Insulin-Dependent Diabetes Mellitus (IDDM) Is Associated with CTLA4 Polymorphisms in Multiple Ethnic Groups
Linkage disequilibrium (association) analysis was used to evaluate a candidate region near the CTLA4/CD28 genes using a multi-ethnic collection of families with one or more children affected by IDDM. In the data set unique to this study (Spanish, French, Mexican-American, Chinese and Korean), the tr...
Gespeichert in:
| Veröffentlicht in: | Human molecular genetics 1997-08, Vol.6 (8), p.1275-1282 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1282 |
|---|---|
| container_issue | 8 |
| container_start_page | 1275 |
| container_title | Human molecular genetics |
| container_volume | 6 |
| creator | Marron, Michele P. Raffel, Leslie J. Garchon, Henri-Jean Jacob, Chaim O. Serrano-Rios, Manuel Martinez Larrad, Maria T. Teng, Wei-Ping Park, Yongsoo Zhang, Zhi-Xing Goldstein, Darlene R. Tao, Yi-Wen Beaurain, Genevieve Bach, Jean-Francois Huang, Hong-So Luo, De-Fang Zeidler, Adina Rotter, Jerome I. Yang, Mark C. K. Modilevsky, Tamara Maclaren, Noel K. She, Jin-Xiong |
| description | Linkage disequilibrium (association) analysis was used to evaluate a candidate region near the CTLA4/CD28 genes using a multi-ethnic collection of families with one or more children affected by IDDM. In the data set unique to this study (Spanish, French, Mexican-American, Chinese and Korean), the transmission/ disequilibrium test (TDT) revealed a highly significant deviation for transmission of alleles at the (AT)n microsatellite marker in the 3′ untranslated region (P = 0.002) and the A/G polymorphism in the first exon (P = 0.00002) of the CTLA4 gene. The overall evidence for transmission deviation of the CTLA4 A/G alleles is also highly significant (P= 0.00005) in the combined data set (669 multiplex and 357 simplex families) from this study and a previous report on families from USA, Italy, UK, Spain and Sardinia. Significant heterogeneity was observed in these data sets. The British, Sardinian and Chinese data sets did not show any deviation for the A/G polymorphism, while the Caucasian-American data set showed a weak transmission deviation. Strong deviation for transmission was seen in the three Mediterranean-European populations (Italian, Spanish and French) (P = 10−5), the Mexican-American population (P-0.002) and the Korean population (P = 0.03). These results suggest that a true IDDM susceptibility locus (designated IDDM12) is located near CTLA4. |
| doi_str_mv | 10.1093/hmg/6.8.1275 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79209266</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79209266</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-e7ea26369fdaa5e9324c9c7693d0a2b614b0a5dfc424b1d100df088d19721c403</originalsourceid><addsrcrecordid>eNqFkc1vEzEUxC0EKqFw44rkA6pAYlN_rb0-RknbRCSih4IQF8tre4npfrHPK9r_ni2JcuX0DvPTjOYNQm8pmVOi-eW--Xkp58WcMpU_QzMqJMkYKfhzNCNaikxqIl-iVwC_CKFScHWGzjTLNVN8hu43LYx1bLNV6EPrQ5vwKtoypAB4F-o6phHwh81qtfuIN4AXAJ2LNgWP_8S0x8u77ULg265-bLqh30doAMcW78Y6xb4O-Crt2-jwzdCNPbxGLypbQ3hzvOfo6_XV3XKdbb_cbJaLbeYEYykLKlgmudSVtzYPmjPhtFNSc08sKyUVJbG5ryZalNRTQnxFisJTrRh1gvBzdHHw7Yfu9xggmSaCm8rYNnQjGKUZ0UzK_4JU8lxOeRP46QC6oQMYQmX6ITZ2eDSUmKcRzDSCkaYwTyNM-Luj71g2wZ_g49cn_f1Rt-BsXQ22dRFO2GSh-L_U7IBFSOHhJNvh3kjFVW7W33-Y5VbQz99u1ybnfwHt1J2U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16356614</pqid></control><display><type>article</type><title>Insulin-Dependent Diabetes Mellitus (IDDM) Is Associated with CTLA4 Polymorphisms in Multiple Ethnic Groups</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Marron, Michele