Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

The PATCHED (PTC) gene encodes a Sonic hedgehog (Shh) receptor and a tumor suppressor protein that is defective in basal cell nevus syndrome (BCNS). Functions of PTC were investigated by inactivating the mouse gene. Mice homozygous for the ptc mutation died during embryogenesis and were found to hav...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-08, Vol.277 (5329), p.1109-1113
Hauptverfasser:	Goodrich, Lisa V., Milenković, Ljiljana, Higgins, Kay M., Scott, Matthew P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Multiple - genetics Animals Biological and medical sciences Body Patterning Cell Lineage Cell nucleus Cells Central Nervous System - cytology Central Nervous System - embryology Cerebellar Neoplasms - genetics Cerebellar Neoplasms - pathology Cerebellum Classical genetics, quantitative genetics, hybrids Congenital Impairments Ectoderm - metabolism Embryological research Embryology, Experimental Embryos Endoderm - metabolism Exons Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Genes Genes, Tumor Suppressor Genetic mutation Genetics of eukaryotes. Biological and molecular evolution Heterozygote Homozygote Individualized Instruction Intracellular Signaling Peptides and Proteins Medulloblastoma Medulloblastoma - genetics Medulloblastoma - pathology Membrane Proteins - genetics Membrane Proteins - physiology Mesoderm - metabolism Mice Mice, Inbred C57BL Mutation Neurons Oncogene Proteins - genetics Patched Receptors Patched-1 Receptor Purkinje cells Receptors, Cell Surface Trans-Activators Transcription Factors - genetics Tumors Vertebrata Zinc Finger Protein GLI1
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