HLA Antigens in Depressed, Demented, and Nondemented Elderly
To identify HLA antigen associations with geriatric depression, the authors typed 36 elderly patients with major depression and, for comparison, 36 patients with Alzheimer-type dementia and 29 nondemented elderly controls. The frequency for antigen Aw32 was significantly higher in the group of patie...
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| Veröffentlicht in: | Journal of geriatric psychiatry and neurology 1989-04, Vol.2 (2), p.70-75 |
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| container_title | Journal of geriatric psychiatry and neurology |
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| creator | Small, Gary W. Matsuyama, Steven S. Komanduri, Ramanujam Spar, James E. Fairbanks, Lynn |
| description | To identify HLA antigen associations with geriatric depression, the authors typed 36 elderly patients with major depression and, for comparison, 36 patients with Alzheimer-type dementia and 29 nondemented elderly controls. The frequency for antigen Aw32 was significantly higher in the group of patients with major depression (14%) than in the demented (0%) and control (3%) groups. The frequencies for antigens Aw32 (22%) and Bw51 (22%) were significantly higher in the subgroup of 23 patients with endogenous depression than in the demented (Aw32 = 0%; Bw51 = 11%) and the control (Aw32 = 3%; Bw51 = 0%) groups. Although these results were derived from a relatively small sample (n = 101) and become nonsignificant when corrected for multiple comparisons, they suggest that HLA antigen associations may be present for only certain depressive subtypes in geriatric depression. (J Geriatr Psychiatry Neurol 1989;2:70-75). |
| doi_str_mv | 10.1177/089198878900200203 |
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The frequency for antigen Aw32 was significantly higher in the group of patients with major depression (14%) than in the demented (0%) and control (3%) groups. The frequencies for antigens Aw32 (22%) and Bw51 (22%) were significantly higher in the subgroup of 23 patients with endogenous depression than in the demented (Aw32 = 0%; Bw51 = 11%) and the control (Aw32 = 3%; Bw51 = 0%) groups. Although these results were derived from a relatively small sample (n = 101) and become nonsignificant when corrected for multiple comparisons, they suggest that HLA antigen associations may be present for only certain depressive subtypes in geriatric depression. 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The frequency for antigen Aw32 was significantly higher in the group of patients with major depression (14%) than in the demented (0%) and control (3%) groups. The frequencies for antigens Aw32 (22%) and Bw51 (22%) were significantly higher in the subgroup of 23 patients with endogenous depression than in the demented (Aw32 = 0%; Bw51 = 11%) and the control (Aw32 = 3%; Bw51 = 0%) groups. Although these results were derived from a relatively small sample (n = 101) and become nonsignificant when corrected for multiple comparisons, they suggest that HLA antigen associations may be present for only certain depressive subtypes in geriatric depression. (J Geriatr Psychiatry Neurol 1989;2:70-75).</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - immunology</subject><subject>Dementia - immunology</subject><subject>Depressive Disorder - immunology</subject><subject>Female</subject><subject>HLA Antigens - analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Sex Factors</subject><issn>0891-9887</issn><issn>1552-5708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFLw0AQhRdRaq3-AUHIyZOxO7vZ7Cx4KbVaoehFz2FNpiUl2dTd9NB_b0KDF0FhYIZ533uHx9g18HsAraccDRhEjYZz0Y88YWNQSsRKczxl4x6Ie-KcXYSw5Zwrg3LERkJrlUgcs4flahbNXFtuyIWodNEj7TyFQMVdd9bk2v6yroheG1cMj2hRFeSrwyU7W9sq0NWwJ-zjafE-X8art-eX-WwV50KqNpYIWkCSQgq4VhalLgySzg1yY0wubC54whOlrbIkrJCUSGHyBLgEIFBywm6PuTvffO0ptFldhpyqyjpq9iHTRnBMjfgXFACIKaYdKI5g7psQPK2znS9r6w8Z8KzvNvvdbWe6GdL3nzUVP5ahzE6fHvVgN5Rtm713XSt_JX4DyXF9hA</recordid><startdate>198904</startdate><enddate>198904</enddate><creator>Small, Gary W.</creator><creator>Matsuyama, Steven S.</creator><creator>Komanduri, Ramanujam</creator><creator>Spar, James E.</creator><creator>Fairbanks, Lynn</creator><general>Sage Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198904</creationdate><title>HLA Antigens in Depressed, Demented, and Nondemented Elderly</title><author>Small, Gary W. ; Matsuyama, Steven S. ; Komanduri, Ramanujam ; Spar, James E. ; Fairbanks, Lynn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c235t-381721461618f5a837d98e7c980999c2ac2040457a5ae2a23e4329c410311e153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - immunology</topic><topic>Dementia - immunology</topic><topic>Depressive Disorder - immunology</topic><topic>Female</topic><topic>HLA Antigens - analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Small, Gary W.</creatorcontrib><creatorcontrib>Matsuyama, Steven S.</creatorcontrib><creatorcontrib>Komanduri, Ramanujam</creatorcontrib><creatorcontrib>Spar, James E.</creatorcontrib><creatorcontrib>Fairbanks, Lynn</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of geriatric psychiatry and neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Small, Gary W.</au><au>Matsuyama, Steven S.</au><au>Komanduri, Ramanujam</au><au>Spar, James E.</au><au>Fairbanks, Lynn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA Antigens in Depressed, Demented, and Nondemented Elderly</atitle><jtitle>Journal of geriatric psychiatry and neurology</jtitle><addtitle>J Geriatr Psychiatry Neurol</addtitle><date>1989-04</date><risdate>1989</risdate><volume>2</volume><issue>2</issue><spage>70</spage><epage>75</epage><pages>70-75</pages><issn>0891-9887</issn><eissn>1552-5708</eissn><abstract>To identify HLA antigen associations with geriatric depression, the authors typed 36 elderly patients with major depression and, for comparison, 36 patients with Alzheimer-type dementia and 29 nondemented elderly controls. 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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Age Factors Aged Aged, 80 and over Alzheimer Disease - immunology Dementia - immunology Depressive Disorder - immunology Female HLA Antigens - analysis Humans Male Middle Aged Reference Values Sex Factors |
| title | HLA Antigens in Depressed, Demented, and Nondemented Elderly |
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