P. ; Raffel, Leslie J. ; Garchon, Henri-Jean ; Jacob, Chaim O. ; Serrano-Rios, Manuel ; Martinez Larrad, Maria T. ; Teng, Wei-Ping ; Park, Yongsoo ; Zhang, Zhi-Xing ; Goldstein, Darlene R. ; Tao, Yi-Wen ; Beaurain, Genevieve ; Bach, Jean-Francois ; Huang, Hong-So ; Luo, De-Fang ; Zeidler, Adina ; Rotter, Jerome I. ; Yang, Mark C. K. ; Modilevsky, Tamara ; Maclaren, Noel K. ; She, Jin-Xiong</creator><creatorcontrib>Marron, Michele P. ; Raffel, Leslie J. ; Garchon, Henri-Jean ; Jacob, Chaim O. ; Serrano-Rios, Manuel ; Martinez Larrad, Maria T. ; Teng, Wei-Ping ; Park, Yongsoo ; Zhang, Zhi-Xing ; Goldstein, Darlene R. ; Tao, Yi-Wen ; Beaurain, Genevieve ; Bach, Jean-Francois ; Huang, Hong-So ; Luo, De-Fang ; Zeidler, Adina ; Rotter, Jerome I. ; Yang, Mark C. K. ; Modilevsky, Tamara ; Maclaren, Noel K. ; She, Jin-Xiong</creatorcontrib><description>Linkage disequilibrium (association) analysis was used to evaluate a candidate region near the CTLA4/CD28 genes using a multi-ethnic collection of families with one or more children affected by IDDM. In the data set unique to this study (Spanish, French, Mexican-American, Chinese and Korean), the transmission/ disequilibrium test (TDT) revealed a highly significant deviation for transmission of alleles at the (AT)n microsatellite marker in the 3′ untranslated region (P = 0.002) and the A/G polymorphism in the first exon (P = 0.00002) of the CTLA4 gene. The overall evidence for transmission deviation of the CTLA4 A/G alleles is also highly significant (P= 0.00005) in the combined data set (669 multiplex and 357 simplex families) from this study and a previous report on families from USA, Italy, UK, Spain and Sardinia. Significant heterogeneity was observed in these data sets. The British, Sardinian and Chinese data sets did not show any deviation for the A/G polymorphism, while the Caucasian-American data set showed a weak transmission deviation. Strong deviation for transmission was seen in the three Mediterranean-European populations (Italian, Spanish and French) (P = 10−5), the Mexican-American population (P-0.002) and the Korean population (P = 0.03). These results suggest that a true IDDM susceptibility locus (designated IDDM12) is located near CTLA4.</description><identifier>ISSN: 0964-6906</identifier><identifier>ISSN: 1460-2083</identifier><identifier>EISSN: 1460-2083</identifier><identifier>DOI: 10.1093/hmg/6.8.1275</identifier><identifier>PMID: 9259273</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Abatacept ; Alleles ; Antigens, CD ; Antigens, Differentiation - genetics ; Biological and medical sciences ; Case-Control Studies ; CTLA-4 Antigen ; Diabetes Mellitus, Type 1 - ethnology ; Diabetes Mellitus, Type 1 - genetics ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Ethnic Groups - genetics ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Humans ; Immunoconjugates ; Linkage Disequilibrium ; Medical sciences ; Microsatellite Repeats ; Polymorphism, Genetic</subject><ispartof>Human molecular genetics, 1997-08, Vol.6 (8), p.1275-1282</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-e7ea26369fdaa5e9324c9c7693d0a2b614b0a5dfc424b1d100df088d19721c403</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2757314$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9259273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marron, Michele P.</creatorcontrib><creatorcontrib>Raffel, Leslie J.</creatorcontrib><creatorcontrib>Garchon, Henri-Jean</creatorcontrib><creatorcontrib>Jacob, Chaim O.</creatorcontrib><creatorcontrib>Serrano-Rios, Manuel</creatorcontrib><creatorcontrib>Martinez Larrad, Maria T.