Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies
Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpre...
Gespeichert in:
| Veröffentlicht in: | Psychopharmacology 1997-07, Vol.132 (2), p.107-124 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 124 |
|---|---|
| container_issue | 2 |
| container_start_page | 107 |
| container_title | Psychopharmacology |
| container_volume | 132 |
| creator | Crawley, J N Belknap, J K Collins, A Crabbe, J C Frankel, W Henderson, N Hitzemann, R J Maxson, S C Miner, L L Silva, A J Wehner, J M Wynshaw-Boris, A Paylor, R |
| description | Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases. |
| doi_str_mv | 10.1007/s002130050327 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79212800</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16466463</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-e098cb09d407a493f89b5df5d809cd60bb2286fd57d4b41e6004135fb7de2c3b3</originalsourceid><addsrcrecordid>eNqNkU1r3DAQhkVo2Gy2PeYYMBRyczOSbEnOrVmStrCQS3I2-hizCrblSnYg_z4KuxTSSzsMDAzPDPPOS8gFhW8UQF4nAEY5QA2cyROyphVnJQPJPpE1AOclp7U6I-cpPUOOSlUrsmqYEALUmuAt7vWLD1H3xbTHMcyvE6YidIUfTURXDGFJWKQ5aj-mm8IPU--tnn0YU6FHV0S0YRhwdMdeF2Ke6dEuvY55bnEe02dy2uk-4Zdj3ZCn-7vH7c9y9_Dj1_b7rrRcqrlEaJQ10LgKpK4a3qnG1K6rnYLGOgHGMKZE52rpKlNRFFkO5XVnpENmueEbcnXYO8Xwe8E0t4NPFvtej5h1tLJhlKn8lX-BVFQiJ_8PML86n5vBr3-Bz2GJY1bbckqlbGouVKbKA2VjSCli107RDzq-thTadzvbD3Zm_vK4dTEDuj_00T_-Bm3GmrY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3117795368</pqid></control><display><type>article</type><title>Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Crawley, J N ; Belknap, J K ; Collins, A ; Crabbe, J C ; Frankel, W ; Henderson, N ; Hitzemann, R J ; Maxson, S C ; Miner, L L ; Silva, A J ; Wehner, J M ; Wynshaw-Boris, A ; Paylor, R</creator><creatorcontrib>Crawley, J N ; Belknap, J K ; Collins, A ; Crabbe, J C ; Frankel, W ; Henderson, N ; Hitzemann, R J ; Maxson, S C ; Miner, L L ; Silva, A J ; Wehner, J M ; Wynshaw-Boris, A ; Paylor, R</creatorcontrib><description>Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s002130050327</identifier><identifier>PMID: 9266608</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Animal models ; Animals ; Anti-Anxiety Agents - pharmacology ; Antipsychotic Agents - pharmacology ; Antipsychotics ; Anxiolytics ; Behavior, Animal - drug effects ; Cell culture ; Cocaine ; Cocaine - pharmacology ; Drug development ; Embryo cells ; Embryogenesis ; Ethanol - pharmacology ; Genetic disorders ; Genetics, Behavioral ; Inbreeding ; Mice ; Mice, Inbred Strains - genetics ; Mice, Inbred Strains - physiology ; Nicotine - pharmacology ; Open-field behavior ; Opioids ; Parental behavior ; Phenotype ; Phenotypes ; Progenitor cells ; Sexual behavior ; Stem cells ; Transgenic mice</subject><ispartof>Psychopharmacology, 1997-07, Vol.132 (2), p.107-124</ispartof><rights>Springer-Verlag Berlin Heidelberg 1997.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-e098cb09d407a493f89b5df5d809cd60bb2286fd57d4b41e6004135fb7de2c3b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9266608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crawley, J N</creatorcontrib><creatorcontrib>Belknap, J K</creatorcontrib><creatorcontrib>Collins, A</creatorcontrib><creatorcontrib>Crabbe, J C</creatorcontrib><creatorcontrib>Frankel, W</creatorcontrib><creatorcontrib>Henderson, N</creatorcontrib><creatorcontrib>Hitzemann, R J</creatorcontrib><creatorcontrib>Maxson, S C</creatorcontrib><creatorcontrib>Miner, L L</creatorcontrib><creatorcontrib>Silva, A J</creatorcontrib><creatorcontrib>Wehner, J M</creatorcontrib><creatorcontrib>Wynshaw-Boris, A</creatorcontrib><creatorcontrib>Paylor, R</creatorcontrib><title>Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies</title><title>Psychopharmacology</title><addtitle>Psychopharmacology (Berl)</addtitle><description>Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases.</description><subject>Animal models</subject><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Antipsychotics</subject><subject>Anxiolytics</subject><subject>Behavior, Animal - drug effects</subject><subject>Cell culture</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Drug development</subject><subject>Embryo cells</subject><subject>Embryogenesis</subject><subject>Ethanol - pharmacology</subject><subject>Genetic disorders</subject><subject>Genetics, Behavioral</subject><subject>Inbreeding</subject><subject>Mice</subject><subject>Mice, Inbred Strains - genetics</subject><subject>Mice, Inbred Strains - physiology</subject><subject>Nicotine - pharmacology</subject><subject>Open-field behavior</subject><subject>Opioids</subject><subject>Parental behavior</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Progenitor cells</subject><subject>Sexual behavior</subject><subject>Stem