Antinociceptive effect of intrathecally administered antiserum against calcitonin gene-related peptide on thermal and mechanical noxious stimuli in experimental hyperalgesic rats

We compared the effects of intrathecal administration of antiserum against calcitonin gene-related peptide (CGRP) between thermo- and mechano-nociceptive responses, using experimental hyperalgesic rats. An intrathecal administration of anti-CGRP antiserum, but not antiserum absorbed by synthetic CGR...

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Veröffentlicht in:	Brain research 1989-09, Vol.497 (1), p.199-203
Hauptverfasser:	Kawamura, Minoru, Kuraishi, Yasushi, Minami, Masabumi, Satoh, Masamichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antinociception Antiserum Biological and medical sciences Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - immunology Calcitonin Gene-Related Peptide - physiology Fundamental and applied biological sciences. Psychology Hyperalgesia Hyperalgesia - metabolism Hyperesthesia - metabolism Immune Sera - pharmacology Injections, Spinal Intrathecal Male Noxious stimulus Pain - metabolism Rats Rats, Inbred Strains Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal cord Vertebrates: nervous system and sense organs
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