</creatorcontrib><creatorcontrib>Teng, Wei-Ping</creatorcontrib><creatorcontrib>Park, Yongsoo</creatorcontrib><creatorcontrib>Zhang, Zhi-Xing</creatorcontrib><creatorcontrib>Goldstein, Darlene R.</creatorcontrib><creatorcontrib>Tao, Yi-Wen</creatorcontrib><creatorcontrib>Beaurain, Genevieve</creatorcontrib><creatorcontrib>Bach, Jean-Francois</creatorcontrib><creatorcontrib>Huang, Hong-So</creatorcontrib><creatorcontrib>Luo, De-Fang</creatorcontrib><creatorcontrib>Zeidler, Adina</creatorcontrib><creatorcontrib>Rotter, Jerome I.</creatorcontrib><creatorcontrib>Yang, Mark C. K.</creatorcontrib><creatorcontrib>Modilevsky, Tamara</creatorcontrib><creatorcontrib>Maclaren, Noel K.</creatorcontrib><creatorcontrib>She, Jin-Xiong</creatorcontrib><title>Insulin-Dependent Diabetes Mellitus (IDDM) Is Associated with CTLA4 Polymorphisms in Multiple Ethnic Groups</title><title>Human molecular genetics</title><addtitle>Human Molecular Genetics</addtitle><description>Linkage disequilibrium (association) analysis was used to evaluate a candidate region near the CTLA4/CD28 genes using a multi-ethnic collection of families with one or more children affected by IDDM. In the data set unique to this study (Spanish, French, Mexican-American, Chinese and Korean), the transmission/ disequilibrium test (TDT) revealed a highly significant deviation for transmission of alleles at the (AT)n microsatellite marker in the 3′ untranslated region (P = 0.002) and the A/G polymorphism in the first exon (P = 0.00002) of the CTLA4 gene. The overall evidence for transmission deviation of the CTLA4 A/G alleles is also highly significant (P= 0.00005) in the combined data set (669 multiplex and 357 simplex families) from this study and a previous report on families from USA, Italy, UK, Spain and Sardinia. Significant heterogeneity was observed in these data sets. The British, Sardinian and Chinese data sets did not show any deviation for the A/G polymorphism, while the Caucasian-American data set showed a weak transmission deviation. Strong deviation for transmission was seen in the three Mediterranean-European populations (Italian, Spanish and French) (P = 10−5), the Mexican-American population (P-0.002) and the Korean population (P = 0.03). These results suggest that a true IDDM susceptibility locus (designated IDDM12) is located near CTLA4.</description><subject>Abatacept</subject><subject>Alleles</subject><subject>Antigens, CD</subject><subject>Antigens, Differentiation - genetics</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>CTLA-4 Antigen</subject><subject>Diabetes Mellitus, Type 1 - ethnology</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Ethnic Groups - genetics</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Humans</subject><subject>Immunoconjugates</subject><subject>Linkage Disequilibrium</subject><subject>Medical sciences</subject><subject>Microsatellite Repeats</subject><subject>Polymorphism, Genetic</subject><issn>0964-6906</issn><issn>1460-2083</issn><issn>1460-2083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEUxC0EKqFw44rkA6pAYlN_rb0-RknbRCSih4IQF8tre4npfrHPK9r_ni2JcuX0DvPTjOYNQm8pmVOi-eW--Xkp58WcMpU_QzMqJMkYKfhzNCNaikxqIl-iVwC_CKFScHWGzjTLNVN8hu43LYx1bLNV6EPrQ5vwKtoypAB4F-o6phHwh81qtfuIN4AXAJ2LNgWP_8S0x8u77ULg265-bLqh30doAMcW78Y6xb4O-Crt2-jwzdCNPbxGLypbQ3hzvOfo6_XV3XKdbb_cbJaLbeYEYykLKlgmudSVtzYPmjPhtFNSc08sKyUVJbG5ryZalNRTQnxFisJTrRh1gvBzdHHw7Yfu9xggmSaCm8rYNnQjGKUZ0UzK_4JU8lxOeRP46QC6oQMYQmX6ITZ2eDSUmKcRzDSCkaYwTyNM-Luj71g2wZ_g49cn_f1Rt-BsXQ22dRFO2GSh-L_U7IBFSOHhJNvh3kjFVW7W33-Y5VbQz99u1ybnfwHt1J2U</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Marron, Michele P.