Cellular Hypertrophy and Calcification of Embryonal Carcinoma‐Derived Chondrogenic Cell Line ATDC5 In Vitro

During the process of endochondral bone formation, proliferating chondrocytes give rise to hypertrophic cells, which then deposit a mineralized matrix to form calcified cartilage prior to replacement by bone. Previously, we reported that a clonal cell line, ATDC5, undergoes efficient chondrogenic di...

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Veröffentlicht in:	Journal of bone and mineral research 1997-08, Vol.12 (8), p.1174-1188
Hauptverfasser:	Shukunami, Chisa, Ishizeki, Kiyoto, Atsumi, Tadao, Ohta, Yoshiyuki, Suzuki, Fujio, Hiraki, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Biological and medical sciences Calcification, Physiologic - physiology Calcium - analysis Carcinoma, Embryonal - genetics Carcinoma, Embryonal - pathology Cartilage - cytology Cartilage - drug effects Cartilage - pathology Cartilage - ultrastructure Cell Differentiation - drug effects Cell Differentiation - genetics Chondrocytes - pathology Chondrocytes - physiology Chondrocytes - ultrastructure Collagen - biosynthesis Collagen - genetics Electron Probe Microanalysis Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic - genetics Glycerophosphates - chemistry Hypertrophy Mice Microscopy, Electron Nucleic Acid Hybridization Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Parathyroid Hormone - pharmacology RNA - isolation & purification RNA - metabolism Skeleton and joints Space life sciences Spectroscopy, Fourier Transform Infrared Stem Cells - pathology Stem Cells - physiology Stem Cells - ultrastructure Tumor Cells, Cultured Vertebrates: osteoarticular system, musculoskeletal system
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