Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression
In the tail suspension test (an animal model of depression) the duration of immobility during the 6 min of observation was 56.84±6.54 sec in sham-ovariectomized mice and 113.11±7.86 sec 30–32 days after ovariectomy. Estradiol (10, 100 or 1,000 μ/kg) and progesterone (50, 1,000 or 10,000 μ/kg), subcu...
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| Veröffentlicht in: | Physiology & behavior 1989-05, Vol.45 (5), p.1067-1068 |
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| container_title | Physiology & behavior |
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| creator | Bernardi, M. Vergoni, A.V. Sandrini, M. Tagliavini, S. Bertolini, A. |
| description | In the tail suspension test (an animal model of depression) the duration of immobility during the 6 min of observation was 56.84±6.54 sec in sham-ovariectomized mice and 113.11±7.86 sec 30–32 days after ovariectomy. Estradiol (10, 100 or 1,000 μ/kg) and progesterone (50, 1,000 or 10,000 μ/kg), subcutaneously injected daily 4 times before the test, restored the duration of immobility in ovariectomized mice to normal, while having no effect on sham-operated animals. On the other hand, desipramine (20 mg/kg IP 1 hr before testing) significantly reduced the duration of immobility both in ovariectomized and in sham-operated mice. These data indicate that ovarian sex hormones, while having no “antidepressant,” desipramine-like, effect on the behavior of intact adult female mice, have such an effect in ovariectomized mice, and enable the animal to cope in a “normal” way with adverse environmental situations. |
| doi_str_mv | 10.1016/0031-9384(89)90238-2 |
| format | Article |
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Estradiol (10, 100 or 1,000 μ/kg) and progesterone (50, 1,000 or 10,000 μ/kg), subcutaneously injected daily 4 times before the test, restored the duration of immobility in ovariectomized mice to normal, while having no effect on sham-operated animals. On the other hand, desipramine (20 mg/kg IP 1 hr before testing) significantly reduced the duration of immobility both in ovariectomized and in sham-operated mice. These data indicate that ovarian sex hormones, while having no “antidepressant,” desipramine-like, effect on the behavior of intact adult female mice, have such an effect in ovariectomized mice, and enable the animal to cope in a “normal” way with adverse environmental situations.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(89)90238-2</identifier><identifier>PMID: 2780868</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Animals ; Behavior, Animal - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Depression ; Depression - drug therapy ; Desipramine - pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Estradiol ; Estradiol - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Mice ; Miscellaneous ; Mouse ; Ovariectomy ; Progesterone ; Progesterone - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Tail suspension test</subject><ispartof>Physiology & behavior, 1989-05, Vol.45 (5), p.1067-1068</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-e1033f3d7ea159a75979026d54783ad8798f6a65773620393a055c0c1011c56c3</citedby><cites>FETCH-LOGICAL-c452t-e1033f3d7ea159a75979026d54783ad8798f6a65773620393a055c0c1011c56c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0031-9384(89)90238-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6768744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2780868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bernardi, M.</creatorcontrib><creatorcontrib>Vergoni, A.V.</creatorcontrib><creatorcontrib>Sandrini, M.</creatorcontrib><creatorcontrib>Tagliavini, S.</creatorcontrib><creatorcontrib>Bertolini, A.</creatorcontrib><title>Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>In the tail suspension test (an animal model of depression) the duration of immobility during the 6 min of observation was 56.84±6.54 sec in sham-ovariectomized mice and 113.11±7.86 sec 30–32 days after ovariectomy. Estradiol (10, 100 or 1,000 μ/kg) and progesterone (50, 1,000 or 10,000 μ/kg), subcutaneously injected daily 4 times before the test, restored the duration of immobility in ovariectomized mice to normal, while having no effect on sham-operated animals. On the other hand, desipramine (20 mg/kg IP 1 hr before testing) significantly reduced the duration of immobility both in ovariectomized and in sham-operated mice. These data indicate that ovarian sex hormones, while having no “antidepressant,” desipramine-like, effect on the behavior of intact adult female mice, have such an effect in ovariectomized mice, and enable the animal to cope in a “normal” way with adverse environmental situations.