF03013158 |
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Three hundred children aged 2-14 yr undergoing strabismus surgery were enrolled into this single-blind, randomized, stratified, blocked study with a balanced design. Anaesthesia was induced by inhalation with halothane/N2O/O2 (Group O) or with 2.5-3.5 mg.kg-1 propofol + 0.5 mg.kg-1 lidocaine i.v. (Group P). Group O patients were administered 0.15 mg.kg-1 ondansetron (maximum dose 8 mg) i.v. and all patients received atropine 20 micrograms.kg-1 i.v. immediately after induction of anaesthesia. Anaesthesia was maintained with N2O and halothane (Group O) or N2O and propofol (Group P). Patients were followed for 24 hr after their operation primarily to assess the incidence of postoperative vomiting. For each case, the costs of the anaesthetic drugs administered and their associated intravenous administration tubing were determined. Drug costs were those prevailing at the study site at the time of the investigation. Fixed costs, such as the cost of the anaesthetic equipment were not assessed.
Groups were similar with respect to demographic data. The incidence of vomiting in both groups was 11% while in-hospital and 23% after discharge. Each episode of in-hospital vomiting prolonged discharge by 17 +/- 4 min, P < 0.001. Mean cost per case for anaesthetic drugs was less in Group O, 18 +/- 8 vs 21 +/- 10, CDN$, mean +/- SD, P < 0.01.
The two methods of antiemetic prophylaxis were equally effective. Propofol-based anaesthesia was more expensive.</description><identifier>ISSN: 0832-610X</identifier><identifier>EISSN: 1496-8975</identifier><identifier>DOI: 10.1007/BF03013158</identifier><identifier>PMID: 9312453</identifier><identifier>CODEN: CJOAEP</identifier><language>eng</language><publisher>Toronto, ON: Canadian Anesthesiologists' Society</publisher><subject>Adolescent ; Antiemetics - therapeutic use ; Biological and medical sciences ; Child ; Child, Preschool ; Digestive system ; Female ; Health Care Costs ; Humans ; Male ; Medical sciences ; Ondansetron - therapeutic use ; Pharmacology. Drug treatments ; Postoperative Complications - prevention & control ; Propofol - therapeutic use ; Single-Blind Method ; Strabismus - surgery ; Vomiting - chemically induced ; Vomiting - prevention & control</subject><ispartof>Canadian journal of anesthesia, 1997-08, Vol.44 (8), p.825-829</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2801207$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9312453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SPLINTER, W. M</creatorcontrib><creatorcontrib>RHINE, E. J</creatorcontrib><creatorcontrib>ROBERTS, D. J</creatorcontrib><title>Vomiting after strabismus surgery in children : ondansetron vs propofol</title><title>Canadian journal of anesthesia</title><addtitle>Can J Anaesth</addtitle><description>To compare the antiemetic efficacy and costs associated with two anaesthetic regimens in children undergoing strabismus surgery. One regimen contained halothane, nitrous oxide and ondansetron, while the other contained propofol and nitrous oxide.
Three hundred children aged 2-14 yr undergoing strabismus surgery were enrolled into this single-blind, randomized, stratified, blocked study with a balanced design. Anaesthesia was induced by inhalation with halothane/N2O/O2 (Group O) or with 2.5-3.5 mg.kg-1 propofol + 0.5 mg.kg-1 lidocaine i.v. (Group P). Group O patients were administered 0.15 mg.kg-1 ondansetron (maximum dose 8 mg) i.v. and all patients received atropine 20 micrograms.kg-1 i.v. immediately after induction of anaesthesia. Anaesthesia was maintained with N2O and halothane (Group O) or N2O and propofol (Group P). Patients were followed for 24 hr after their operation primarily to assess the incidence of postoperative vomiting. For each case, the costs of the anaesthetic drugs administered and their associated intravenous administration tubing were determined. Drug costs were those prevailing at the study site at the time of the investigation. Fixed costs, such as the cost of the anaesthetic equipment were not assessed.
Groups were similar with respect to demographic data. The incidence of vomiting in both groups was 11% while in-hospital and 23% after discharge. Each episode of in-hospital vomiting prolonged discharge by 17 +/- 4 min, P < 0.001. Mean cost per case for anaesthetic drugs was less in Group O, 18 +/- 8 vs 21 +/- 10, CDN$, mean +/- SD, P < 0.01.
