DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA

Three groups of doxorubicin and daunorubicin analogues, differing by their substituents on the chromophore and sugar moieties, were used in this study. The 3'-N-unsubstituted (Group 1), 3'-N-acyl (Group 2), and 3'-N-alkyl (Group 3) analogues were tested for: (a) in vivo antitumor acti...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1989-11, Vol.49 (21), p.5969-5978
Hauptverfasser:	Bodley, A, Liu, L F, Israel, M, Seshadri, R, Koseki, Y, Giuliani, F C, Kirschenbaum, S, Silber, R, Potmesil, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - pharmacology Antibiotics, Antineoplastic - therapeutic use Cell Line Cell Survival - drug effects daunorubicin Daunorubicin - analogs & derivatives Daunorubicin - metabolism Daunorubicin - pharmacology Daunorubicin - therapeutic use DNA DNA Topoisomerases, Type II - metabolism DNA, Neoplasm - drug effects DNA, Neoplasm - metabolism doxorubicin Doxorubicin - analogs & derivatives Doxorubicin - metabolism Doxorubicin - pharmacology Doxorubicin - therapeutic use Humans Leukemia P388 - drug therapy Leukemia, Experimental Male Mice Mice, Inbred A Mice, Inbred DBA Mice, Inbred Strains Rats Rats, Inbred Strains Structure-Activity Relationship Tumor Cells, Cultured - cytology Tumor Cells, Cultured - drug effects Tumor Stem Cell Assay
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