Effect of Supplemental Oral l-Arginine on Exercise Capacity in Patients With Stable Angina Pectoris
A randomized, double-blind, placebo-controlled study in patients with clinical symptoms of stable angina pectoris and healed myocardial infarction (n = 22) has shown that oral supplementation with L-arginine (6 g/day for 3 days) increases exercise capacity (tested on a Marquette case 12 treadmill ac...
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Veröffentlicht in: | The American journal of cardiology 1997-08, Vol.80 (3), p.331-333 |
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creator | Ceremużyński, Leszek Chamiec, Tomasz Herbaczyńska-Cedro, Krystyna |
description | A randomized, double-blind, placebo-controlled study in patients with clinical symptoms of stable angina pectoris and healed myocardial infarction (n = 22) has shown that oral supplementation with L-arginine (6 g/day for 3 days) increases exercise capacity (tested on a Marquette case 12 treadmill according to the modified Bruce protocol). Results suggest that the inefficient L-arginine/nitric oxide system contributes to limitation of myocardial perfusion and/or peripheral vasodilation during maximum exercise in patients with stable angina pectoris. |
doi_str_mv | 10.1016/S0002-9149(97)00354-8 |
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Results suggest that the inefficient L-arginine/nitric oxide system contributes to limitation of myocardial perfusion and/or peripheral vasodilation during maximum exercise in patients with stable angina pectoris.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(97)00354-8</identifier><identifier>PMID: 9264427</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Angina pectoris ; Angina Pectoris - physiopathology ; Arginine - pharmacology ; Biological and medical sciences ; Double-Blind Method ; Drug therapy ; Exercise ; Exercise Tolerance - drug effects ; Female ; General and cellular metabolism. Vitamins ; Humans ; Male ; Medical research ; Medical sciences ; Middle Aged ; Pharmacology. 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Results suggest that the inefficient L-arginine/nitric oxide system contributes to limitation of myocardial perfusion and/or peripheral vasodilation during maximum exercise in patients with stable angina pectoris.</description><subject>Adult</subject><subject>Aged</subject><subject>Angina pectoris</subject><subject>Angina Pectoris - physiopathology</subject><subject>Arginine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Drug therapy</subject><subject>Exercise</subject><subject>Exercise Tolerance - drug effects</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. 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Vitamins</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Vasodilation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ceremużyński, Leszek</creatorcontrib><creatorcontrib>Chamiec, Tomasz</creatorcontrib><creatorcontrib>Herbaczyńska-Cedro, Krystyna</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ceremużyński, Leszek</au><au>Chamiec, Tomasz</au><au>Herbaczyńska-Cedro, Krystyna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Supplemental Oral l-Arginine on Exercise Capacity in Patients With Stable Angina Pectoris</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>80</volume><issue>3</issue><spage>331</spage><epage>333</epage><pages>331-333</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>A randomized, double-blind, placebo-controlled study in patients with clinical symptoms of stable angina pectoris and healed myocardial infarction (n = 22) has shown that oral supplementation with L-arginine (6 g/day for 3 days) increases exercise capacity (tested on a Marquette case 12 treadmill according to the modified Bruce protocol). 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subjects | Adult Aged Angina pectoris Angina Pectoris - physiopathology Arginine - pharmacology Biological and medical sciences Double-Blind Method Drug therapy Exercise Exercise Tolerance - drug effects Female General and cellular metabolism. Vitamins Humans Male Medical research Medical sciences Middle Aged Pharmacology. Drug treatments Vasodilation - drug effects |
title | Effect of Supplemental Oral l-Arginine on Exercise Capacity in Patients With Stable Angina Pectoris |
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