</creator><creator>Raffel, Leslie J.</creator><creator>Garchon, Henri-Jean</creator><creator>Jacob, Chaim O.</creator><creator>Serrano-Rios, Manuel</creator><creator>Martinez Larrad, Maria T.</creator><creator>Teng, Wei-Ping</creator><creator>Park, Yongsoo</creator><creator>Zhang, Zhi-Xing</creator><creator>Goldstein, Darlene R.</creator><creator>Tao, Yi-Wen</creator><creator>Beaurain, Genevieve</creator><creator>Bach, Jean-Francois</creator><creator>Huang, Hong-So</creator><creator>Luo, De-Fang</creator><creator>Zeidler, Adina</creator><creator>Rotter, Jerome I.</creator><creator>Yang, Mark C. K.</creator><creator>Modilevsky, Tamara</creator><creator>Maclaren, Noel K.</creator><creator>She, Jin-Xiong</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Insulin-Dependent Diabetes Mellitus (IDDM) Is Associated with CTLA4 Polymorphisms in Multiple Ethnic Groups</title><author>Marron, Michele P. ; Raffel, Leslie J. ; Garchon, Henri-Jean ; Jacob, Chaim O. ; Serrano-Rios, Manuel ; Martinez Larrad, Maria T. ; Teng, Wei-Ping ; Park, Yongsoo ; Zhang, Zhi-Xing ; Goldstein, Darlene R. ; Tao, Yi-Wen ; Beaurain, Genevieve ; Bach, Jean-Francois ; Huang, Hong-So ; Luo, De-Fang ; Zeidler, Adina ; Rotter, Jerome I. ; Yang, Mark C. K. ; Modilevsky, Tamara ; Maclaren, Noel K. ; She, Jin-Xiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-e7ea26369fdaa5e9324c9c7693d0a2b614b0a5dfc424b1d100df088d19721c403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Abatacept</topic><topic>Alleles</topic><topic>Antigens, CD</topic><topic>Antigens, Differentiation - genetics</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>CTLA-4 Antigen</topic><topic>Diabetes Mellitus, Type 1 - ethnology</topic><topic>Diabetes Mellitus, Type 1 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Ethnic Groups - genetics</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Humans</topic><topic>Immunoconjugates</topic><topic>Linkage Disequilibrium</topic><topic>Medical sciences</topic><topic>Microsatellite Repeats</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marron, Michele P.</creatorcontrib><creatorcontrib>Raffel, Leslie J.</creatorcontrib><creatorcontrib>Garchon, Henri-Jean</creatorcontrib><creatorcontrib>Jacob, Chaim O.</creatorcontrib><creatorcontrib>Serrano-Rios, Manuel</creatorcontrib><creatorcontrib>Martinez Larrad, Maria T.</creatorcontrib><creatorcontrib>Teng, Wei-Ping</creatorcontrib><creatorcontrib>Park, Yongsoo</creatorcontrib><creatorcontrib>Zhang, Zhi-Xing</creatorcontrib><creatorcontrib>Goldstein, Darlene R.</creatorcontrib><creatorcontrib>Tao, Yi-Wen</creatorcontrib><creatorcontrib>Beaurain, Genevieve</creatorcontrib><creatorcontrib>Bach, Jean-Francois</creatorcontrib><creatorcontrib>Huang, Hong-So</creatorcontrib><creatorcontrib>Luo, De-Fang</creatorcontrib><creatorcontrib>Zeidler, Adina</creatorcontrib><creatorcontrib>Rotter, Jerome I.</creatorcontrib><creatorcontrib>Yang, Mark C. K.</creatorcontrib><creatorcontrib>Modilevsky, Tamara</creatorcontrib><creatorcontrib>Maclaren, Noel K.</creatorcontrib><creatorcontrib>She, Jin-Xiong</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human molecular genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marron, Michele P.</au><au>Raffel, Leslie J.</au><au>Garchon, Henri-Jean</au><au>Jacob, Chaim O.</au><au>Serrano-Rios, Manuel</au><au>Martinez Larrad, Maria T.</au><au>Teng, Wei-Ping</au><au>Park, Yongsoo</au><au>Zhang, Zhi-Xing</au><au>Goldstein, Darlene R.</au><au>Tao, Yi-Wen</au><au>Beaurain, Genevieve</au><au>Bach, Jean-Francois</au><au>Huang, Hong-So</au><au>Luo, De-Fang</au><au>Zeidler, Adina</au><au>Rotter, Jerome I.