Strand specificity of the topoisomerase II-mediated double-stranded DNA cleavage reaction

The strand specificity of topoisomerase II mediated DNA cleavage was analyzed at the nucleotide level by characterizing the enzyme's interaction with a strong DNA recognition site. This site was isolated from the promoter region of the extrachromosomal rRNA genes of Tetrahymena thermophila and...

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Veröffentlicht in:	Biochemistry (Easton) 1989-07, Vol.28 (15), p.6237-6244
Hauptverfasser:	Andersen, Anni H, Christiansen, Kent, Zechiedrich, E. Lynn, Jensen, Palle S, Osheroff, Neil, Westergaard, Ole
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Cell Nucleus - enzymology DNA DNA Topoisomerases, Type II - metabolism DNA, Ribosomal DNA, Single-Stranded Drosophila melanogaster - enzymology Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Isomerases Molecular Sequence Data Plasmids Restriction Mapping Substrate Specificity Tetrahymena
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