Phenotypic and Immunohistological Analyses of the Human Adult Thymus: Evidence for an Active Thymus during Adult Life
We analyzed cellular content of thymic samples from 26 human healthy donors, ranging from 1 week postnatal to 49 years old. Our results showed that there was an overall decrease in cellular density, beginning early during life, but with two peaks of cellular density, at 9 months and 10 years of age....
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| Veröffentlicht in: | Cellular immunology 1997-07, Vol.179 (1), p.30-40 |
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| container_title | Cellular immunology |
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| creator | Bertho, Jean-Marc Demarquay, Christelle Moulian, Nathalie Van Der Meeren, Anne Berrih-Aknin, Sonia Gourmelon, Patrick |
| description | We analyzed cellular content of thymic samples from 26 human healthy donors, ranging from 1 week postnatal to 49 years old. Our results showed that there was an overall decrease in cellular density, beginning early during life, but with two peaks of cellular density, at 9 months and 10 years of age. Histological and immunohistological analyses showed that variations in cellular density were correlated with the morphological changes observed during thymic involution, namely the enlargement of interlobular trabeculae and the development of adipocytic tissue. However, the adult thymus still contained thymocytes, up to 49 years. Phenotypic analysis showed no significant variations according to the age of donors in the distribution of the main thymocyte subsets, both precursors and more mature cells. These results suggest that the human thymus remains active during adult life. |
| doi_str_mv | 10.1006/cimm.1997.1148 |
| format | Article |
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Our results showed that there was an overall decrease in cellular density, beginning early during life, but with two peaks of cellular density, at 9 months and 10 years of age. Histological and immunohistological analyses showed that variations in cellular density were correlated with the morphological changes observed during thymic involution, namely the enlargement of interlobular trabeculae and the development of adipocytic tissue. However, the adult thymus still contained thymocytes, up to 49 years. Phenotypic analysis showed no significant variations according to the age of donors in the distribution of the main thymocyte subsets, both precursors and more mature cells. 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These results suggest that the human thymus remains active during adult life.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cell Count</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunophenotyping</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Lymphocytes - cytology</subject><subject>Male</subject><subject>T-Lymphocyte Subsets</subject><subject>Thymus Gland - cytology</subject><subject>Thymus Gland - immunology</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTGP1DAUhC0EOpaDlg7JFV2W5zgbx3Sr08GdtBIUR2059vOtURwvdrzS_vtLtBEdonrFfDN6miHkI4MtA2i_GB_Clkkptow13SuyYSChqlnLX5MNAHRVJxr5lrzL-TfAzEi4ITey3knRyg0pP484xuly8obq0dLHEMoYjz5PcYjP3uiB7kc9XDJmGh2djkgfStAj3dsyTPTpeAklf6X3Z29xNEhdTHRRzeTPuMrUluTH59Vy8A7fkzdODxk_rPeW_Pp2_3T3UB1-fH-82x8qwwVMFRed6129E72ppRNypznwumay0do2jtfILHem7RnKZmkDJe-h3yFz6GzT81vy-Zp7SvFPwTyp4LPBYdAjxpKVkDUT0PD_gqyda22hncHtFTQp5pzQqVPyQaeLYqCWF9QyiFoGUcsgs-HTmlz6gPYvvi4w691Vx7mHs8eksvFLldYnNJOy0f8r-gVilps1</recordid><startdate>19970710</startdate><enddate>19970710</enddate><creator>Bertho, Jean-Marc</creator><creator>Demarquay, Christelle</creator><creator>Moulian, Nathalie</creator><creator>Van Der Meeren, Anne</creator><creator>Berrih-Aknin, Sonia</creator><creator>Gourmelon, Patrick</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970710</creationdate><title>Phenotypic and Immunohistological Analyses of the Human Adult Thymus: Evidence for an Active Thymus during Adult Life</title><author>Bertho, Jean-Marc ; Demarquay, Christelle ; Moulian, Nathalie ; Van Der Meeren, Anne ; Berrih-Aknin, Sonia ; Gourmelon, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-378fbf257bc29f795a30322194aad4f32e1d3fc6b1e941006e93b0b5e1fefd4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cell Count</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunophenotyping</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lymphocytes - cytology</topic><topic>Male</topic><topic>T-Lymphocyte Subsets</topic><topic>Thymus Gland - cytology</topic><topic>Thymus Gland - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bertho, Jean-Marc</creatorcontrib><creatorcontrib>Demarquay, Christelle</creatorcontrib><creatorcontrib>Moulian, Nathalie</creatorcontrib><creatorcontrib>Van Der Meeren, Anne</creatorcontrib><creatorcontrib>Berrih-Aknin, Sonia</creatorcontrib><creatorcontrib>Gourmelon, Patrick</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bertho, Jean-Marc</au><au>Demarquay, Christelle</au><au>Moulian, Nathalie</au><au>Van Der Meeren, Anne</au><au>Berrih-Aknin, Sonia</au><au>Gourmelon, Patrick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenotypic and Immunohistological Analyses of the Human Adult Thymus: Evidence for an Active Thymus during Adult Life</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1997-07-10</date><risdate>1997</risdate><volume>179</volume><issue>1</issue><spage>30</spage><epage>40</epage><pages>30-40</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>We analyzed cellular content of thymic samples from 26 human healthy donors, ranging from 1 week postnatal to 49 years old. Our results showed that there was an overall decrease in cellular density, beginning early during life, but with two peaks of cellular density, at 9 months and 10 years of age. Histological and immunohistological analyses showed that variations in cellular density were correlated with the morphological changes observed during thymic involution, namely the enlargement of interlobular trabeculae and the development of adipocytic tissue. However, the adult thymus still contained thymocytes, up to 49 years. Phenotypic analysis showed no significant variations according to the age of donors in the distribution of the main thymocyte subsets, both precursors and more mature cells. These results suggest that the human thymus remains active during adult life.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9259769</pmid><doi>10.1006/cimm.1997.1148</doi><tpages>11</tpages></addata></record> |
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| ispartof | Cellular immunology, 1997-07, Vol.179 (1), p.30-40 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Cell Count Child Child, Preschool Female Hematopoietic Stem Cells - cytology Humans Immunoenzyme Techniques Immunophenotyping Infant Infant, Newborn Lymphocytes - cytology Male T-Lymphocyte Subsets Thymus Gland - cytology Thymus Gland - immunology |
| title | Phenotypic and Immunohistological Analyses of the Human Adult Thymus: Evidence for an Active Thymus during Adult Life |
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