</au><au>Yang, Mark C. K.</au><au>Modilevsky, Tamara</au><au>Maclaren, Noel K.</au><au>She, Jin-Xiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-Dependent Diabetes Mellitus (IDDM) Is Associated with CTLA4 Polymorphisms in Multiple Ethnic Groups</atitle><jtitle>Human molecular genetics</jtitle><addtitle>Human Molecular Genetics</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>6</volume><issue>8</issue><spage>1275</spage><epage>1282</epage><pages>1275-1282</pages><issn>0964-6906</issn><issn>1460-2083</issn><eissn>1460-2083</eissn><abstract>Linkage disequilibrium (association) analysis was used to evaluate a candidate region near the CTLA4/CD28 genes using a multi-ethnic collection of families with one or more children affected by IDDM. In the data set unique to this study (Spanish, French, Mexican-American, Chinese and Korean), the transmission/ disequilibrium test (TDT) revealed a highly significant deviation for transmission of alleles at the (AT)n microsatellite marker in the 3′ untranslated region (P = 0.002) and the A/G polymorphism in the first exon (P = 0.00002) of the CTLA4 gene. The overall evidence for transmission deviation of the CTLA4 A/G alleles is also highly significant (P= 0.00005) in the combined data set (669 multiplex and 357 simplex families) from this study and a previous report on families from USA, Italy, UK, Spain and Sardinia. Significant heterogeneity was observed in these data sets. The British, Sardinian and Chinese data sets did not show any deviation for the A/G polymorphism, while the Caucasian-American data set showed a weak transmission deviation. Strong deviation for transmission was seen in the three Mediterranean-European populations (Italian, Spanish and French) (P = 10−5), the Mexican-American population (P-0.002) and the Korean population (P = 0.03). These results suggest that a true IDDM susceptibility locus (designated IDDM12) is located near CTLA4.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>9259273</pmid><doi>10.1093/hmg/6.8.1275</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0964-6906 |
| ispartof | Human molecular genetics, 1997-08, Vol.6 (8), p.1275-1282 |
| issn | 0964-6906 1460-2083 1460-2083 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79209266 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Abatacept Alleles Antigens, CD Antigens, Differentiation - genetics Biological and medical sciences Case-Control Studies CTLA-4 Antigen Diabetes Mellitus, Type 1 - ethnology Diabetes Mellitus, Type 1 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Ethnic Groups - genetics Etiopathogenesis. Screening. Investigations. Target tissue resistance Humans Immunoconjugates Linkage Disequilibrium Medical sciences Microsatellite Repeats Polymorphism, Genetic |
| title | Insulin-Dependent Diabetes Mellitus (IDDM) Is Associated with CTLA4 Polymorphisms in Multiple Ethnic Groups |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T14%3A48%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Insulin-Dependent%20Diabetes%20Mellitus%20(IDDM)%20Is%20Associated%20with%20CTLA4%20Polymorphisms%20in%20Multiple%20Ethnic%20Groups&rft.jtitle=Human%20molecular%20genetics&rft.au=Marron,%20Michele%20P.&rft.date=1997-08-01&rft.volume=6&rft.issue=8&rft.spage=1275&rft.epage=1282&rft.pages=1275-1282&rft.issn=0964-6906&rft.eissn=1460-2083&rft_id=info:doi/10.1093/hmg/6.8.1275&rft_dat=%3Cproquest_cross%3E79209266%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16356614&rft_id=info:pmid/9259273&rfr_iscdi=true |