Influence of hemodynamic changes on neuroendocrine response in acute heart failure
We studied 15 patients with acute deterioration of chronic left ventricular heart failure. We compared the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics on plasma concentration of epinephrine, norepin...
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| Veröffentlicht in: | International journal of cardiology 1997-08, Vol.60 (3), p.263-271 |
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| creator | Pohar, Bojan Horvat, Matija |
| description | We studied 15 patients with acute deterioration of chronic left ventricular heart failure. We compared the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics on plasma concentration of epinephrine, norepinephrine, aldosterone and renin activity. Reduction of ventricular filling pressures with glyceryl trinitrate had no influence on plasma concentrations of epinephrine, norepinephrine, aldosterone and renin activity. After reduction of ventricular filling pressures with diuretics plasma concentrations of epinephrine, norepinephrine and aldosterone decreased, while plasma renin activity did not change. We conclude that there is a difference in the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics, on neuroendocrine response in patients with acute deterioration of left ventricular heart failure. Thus some of the neuroendocrine effects of glyceryl trinitrate are likely to be different from those of diuretics, though that they both produce a reduction in left ventricular filling pressure. |
| doi_str_mv | 10.1016/S0167-5273(97)00075-2 |
| format | Article |
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We compared the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics on plasma concentration of epinephrine, norepinephrine, aldosterone and renin activity. Reduction of ventricular filling pressures with glyceryl trinitrate had no influence on plasma concentrations of epinephrine, norepinephrine, aldosterone and renin activity. After reduction of ventricular filling pressures with diuretics plasma concentrations of epinephrine, norepinephrine and aldosterone decreased, while plasma renin activity did not change. We conclude that there is a difference in the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics, on neuroendocrine response in patients with acute deterioration of left ventricular heart failure. Thus some of the neuroendocrine effects of glyceryl trinitrate are likely to be different from those of diuretics, though that they both produce a reduction in left ventricular filling pressure.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/S0167-5273(97)00075-2</identifier><identifier>PMID: 9261637</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acute Disease ; Aged ; Aldosterone - blood ; Biological and medical sciences ; Cardiac Catheterization ; Cardiology. Vascular system ; Congestive heart failure ; Diuretics ; Diuretics - therapeutic use ; Epinephrine - blood ; Female ; Glyceryl trinitrate ; Heart ; Heart Failure - blood ; Heart Failure - drug therapy ; Heart Failure - physiopathology ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Heart Rate - drug effects ; Heart Rate - physiology ; Humans ; Male ; Medical sciences ; Neurohumoral activity ; Nitroglycerin - therapeutic use ; Norepinephrine - blood ; Radioimmunoassay ; Renin - blood ; Vasodilator Agents - therapeutic use ; Ventricular Dysfunction - blood ; Ventricular Dysfunction - drug therapy ; Ventricular Dysfunction - physiopathology ; Ventricular filling pressures ; Ventricular Pressure - drug effects ; Ventricular Pressure - physiology</subject><ispartof>International journal of cardiology, 1997-08, Vol.60 (3), p.263-271</ispartof><rights>1997 Elsevier Science Ireland Ltd</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-e828cdc26c1a94c5926612d180e6993fbcacbd020ba6e0214f431ecb7870063a3</citedby><cites>FETCH-LOGICAL-c389t-e828cdc26c1a94c5926612d180e6993fbcacbd020ba6e0214f431ecb7870063a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167527397000752$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2756639$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9261637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pohar, Bojan</creatorcontrib><creatorcontrib>Horvat, Matija</creatorcontrib><title>Influence of hemodynamic changes on neuroendocrine response in acute heart failure</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>We studied 15 patients with acute deterioration of chronic left ventricular heart failure. We compared the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics on plasma concentration of epinephrine, norepinephrine, aldosterone and renin activity. Reduction of ventricular filling pressures with glyceryl trinitrate had no influence on plasma concentrations of epinephrine, norepinephrine, aldosterone and renin activity. After reduction of ventricular filling pressures with diuretics plasma concentrations of epinephrine, norepinephrine and aldosterone decreased, while plasma renin activity did not change. We conclude that there is a difference in the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics, on neuroendocrine response in patients with acute deterioration of left ventricular heart failure. Thus some of the neuroendocrine effects of glyceryl trinitrate are likely to be different from those of diuretics, though that they both produce a reduction in left ventricular filling pressure.