Syntheses of Novel Pyridazinomorphinans by Inverse Electron Demand Cycloaddition and their Binding to μ and κ Receptors

A number of novel pyridazinomorphinans have been synthesized by the inverse electron demand Diels‐Alder reaction of various 3,6‐disubstituted 1,2,4,5‐tetrazines with enamines derived from dihydrocodeinone and with codeinone. Reduction of some of the pyridazinomorphinans did not furnish the expected...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 1997-06, Vol.330 (6), p.163-168
Hauptverfasser:	Klindert, Thilo, Stroetmann, Isabel, Seitz, Gunther, Höfner, Georg, Wanner, Klaus Th, Frenzen, Gerlinde, Eckhoff, Brigitta
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,4,5‐tetrazines 5-tetrazines Animals Benzeneacetamides Binding, Competitive Biological and medical sciences Cattle Cell Membrane - metabolism Corpus Striatum - metabolism Crystallography, X-Ray Diels-Alder reactions Diels‐Alder reactions, inverse Enkephalin, Ala-MePhe-Gly Enkephalins - metabolism Indicators and Reagents inverse Medical sciences Models, Molecular Molecular Structure Morphinans - chemical synthesis Morphinans - chemistry Morphinans - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Opioid analgesics Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Pyrazines - chemical synthesis Pyrazines - chemistry Pyrazines - pharmacology pyridazinomorphinans pyridazinomorphinans, pyrrolomorphinans Pyrrolidines - metabolism pyrrolomorphinans Radioligand Assay Receptors, Opioid, kappa - agonists Receptors, Opioid, kappa - metabolism Receptors, Opioid, mu - agonists Receptors, Opioid, mu - metabolism
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