Fetal and adult hair follicle: An immunohistochemical study of anticytokeratin antibodies in formalin-fixed and paraffin-embedded tissue
The expression of cytokeratins (CK), involucrin, vimentin, CD34, and alpha-smooth-muscle actin was studied in fetal and adult hair follicles. The first stage of the developing hair follicle is characterized by palisaded, elongated epithelial cells budding from the epidermal basal layer. These cells...
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| Veröffentlicht in: | The American journal of dermatopathology 1997-08, Vol.19 (4), p.334-340 |
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| creator | SCHIRREN, C. G BURGDORF, W. H. C SANDER, C. A PLEWIG, G |
| description | The expression of cytokeratins (CK), involucrin, vimentin, CD34, and alpha-smooth-muscle actin was studied in fetal and adult hair follicles. The first stage of the developing hair follicle is characterized by palisaded, elongated epithelial cells budding from the epidermal basal layer. These cells express CK5/6, CK14, CK17, CK19, and vimentin. During the following weeks of gestation, different structures in the developing hair follicle can be identified and characterized. The matrical cells display only CK19. The keratinocytes of the outer root sheath express CK5/6, CK14, CK17, CK19, and involucrin; those of the inner root sheath, CK4, CK18, and involucrin; those of the isthmus, the same profile as the ORS. In the infundibulum, the basal-layer keratinocytes express CK5/6, CK14, CK17, and CK19, whereas in the suprabasal layers CK1, CK4, CK10, CK14, and CK17 are seen. The adult hair follicle in anagen fails to express CK19 in the matrical cells and isthmus and both CK17 and CK19 in the infundibulum. These profiles of intermediate filaments and other markers appear to be potentially useful in categorizing neoplasms with apparent follicular differentiation. |
| doi_str_mv | 10.1097/00000372-199708000-00004 |
| format | Article |
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G ; BURGDORF, W. H. C ; SANDER, C. A ; PLEWIG, G</creator><creatorcontrib>SCHIRREN, C. G ; BURGDORF, W. H. C ; SANDER, C. A ; PLEWIG, G</creatorcontrib><description>The expression of cytokeratins (CK), involucrin, vimentin, CD34, and alpha-smooth-muscle actin was studied in fetal and adult hair follicles. The first stage of the developing hair follicle is characterized by palisaded, elongated epithelial cells budding from the epidermal basal layer. These cells express CK5/6, CK14, CK17, CK19, and vimentin. During the following weeks of gestation, different structures in the developing hair follicle can be identified and characterized. The matrical cells display only CK19. The keratinocytes of the outer root sheath express CK5/6, CK14, CK17, CK19, and involucrin; those of the inner root sheath, CK4, CK18, and involucrin; those of the isthmus, the same profile as the ORS. In the infundibulum, the basal-layer keratinocytes express CK5/6, CK14, CK17, and CK19, whereas in the suprabasal layers CK1, CK4, CK10, CK14, and CK17 are seen. The adult hair follicle in anagen fails to express CK19 in the matrical cells and isthmus and both CK17 and CK19 in the infundibulum. These profiles of intermediate filaments and other markers appear to be potentially useful in categorizing neoplasms with apparent follicular differentiation.</description><identifier>ISSN: 0193-1091</identifier><identifier>EISSN: 1533-0311</identifier><identifier>DOI: 10.1097/00000372-199708000-00004</identifier><identifier>PMID: 9261467</identifier><identifier>CODEN: AJODDB</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Actins - analysis ; Adult ; Antibodies ; Antigens, CD34 - analysis ; Biological and medical sciences ; Dermatology ; Epidermis - anatomy & histology ; Epidermis - embryology ; Epithelium - anatomy & histology ; Epithelium - embryology ; Fetus ; Fixatives ; Formaldehyde ; Gene Expression Regulation ; Gene Expression Regulation, Developmental ; Hair Follicle - anatomy & histology ; Hair Follicle - embryology ; Humans ; Immunohistochemistry ; Intermediate Filaments - ultrastructure ; Investigative techniques, diagnostic techniques (general aspects) ; Keratinocytes - cytology ; Keratins - analysis ; Keratins - genetics ; Medical sciences ; Paraffin Embedding ; Pathology. 