α-Latrotoxin Receptor, Latrophilin, Is a Novel Member of the Secretin Family of G Protein-coupled Receptors

α-Latrotoxin (LTX) stimulates massive exocytosis of synaptic vesicles and may help to elucidate the mechanism of regulation of neurosecretion. We have recently isolated latrophilin, the synaptic Ca2+-independent LTX receptor. Now we demonstrate that latrophilin is a novel member of the secretin fami...

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Veröffentlicht in:	The Journal of biological chemistry 1997-08, Vol.272 (34), p.21504-21508
Hauptverfasser:	Lelianova, Vera G., Davletov, Bazbek A., Sterling, Alistair, Rahman, M. Atiqur, Grishin, Eugene V., Totty, Nicholas F., Ushkaryov, Yuri A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Exocytosis GTP-Binding Proteins - physiology Membrane Glycoproteins - chemistry Molecular Sequence Data Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - metabolism Rats Receptors, Peptide - chemistry Receptors, Peptide - metabolism Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Spider Venoms - metabolism Synaptic Vesicles - metabolism
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