Identification of Monocyte Chemotactic Activity Produced by Malignant Cells

Human malignant cells secrete low molecular size proteins that attract peripheral blood monocytes and may be responsible for the accumulation of tumor-associated macrophages observed in vivo. Similar chemotactic proteins are secreted by cultured vascular smooth muscle cells. The predominant monocyte...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1989-09, Vol.245 (4925), p.1490-1493
Hauptverfasser:	Graves, D. T., Jiang, Y. L., Williamson, M. J., Valente, A. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiserum Biological and medical sciences Biology Causes of Cell lines Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chemotactic factors Chemotactic Factors - biosynthesis Chemotaxis Chemotaxis, Leukocyte Disease Fundamental and applied biological sciences. Psychology Humans Macrophages Molecular and cellular biology Monocytes Monocytes - cytology Muscle, Smooth, Vascular - metabolism Osteosarcoma Papio Physiological aspects Precipitin Tests Proteins Rabbits Smooth muscle myocytes Tumor Cells, Cultured - metabolism Tumors
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