</description><subject>Acute Disease</subject><subject>Aged</subject><subject>Aldosterone - blood</subject><subject>Biological and medical sciences</subject><subject>Cardiac Catheterization</subject><subject>Cardiology. Vascular system</subject><subject>Congestive heart failure</subject><subject>Diuretics</subject><subject>Diuretics - therapeutic use</subject><subject>Epinephrine - blood</subject><subject>Female</subject><subject>Glyceryl trinitrate</subject><subject>Heart</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - physiopathology</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurohumoral activity</subject><subject>Nitroglycerin - therapeutic use</subject><subject>Norepinephrine - blood</subject><subject>Radioimmunoassay</subject><subject>Renin - blood</subject><subject>Vasodilator Agents - therapeutic use</subject><subject>Ventricular Dysfunction - blood</subject><subject>Ventricular Dysfunction - drug therapy</subject><subject>Ventricular Dysfunction - physiopathology</subject><subject>Ventricular filling pressures</subject><subject>Ventricular Pressure - drug effects</subject><subject>Ventricular Pressure - physiology</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpSDZpf0JAh1CSg1N92JJ1KiHkCwKBtD0LeTxuVGxpK9mB_Ptqs8tec5k5zPPODA8hp5xdcsbV95-l6KoRWp4bfcEY000lPpEVb3Vdcd3Un8lqjxyR45z_Fqg2pj0kh0YorqRekeeHMIwLBkAaB_qCU-zfgps8UHhx4Q9mGgMNuKSIoY-QfECaMK9jyEh9oA6WGUvOpZkOzo9Lwi_kYHBjxq-7fkJ-3978ur6vHp_uHq6vHiuQrZkrbEULPQgF3JkamvKS4qLnLUNljBw6cND1TLDOKWSC10MtOUKnW82Ykk6ekG_bvesU_y2YZzv5DDiOLmBcstVGcFnWFrDZgpBizgkHu05-cunNcmY3Lu27S7sRZY227y7tJne6O7B0E_b71E5emZ_t5i6DG4fkAvi8x4RulJKmYD-2GBYZrx6TzeA3xnufEGbbR__BI_8B7oKQxQ</recordid><startdate>19970808</startdate><enddate>19970808</enddate><creator>Pohar, Bojan</creator><creator>Horvat, Matija</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970808</creationdate><title>Influence of hemodynamic changes on neuroendocrine response in acute heart failure</title><author>Pohar, Bojan ; Horvat, Matija</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-e828cdc26c1a94c5926612d180e6993fbcacbd020ba6e0214f431ecb7870063a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Aldosterone - blood</topic><topic>Biological and medical sciences</topic><topic>Cardiac Catheterization</topic><topic>Cardiology. Vascular system</topic><topic>Congestive heart failure</topic><topic>Diuretics</topic><topic>Diuretics - therapeutic use</topic><topic>Epinephrine - blood</topic><topic>Female</topic><topic>Glyceryl trinitrate</topic><topic>Heart</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - physiopathology</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Heart Rate - drug effects</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurohumoral activity</topic><topic>Nitroglycerin - therapeutic use</topic><topic>Norepinephrine - blood</topic><topic>Radioimmunoassay</topic><topic>Renin - blood</topic><topic>Vasodilator Agents - therapeutic use</topic><topic>Ventricular Dysfunction - blood</topic><topic>Ventricular Dysfunction - drug therapy</topic><topic>Ventricular Dysfunction - physiopathology</topic><topic>Ventricular filling pressures</topic><topic>Ventricular Pressure - drug effects</topic><topic>Ventricular Pressure - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pohar, Bojan</creatorcontrib><creatorcontrib>Horvat, Matija</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pohar, Bojan</au><au>Horvat, Matija</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of hemodynamic changes on neuroendocrine response in acute heart failure</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>1997-08-08</date><risdate>1997</risdate><volume>60</volume><issue>3</issue><spage>263</spage><epage>271</epage><pages>263-271</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>We studied 15 patients with acute deterioration of chronic left ventricular heart failure. We compared the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics on plasma concentration of epinephrine, norepinephrine, aldosterone and renin activity. Reduction of ventricular filling pressures with glyceryl trinitrate had no influence on plasma concentrations of epinephrine, norepinephrine, aldosterone and renin activity. After reduction of ventricular filling pressures with diuretics plasma concentrations of epinephrine, norepinephrine and aldosterone decreased, while plasma renin activity did not change. We conclude that there is a difference in the influence of reduction of ventricular filling pressures with glyceryl trinitrate versus reduction of ventricular filling pressures with diuretics, on neuroendocrine response in patients with acute deterioration of left ventricular heart failure. Thus some of the neuroendocrine effects of glyceryl trinitrate are likely to be different from those of diuretics, though that they both produce a reduction in left ventricular filling pressure.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9261637</pmid><doi>10.1016/S0167-5273(97)00075-2</doi><tpages>9</tpages></addata></record> |
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| subjects | Acute Disease Aged Aldosterone - blood Biological and medical sciences Cardiac Catheterization Cardiology. Vascular system Congestive heart failure Diuretics Diuretics - therapeutic use Epinephrine - blood Female Glyceryl trinitrate Heart Heart Failure - blood Heart Failure - drug therapy Heart Failure - physiopathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Rate - drug effects Heart Rate - physiology Humans Male Medical sciences Neurohumoral activity Nitroglycerin - therapeutic use Norepinephrine - blood Radioimmunoassay Renin - blood Vasodilator Agents - therapeutic use Ventricular Dysfunction - blood Ventricular Dysfunction - drug therapy Ventricular Dysfunction - physiopathology Ventricular filling pressures Ventricular Pressure - drug effects Ventricular Pressure - physiology |
| title | Influence of hemodynamic changes on neuroendocrine response in acute heart failure |
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