cells</subject><subject>Transgenic mice</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1r3DAQhkVo2Gy2PeYYMBRyczOSbEnOrVmStrCQS3I2-hizCrblSnYg_z4KuxTSSzsMDAzPDPPOS8gFhW8UQF4nAEY5QA2cyROyphVnJQPJPpE1AOclp7U6I-cpPUOOSlUrsmqYEALUmuAt7vWLD1H3xbTHMcyvE6YidIUfTURXDGFJWKQ5aj-mm8IPU--tnn0YU6FHV0S0YRhwdMdeF2Ke6dEuvY55bnEe02dy2uk-4Zdj3ZCn-7vH7c9y9_Dj1_b7rrRcqrlEaJQ10LgKpK4a3qnG1K6rnYLGOgHGMKZE52rpKlNRFFkO5XVnpENmueEbcnXYO8Xwe8E0t4NPFvtej5h1tLJhlKn8lX-BVFQiJ_8PML86n5vBr3-Bz2GJY1bbckqlbGouVKbKA2VjSCli107RDzq-thTadzvbD3Zm_vK4dTEDuj_00T_-Bm3GmrY</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>Crawley, J N</creator><creator>Belknap, J K</creator><creator>Collins, A</creator><creator>Crabbe, J C</creator><creator>Frankel, W</creator><creator>Henderson, N</creator><creator>Hitzemann, R J</creator><creator>Maxson, S C</creator><creator>Miner, L L</creator><creator>Silva, A J</creator><creator>Wehner, J M</creator><creator>Wynshaw-Boris, A</creator><creator>Paylor, R</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies</title><author>Crawley, J N ; Belknap, J K ; Collins, A ; Crabbe, J C ; Frankel, W ; Henderson, N ; Hitzemann, R J ; Maxson, S C ; Miner, L L ; Silva, A J ; Wehner, J M ; Wynshaw-Boris, A ; Paylor, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-e098cb09d407a493f89b5df5d809cd60bb2286fd57d4b41e6004135fb7de2c3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Antipsychotics</topic><topic>Anxiolytics</topic><topic>Behavior, Animal - drug effects</topic><topic>Cell culture</topic><topic>Cocaine</topic><topic>Cocaine - pharmacology</topic><topic>Drug development</topic><topic>Embryo cells</topic><topic>Embryogenesis</topic><topic>Ethanol - pharmacology</topic><topic>Genetic disorders</topic><topic>Genetics, Behavioral</topic><topic>Inbreeding</topic><topic>Mice</topic><topic>Mice, Inbred Strains - genetics</topic><topic>Mice, Inbred Strains - physiology</topic><topic>Nicotine - pharmacology</topic><topic>Open-field behavior</topic><topic>Opioids</topic><topic>Parental behavior</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Progenitor cells</topic><topic>Sexual behavior</topic><topic>Stem cells</topic><topic>Transgenic mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crawley, J N</creatorcontrib><creatorcontrib>Belknap, J K</creatorcontrib><creatorcontrib>Collins, A</creatorcontrib><creatorcontrib>Crabbe, J C</creatorcontrib><creatorcontrib>Frankel, W</creatorcontrib><creatorcontrib>Henderson, N</creatorcontrib><creatorcontrib>Hitzemann, R J</creatorcontrib><creatorcontrib>Maxson, S C</creatorcontrib><creatorcontrib>Miner, L L</creatorcontrib><creatorcontrib>Silva, A J</creatorcontrib><creatorcontrib>Wehner, J M</creatorcontrib><creatorcontrib>Wynshaw-Boris, A</creatorcontrib><creatorcontrib>Paylor, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crawley, J N</au><au>Belknap, J K</au><au>Collins, A</au><au>Crabbe, J C</au><au>Frankel, W</au><au>Henderson, N</au><au>Hitzemann, R J</au><au>Maxson, S C</au><au>Miner, L L</au><au>Silva, A J</au><au>Wehner, J M</au><au>Wynshaw-Boris, A</au><au>Paylor, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies</atitle><jtitle>Psychopharmacology</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>132</volume><issue>2</issue><spage>107</spage><epage>124</epage><pages>107-124</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>9266608</pmid><doi>10.1007/s002130050327</doi><tpages>18</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacology, 1997-07, Vol.132 (2), p.107-124 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79212800 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animal models Animals Anti-Anxiety Agents - pharmacology Antipsychotic Agents - pharmacology Antipsychotics Anxiolytics Behavior, Animal - drug effects Cell culture Cocaine Cocaine - pharmacology Drug development Embryo cells Embryogenesis Ethanol - pharmacology Genetic disorders Genetics, Behavioral Inbreeding Mice Mice, Inbred Strains - genetics Mice, Inbred Strains - physiology Nicotine - pharmacology Open-field behavior Opioids Parental behavior Phenotype Phenotypes Progenitor cells Sexual behavior Stem cells Transgenic mice |
| title | Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T02%3A24%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Behavioral%20phenotypes%20of%20inbred%20mouse%20strains:%20implications%20and%20recommendations%20for%20molecular%20studies&rft.jtitle=Psychopharmacology&rft.au=Crawley,%20J%20N&rft.date=1997-07-01&rft.volume=132&rft.issue=2&rft.spage=107&rft.epage=124&rft.pages=107-124&rft.issn=0033-3158&rft.eissn=1432-2072&rft_id=info:doi/10.1007/s002130050327&rft_dat=%3Cproquest_cross%3E16466463%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3117795368&rft_id=info:pmid/9266608&rfr_iscdi=true |