Modulation of the spinal network for locomotion by substance P in the neonatal rat
The tachykinin substance P (SP) is present in the ventral and medial area of the lumbar spinal cord. Its localisation suggests that it could modulate the spinal network for locomotion. We have investigated its effects on motor outputs by applying SP, in vitro, to the lumbosacral segments of an isola...
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| Veröffentlicht in: | Experimental brain research 1997-07, Vol.115 (3), p.485-492 |
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| creator | BARTHE, J.-Y CLARAC, F |
| description | The tachykinin substance P (SP) is present in the ventral and medial area of the lumbar spinal cord. Its localisation suggests that it could modulate the spinal network for locomotion. We have investigated its effects on motor outputs by applying SP, in vitro, to the lumbosacral segments of an isolated spinal cord of new-born rats. SP was applied to the lumbosacral spinal cord either on a quiescent preparation or during episodes of fictive locomotion induced by N-methyl-D,L-aspartate. When applied on quiescent preparations, SP induced a slow rhythmic activity (period >30 s). During fictive locomotion, SP increased both the locomotor frequency and the duration of the bursts of cyclic activity. Furthermore, SP stabilised the locomotor rhythm. These results demonstrate that SP is able to modulate both the "clock" and the pattern generator for locomotion. |
| doi_str_mv | 10.1007/pl00005718 |
| format | Article |
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Its localisation suggests that it could modulate the spinal network for locomotion. We have investigated its effects on motor outputs by applying SP, in vitro, to the lumbosacral segments of an isolated spinal cord of new-born rats. SP was applied to the lumbosacral spinal cord either on a quiescent preparation or during episodes of fictive locomotion induced by N-methyl-D,L-aspartate. When applied on quiescent preparations, SP induced a slow rhythmic activity (period >30 s). During fictive locomotion, SP increased both the locomotor frequency and the duration of the bursts of cyclic activity. Furthermore, SP stabilised the locomotor rhythm. These results demonstrate that SP is able to modulate both the "clock" and the pattern generator for locomotion.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/pl00005718</identifier><identifier>PMID: 9262203</identifier><identifier>CODEN: EXBRAP</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Locomotion - physiology ; Lumbosacral Region ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Nerve Net - physiology ; Periodicity ; Rats ; Rats, Wistar ; Spinal Cord - physiology ; Substance P - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Experimental brain research, 1997-07, Vol.115 (3), p.485-492</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-e006f59fb833e3c84fe8c5137bd555ac12dad7aa0f28f77f748232ad88264d213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2811129$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9262203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BARTHE, J.-Y</creatorcontrib><creatorcontrib>CLARAC, F</creatorcontrib><title>Modulation of the spinal network for locomotion by substance P in the neonatal rat</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>The tachykinin substance P (SP) is present in the ventral and medial area of the lumbar spinal cord. Its localisation suggests that it could modulate the spinal network for locomotion. We have investigated its effects on motor outputs by applying SP, in vitro, to the lumbosacral segments of an isolated spinal cord of new-born rats. SP was applied to the lumbosacral spinal cord either on a quiescent preparation or during episodes of fictive locomotion induced by N-methyl-D,L-aspartate. When applied on quiescent preparations, SP induced a slow rhythmic activity (period >30 s). During fictive locomotion, SP increased both the locomotor frequency and the duration of the bursts of cyclic activity. Furthermore, SP stabilised the locomotor rhythm. These results demonstrate that SP is able to modulate both the "clock" and the pattern generator for locomotion.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Locomotion - physiology</subject><subject>Lumbosacral Region</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Nerve Net - physiology</subject><subject>Periodicity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spinal Cord - physiology</subject><subject>Substance P - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67p68S7kIB6EaiZJm_Qoi1-w4iJ6LmmaYLVt1iRF9t_bXetencswvM8Mw4PQKZArIERcrxoyVCpA7qEpcEYTAJLtoykhwBMuIT9ERyF8bEYmyARNcppRStgUvTy5qm9UrF2HncXx3eCwqjvV4M7Eb-c_sXUeN0671m2hco1DX4aoOm3wEtfddqczrlNx2PIqHqMDq5pgTsY-Q293t6_zh2TxfP84v1kkmvM8JoaQzKa5LSVjhmnJrZE6BSbKKk1TpYFWqhJKEUulFcIKLimjqpKSZryiwGbo4vfuyruv3oRYtHXQpmnU8E0fCpHTwULO_wUhYwSEJAN4-Qtq70LwxhYrX7fKrwsgxcZ0sVz8mR7gs_FqX7am2qGj2iE_H3MVtGqsH4zVYYdRCQA0Zz-JSYR-</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>BARTHE, J.-Y</creator><creator>CLARAC, F</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>Modulation of the spinal network for locomotion by substance P in the neonatal rat</title><author>BARTHE, J.-Y ; CLARAC, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-e006f59fb833e3c84fe8c5137bd555ac12dad7aa0f28f77f748232ad88264d213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Locomotion - physiology</topic><topic>Lumbosacral Region</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Nerve Net - physiology</topic><topic>Periodicity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spinal Cord - physiology</topic><topic>Substance P - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BARTHE, J.-Y</creatorcontrib><creatorcontrib>CLARAC, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BARTHE, J.-Y</au><au>CLARAC, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of the spinal network for locomotion by substance P in the neonatal rat</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>115</volume><issue>3</issue><spage>485</spage><epage>492</epage><pages>485-492</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>The tachykinin substance P (SP) is present in the ventral and medial area of the lumbar spinal cord. Its localisation suggests that it could modulate the spinal network for locomotion. We have investigated its effects on motor outputs by applying SP, in vitro, to the lumbosacral segments of an isolated spinal cord of new-born rats. SP was applied to the lumbosacral spinal cord either on a quiescent preparation or during episodes of fictive locomotion induced by N-methyl-D,L-aspartate. When applied on quiescent preparations, SP induced a slow rhythmic activity (period >30 s). During fictive locomotion, SP increased both the locomotor frequency and the duration of the bursts of cyclic activity. Furthermore, SP stabilised the locomotor rhythm. These results demonstrate that SP is able to modulate both the "clock" and the pattern generator for locomotion.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9262203</pmid><doi>10.1007/pl00005718</doi><tpages>8</tpages></addata></record> |
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| ispartof | Experimental brain research, 1997-07, Vol.115 (3), p.485-492 |
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| subjects | Animals Animals, Newborn Biological and medical sciences Fundamental and applied biological sciences. Psychology Locomotion - physiology Lumbosacral Region Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Nerve Net - physiology Periodicity Rats Rats, Wistar Spinal Cord - physiology Substance P - physiology Vertebrates: nervous system and sense organs |
| title | Modulation of the spinal network for locomotion by substance P in the neonatal rat |
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