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Depression - drug therapy</subject><subject>Desipramine - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Estradiol</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mice</subject><subject>Miscellaneous</subject><subject>Mouse</subject><subject>Ovariectomy</subject><subject>Progesterone</subject><subject>Progesterone - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Tail suspension test</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo6-zqP1DIQUTB1qTT-bosyLLqwoIXBW8hm1S7ke5kTHoG999b7QxzNJdA6qnKmyeEvODsPWdcfWBM8M4KM7wx9q1lvTBd_4hsuNGik0z_eEw2J-QpOW_tF8MlBnFGznptmFFmQ9pNHqcd5AC0jLTsfU0QljI_vKPQlupjKhP1OdJtLT_xBGrJiGa63AO9g3u_T6WurXPCESkjS-HPFmqaIS9-onOJMK1AhG2F1lLJz8iT0U8Nnh_3C_L90_W3qy_d7dfPN1cfb7swyH7pgDMhRhE1eC6t19JqfKWKctBG-Gi0NaPySmotVM-EFZ5JGVhAOTxIFcQFeX2Yi9l_7zC8m1MLME0-Q9k1p23PuVYGweEAhlpaqzC6Leb39cFx5lbXbhXpVpHOWPfPteux7eVx_u5uhnhqOsrF-qtj3bfgp7H6HFI7YQqv1sOA2OUBA3SxT1BdC2n9kZgq_oWLJf0_x19VR5qn</recordid><startdate>19890501</startdate><enddate>19890501</enddate><creator>Bernardi, M.</creator><creator>Vergoni, A.V.</creator><creator>Sandrini, M.</creator><creator>Tagliavini, S.</creator><creator>Bertolini, A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890501</creationdate><title>Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression</title><author>Bernardi, M. ; Vergoni, A.V. ; Sandrini, M. ; Tagliavini, S. ; Bertolini, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-e1033f3d7ea159a75979026d54783ad8798f6a65773620393a055c0c1011c56c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Depression - drug therapy</topic><topic>Desipramine - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Estradiol</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Mice</topic><topic>Miscellaneous</topic><topic>Mouse</topic><topic>Ovariectomy</topic><topic>Progesterone</topic><topic>Progesterone - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Tail suspension test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernardi, M.</creatorcontrib><creatorcontrib>Vergoni, A.V.</creatorcontrib><creatorcontrib>Sandrini, M.</creatorcontrib><creatorcontrib>Tagliavini, S.</creatorcontrib><creatorcontrib>Bertolini, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernardi, M.</au><au>Vergoni, A.V.</au><au>Sandrini, M.</au><au>Tagliavini, S.</au><au>Bertolini, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1989-05-01</date><risdate>1989</risdate><volume>45</volume><issue>5</issue><spage>1067</spage><epage>1068</epage><pages>1067-1068</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>In the tail suspension test (an animal model of depression) the duration of immobility during the 6 min of observation was 56.84±6.54 sec in sham-ovariectomized mice and 113.11±7.86 sec 30–32 days after ovariectomy. Estradiol (10, 100 or 1,000 μ/kg) and progesterone (50, 1,000 or 10,000 μ/kg), subcutaneously injected daily 4 times before the test, restored the duration of immobility in ovariectomized mice to normal, while having no effect on sham-operated animals. On the other hand, desipramine (20 mg/kg IP 1 hr before testing) significantly reduced the duration of immobility both in ovariectomized and in sham-operated mice. These data indicate that ovarian sex hormones, while having no “antidepressant,” desipramine-like, effect on the behavior of intact adult female mice, have such an effect in ovariectomized mice, and enable the animal to cope in a “normal” way with adverse environmental situations.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2780868</pmid><doi>10.1016/0031-9384(89)90238-2</doi><tpages>2</tpages></addata></record> |
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| subjects | Animals Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Depression Depression - drug therapy Desipramine - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Estradiol Estradiol - pharmacology Female Fundamental and applied biological sciences. Psychology Mice Miscellaneous Mouse Ovariectomy Progesterone Progesterone - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Tail suspension test |
| title | Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression |
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