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G</creatorcontrib><creatorcontrib>BURGDORF, W. H. C</creatorcontrib><creatorcontrib>SANDER, C. A</creatorcontrib><creatorcontrib>PLEWIG, G</creatorcontrib><title>Fetal and adult hair follicle: An immunohistochemical study of anticytokeratin antibodies in formalin-fixed and paraffin-embedded tissue</title><title>The American journal of dermatopathology</title><addtitle>Am J Dermatopathol</addtitle><description>The expression of cytokeratins (CK), involucrin, vimentin, CD34, and alpha-smooth-muscle actin was studied in fetal and adult hair follicles. The first stage of the developing hair follicle is characterized by palisaded, elongated epithelial cells budding from the epidermal basal layer. These cells express CK5/6, CK14, CK17, CK19, and vimentin. During the following weeks of gestation, different structures in the developing hair follicle can be identified and characterized. The matrical cells display only CK19. The keratinocytes of the outer root sheath express CK5/6, CK14, CK17, CK19, and involucrin; those of the inner root sheath, CK4, CK18, and involucrin; those of the isthmus, the same profile as the ORS. In the infundibulum, the basal-layer keratinocytes express CK5/6, CK14, CK17, and CK19, whereas in the suprabasal layers CK1, CK4, CK10, CK14, and CK17 are seen. The adult hair follicle in anagen fails to express CK19 in the matrical cells and isthmus and both CK17 and CK19 in the infundibulum. These profiles of intermediate filaments and other markers appear to be potentially useful in categorizing neoplasms with apparent follicular differentiation.</description><subject>Actins - analysis</subject><subject>Adult</subject><subject>Antibodies</subject><subject>Antigens, CD34 - analysis</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Epidermis - anatomy & histology</subject><subject>Epidermis - embryology</subject><subject>Epithelium - anatomy & histology</subject><subject>Epithelium - embryology</subject><subject>Fetus</subject><subject>Fixatives</subject><subject>Formaldehyde</subject><subject>Gene Expression Regulation</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Hair Follicle - anatomy & histology</subject><subject>Hair Follicle - embryology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intermediate Filaments - ultrastructure</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Keratinocytes - cytology</subject><subject>Keratins - analysis</subject><subject>Keratins - genetics</subject><subject>Medical sciences</subject><subject>Paraffin Embedding</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Protein Precursors - analysis</subject><subject>Tissue Fixation</subject><subject>Vimentin - analysis</subject><issn>0193-1091</issn><issn>1533-0311</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UcFu3CAQRVWqZJP2EypxqHJzAsY2prcoappIkXJpz9YYBi0tNhvAUvcP-tnBm-1ygffmvRnxhhDK2Q1nSt6y9QhZV1wpyfoCqpVpPpANb4WomOD8jGwYV6IqBn5BLlP6zRive9aek3NVd7zp5Ib8e8AMnsJsKJjFZ7oFF6kN3jvt8Ru9m6mbpmUOW5dy0FucnC76lBezp8EWY3Z6n8MfjJDdfMBjMA4TLciGOIF3c2XdXzSHKTuIYG2hcBrRmMJml9KCn8hHCz7h5-N9RX49fP95_1g9v_x4ur97rnTdN7lqeibHxvaoykMpLCSgAKXYaMG2QhnbtbKuW61LLi0oXkD5am2LbGStuCLX7313MbwumPIwuaTRe5gxLGmQapV3q7B_F-oYUopoh110E8T9wNmwLmH4v4ThtIQD1RTrl-OMZZzQnIzH1Ev967EOqaRpI8zapZOslrIrfcUb4_-Q0Q</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>SCHIRREN, C. G</creator><creator>BURGDORF, W. H. C</creator><creator>SANDER, C. A</creator><creator>PLEWIG, G</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Fetal and adult hair follicle: An immunohistochemical study of anticytokeratin antibodies in formalin-fixed and paraffin-embedded tissue</title><author>SCHIRREN, C. G ; BURGDORF, W. H. C ; SANDER, C. A ; PLEWIG, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-4807b4f8e980799e284ae3a990bfaf539df657225cc7085a917221462fae3b053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Actins - analysis</topic><topic>Adult</topic><topic>Antibodies</topic><topic>Antigens, CD34 - analysis</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Epidermis - anatomy & histology</topic><topic>Epidermis - embryology</topic><topic>Epithelium - anatomy & histology</topic><topic>Epithelium - embryology</topic><topic>Fetus</topic><topic>Fixatives</topic><topic>Formaldehyde</topic><topic>Gene Expression Regulation</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Hair Follicle - anatomy & histology</topic><topic>Hair Follicle - embryology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intermediate Filaments - ultrastructure</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Keratinocytes - cytology</topic><topic>Keratins - analysis</topic><topic>Keratins - genetics</topic><topic>Medical sciences</topic><topic>Paraffin Embedding</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Protein Precursors - analysis</topic><topic>Tissue Fixation</topic><topic>Vimentin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHIRREN, C. G</creatorcontrib><creatorcontrib>BURGDORF, W. H. C</creatorcontrib><creatorcontrib>SANDER, C. A</creatorcontrib><creatorcontrib>PLEWIG, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of dermatopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHIRREN, C. G</au><au>BURGDORF, W. H. C</au><au>SANDER, C. A</au><au>PLEWIG, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal and adult hair follicle: An immunohistochemical study of anticytokeratin antibodies in formalin-fixed and paraffin-embedded tissue</atitle><jtitle>The American journal of dermatopathology</jtitle><addtitle>Am J Dermatopathol</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>19</volume><issue>4</issue><spage>334</spage><epage>340</epage><pages>334-340</pages><issn>0193-1091</issn><eissn>1533-0311</eissn><coden>AJODDB</coden><abstract>The expression of cytokeratins (CK), involucrin, vimentin, CD34, and alpha-smooth-muscle actin was studied in fetal and adult hair follicles. The first stage of the developing hair follicle is characterized by palisaded, elongated epithelial cells budding from the epidermal basal layer. These cells express CK5/6, CK14, CK17, CK19, and vimentin. During the following weeks of gestation, different structures in the developing hair follicle can be identified and characterized. The matrical cells display only CK19. The keratinocytes of the outer root sheath express CK5/6, CK14, CK17, CK19, and involucrin; those of the inner root sheath, CK4, CK18, and involucrin; those of the isthmus, the same profile as the ORS. In the infundibulum, the basal-layer keratinocytes express CK5/6, CK14, CK17, and CK19, whereas in the suprabasal layers CK1, CK4, CK10, CK14, and CK17 are seen. The adult hair follicle in anagen fails to express CK19 in the matrical cells and isthmus and both CK17 and CK19 in the infundibulum. These profiles of intermediate filaments and other markers appear to be potentially useful in categorizing neoplasms with apparent follicular differentiation.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9261467</pmid><doi>10.1097/00000372-199708000-00004</doi><tpages>7</tpages></addata></record> |
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| subjects | Actins - analysis Adult Antibodies Antigens, CD34 - analysis Biological and medical sciences Dermatology Epidermis - anatomy & histology Epidermis - embryology Epithelium - anatomy & histology Epithelium - embryology Fetus Fixatives Formaldehyde Gene Expression Regulation Gene Expression Regulation, Developmental Hair Follicle - anatomy & histology Hair Follicle - embryology Humans Immunohistochemistry Intermediate Filaments - ultrastructure Investigative techniques, diagnostic techniques (general aspects) Keratinocytes - cytology Keratins - analysis Keratins - genetics Medical sciences Paraffin Embedding Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Protein Precursors - analysis Tissue Fixation Vimentin - analysis |
| title | Fetal and adult hair follicle: An immunohistochemical study of anticytokeratin antibodies in formalin-fixed and paraffin-embedded tissue |
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