The two methods of antiemetic prophylaxis were equally effective. Propofol-based anaesthesia was more expensive.</description><subject>Adolescent</subject><subject>Antiemetics - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Digestive system</subject><subject>Female</subject><subject>Health Care Costs</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ondansetron - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Complications - prevention & control</subject><subject>Propofol - therapeutic use</subject><subject>Single-Blind Method</subject><subject>Strabismus - surgery</subject><subject>Vomiting - chemically induced</subject><subject>Vomiting - prevention & control</subject><issn>0832-610X</issn><issn>1496-8975</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j71LxDAAxYMo53m6uAsZxK2a7yZuengqHLiouJU0Tc5Im9SkFe6_t2BxesP78T4AOMfoGiNU3txvEEWYYi4PwBIzJQqpSn4IlkhSUgiMPo7BSc5fCCEpuFyAhaKYME6X4PE9dn7wYQe1G2yCeUi69rkbM8xj2tm0hz5A8-nbJtkAb2EMjQ7ZDikG-JNhn2IfXWxPwZHTbbZns67A2-bhdf1UbF8en9d326InlA9FiShtGFOYE90IZVltHHeYIOwYNUQ5USojORFNzZzQlmvrFMG2FtpIW0u6Ald_uVPx92jzUHU-G9u2Otg45qpUhGDJxARezOBYd7ap-uQ7nfbV_HzyL2dfZ6Nbl3QwPv9jRKJpVUl_Ac6ZZvo</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>SPLINTER, W. M</creator><creator>RHINE, E. J</creator><creator>ROBERTS, D. J</creator><general>Canadian Anesthesiologists' Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Vomiting after strabismus surgery in children : ondansetron vs propofol</title><author>SPLINTER, W. M ; RHINE, E. J ; ROBERTS, D. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-7033d449152ad69e4bcf5f1201f43c29f679c8526db4f6ae5aef921eb6ac8eb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Antiemetics - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Digestive system</topic><topic>Female</topic><topic>Health Care Costs</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ondansetron - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Complications - prevention & control</topic><topic>Propofol - therapeutic use</topic><topic>Single-Blind Method</topic><topic>Strabismus - surgery</topic><topic>Vomiting - chemically induced</topic><topic>Vomiting - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SPLINTER, W. M</creatorcontrib><creatorcontrib>RHINE, E. J</creatorcontrib><creatorcontrib>ROBERTS, D. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian journal of anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SPLINTER, W. M</au><au>RHINE, E. J</au><au>ROBERTS, D. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vomiting after strabismus surgery in children : ondansetron vs propofol</atitle><jtitle>Canadian journal of anesthesia</jtitle><addtitle>Can J Anaesth</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>44</volume><issue>8</issue><spage>825</spage><epage>829</epage><pages>825-829</pages><issn>0832-610X</issn><eissn>1496-8975</eissn><coden>CJOAEP</coden><abstract>To compare the antiemetic efficacy and costs associated with two anaesthetic regimens in children undergoing strabismus surgery. One regimen contained halothane, nitrous oxide and ondansetron, while the other contained propofol and nitrous oxide.
Three hundred children aged 2-14 yr undergoing strabismus surgery were enrolled into this single-blind, randomized, stratified, blocked study with a balanced design. Anaesthesia was induced by inhalation with halothane/N2O/O2 (Group O) or with 2.5-3.5 mg.kg-1 propofol + 0.5 mg.kg-1 lidocaine i.v. (Group P). Group O patients were administered 0.15 mg.kg-1 ondansetron (maximum dose 8 mg) i.v. and all patients received atropine 20 micrograms.kg-1 i.v. immediately after induction of anaesthesia. Anaesthesia was maintained with N2O and halothane (Group O) or N2O and propofol (Group P). Patients were followed for 24 hr after their operation primarily to assess the incidence of postoperative vomiting. For each case, the costs of the anaesthetic drugs administered and their associated intravenous administration tubing were determined. Drug costs were those prevailing at the study site at the time of the investigation. Fixed costs, such as the cost of the anaesthetic equipment were not assessed.
Groups were similar with respect to demographic data. The incidence of vomiting in both groups was 11% while in-hospital and 23% after discharge. Each episode of in-hospital vomiting prolonged discharge by 17 +/- 4 min, P < 0.001. Mean cost per case for anaesthetic drugs was less in Group O, 18 +/- 8 vs 21 +/- 10, CDN$, mean +/- SD, P < 0.01.
The two methods of antiemetic prophylaxis were equally effective. Propofol-based anaesthesia was more expensive.</abstract><cop>Toronto, ON</cop><pub>Canadian Anesthesiologists' Society</pub><pmid>9312453</pmid><doi>10.1007/BF03013158</doi><tpages>5</tpages></addata></record> |
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subjects | Adolescent Antiemetics - therapeutic use Biological and medical sciences Child Child, Preschool Digestive system Female Health Care Costs Humans Male Medical sciences Ondansetron - therapeutic use Pharmacology. Drug treatments Postoperative Complications - prevention & control Propofol - therapeutic use Single-Blind Method Strabismus - surgery Vomiting - chemically induced Vomiting - prevention & control |
title | Vomiting after strabismus surgery in children : ondansetron vs propofol |
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