Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease
Immunoblotting studies on mitochondria prepared from the striata of patients who died of Parkinson's disease were performed using specific antisera against Complexes I, III and IV. In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderatel...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1989-09, Vol.163 (3), p.1450-1455 |
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| container_issue | 3 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 163 |
| creator | Mizuno, Yoshikuni Ohta, Shigeo Tanaka, Masashi Takamiya, Shinzaburo Suzuki, Keiji Sato, Takeshi Oya, Hiroshi Ozawa, Takayuki Kagawa, Yasuo |
| description | Immunoblotting studies on mitochondria prepared from the striata of patients who died of Parkinson's disease were performed using specific antisera against Complexes I, III and IV. In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderately to markedly decreased. No clear difference was noted in immunoblotting studies on subunits of Complexes III and IV between the control and Parkinson's disease. Deficiencies in Complex I subunits seem to be one of the most important clues to elucidate pathogenesis of Parkinson's disease. |
| doi_str_mv | 10.1016/0006-291X(89)91141-8 |
| format | Article |
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In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderately to markedly decreased. No clear difference was noted in immunoblotting studies on subunits of Complexes III and IV between the control and Parkinson's disease. Deficiencies in Complex I subunits seem to be one of the most important clues to elucidate pathogenesis of Parkinson's disease.</description><subject>Corpus Striatum - enzymology</subject><subject>Electron Transport Complex III - isolation & purification</subject><subject>Electron Transport Complex IV - isolation & purification</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Macromolecular Substances</subject><subject>Mitochondria - enzymology</subject><subject>NAD(P)H Dehydrogenase (Quinone)</subject><subject>Oxygen Consumption</subject><subject>Parkinson Disease - enzymology</subject><subject>Quinone Reductases - deficiency</subject><subject>Quinone Reductases - isolation & purification</subject><subject>Quinone Reductases - metabolism</subject><subject>Reference Values</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQgIMouq7-A4WcfByqk7RNk4sg6xMERRS8hWw6ZaO77Zppxf33dt3FozDDHOabGeZj7EDAmQChzgFAJdKItxNtTo0QmUj0BhsIMJBIAdkmG_whO2yX6B2gp5TZZtsyz4U0MGDPV1gFH7Duk3io-aiZzaf4ze85deOuDi3xpuLtBHlEmofo2iYuuJ-4nu3jycWPUFNTHxMvA6Ej3GNblZsS7q_rkL3eXL-M7pKHx9v70eVD4rMiaxPjyjFkqdNa58abClwlnDRFqotCKVVC6kRWeg-5U1gYAV6q3CsNWkkvU5cO2dFq7zw2nx1Sa2eBPE6nrsamI1sYKYo8Vz2YrUAfG6KIlZ3HMHNxYQXYpUq79GSXnqw29lel1f3Y4Xp_N55h-Te0dtf3L1Z97J_8Chgt_YrEMkT0rS2b8P-BH7oIgj8</recordid><startdate>19890929</startdate><enddate>19890929</enddate><creator>Mizuno, Yoshikuni</creator><creator>Ohta, Shigeo</creator><creator>Tanaka, Masashi</creator><creator>Takamiya, Shinzaburo</creator><creator>Suzuki, Keiji</creator><creator>Sato, Takeshi</creator><creator>Oya, Hiroshi</creator><creator>Ozawa, Takayuki</creator><creator>Kagawa, Yasuo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890929</creationdate><title>Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease</title><author>Mizuno, Yoshikuni ; 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| ispartof | Biochemical and biophysical research communications, 1989-09, Vol.163 (3), p.1450-1455 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Corpus Striatum - enzymology Electron Transport Complex III - isolation & purification Electron Transport Complex IV - isolation & purification Humans Immunoblotting Macromolecular Substances Mitochondria - enzymology NAD(P)H Dehydrogenase (Quinone) Oxygen Consumption Parkinson Disease - enzymology Quinone Reductases - deficiency Quinone Reductases - isolation & purification Quinone Reductases - metabolism Reference Values |
| title | Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease |
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