Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer
Hormonal breast cancer therapies have traditionally been considered cytostatic, but recent pre‐clinical data suggest that anti‐oestrogens can induce apoptosis. The aim of this study was to assess whether tamoxifen (TAM) and ICI 182780 (ICI) could induce apoptosis in human breast cancer, and whether...
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| Veröffentlicht in: | International journal of cancer 1997-08, Vol.72 (4), p.608-613 |
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| container_title | International journal of cancer |
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| creator | Ellis, Paul A. Saccani‐Jotti, Gloria Clarke, Robert Johnston, Stephen R.D. Anderson, Elizabeth Howell, Anthony A'hern, Roger Salter, Janine Detre, Simone Nicholson, Robert Robertson, John Smith, Ian E. Dowsett, Mitchell |
| description | Hormonal breast cancer therapies have traditionally been considered cytostatic, but recent pre‐clinical data suggest that anti‐oestrogens can induce apoptosis. The aim of this study was to assess whether tamoxifen (TAM) and ICI 182780 (ICI) could induce apoptosis in human breast cancer, and whether this was related to oestrogen receptor status. We measured apoptosis in primary breast cancer patients before and after pre‐surgical treatment with 20 mg/day TAM (study 1) or 6 or 18 mg/day ICI (study 2). In each study there was a randomised non‐treatment (NT) control group. TAM significantly increased apoptotic index (AI) in ER+ but not in ER− tumours. There was a significant increase in AI following treatment with ICI. Insufficient pairs of samples were available to determine whether this change was confined to ER+ tumours, but in a cross‐sectional analysis AI was significantly higher in excision biopsies for ICI‐treated than NT patients for ER+ but not ER− tumours. Our results provide clinical evidence that apoptosis may be induced in ER+ primary breast cancer by both non‐steroidal and steroidal anti‐oestrogens. Int. J. Cancer 72:608–613, 1997. © 1997 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0215(19970807)72:4<608::AID-IJC10>3.0.CO;2-7 |
| format | Article |
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The aim of this study was to assess whether tamoxifen (TAM) and ICI 182780 (ICI) could induce apoptosis in human breast cancer, and whether this was related to oestrogen receptor status. We measured apoptosis in primary breast cancer patients before and after pre‐surgical treatment with 20 mg/day TAM (study 1) or 6 or 18 mg/day ICI (study 2). In each study there was a randomised non‐treatment (NT) control group. TAM significantly increased apoptotic index (AI) in ER+ but not in ER− tumours. There was a significant increase in AI following treatment with ICI. Insufficient pairs of samples were available to determine whether this change was confined to ER+ tumours, but in a cross‐sectional analysis AI was significantly higher in excision biopsies for ICI‐treated than NT patients for ER+ but not ER− tumours. Our results provide clinical evidence that apoptosis may be induced in ER+ primary breast cancer by both non‐steroidal and steroidal anti‐oestrogens. Int. J. Cancer 72:608–613, 1997. © 1997 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/(SICI)1097-0215(19970807)72:4<608::AID-IJC10>3.0.CO;2-7</identifier><identifier>PMID: 9259399</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antineoplastic agents ; Antineoplastic Agents - therapeutic use ; Antineoplastic Agents, Hormonal - therapeutic use ; Apoptosis - drug effects ; Biological and medical sciences ; Biopsy ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Chemotherapy ; Combined Modality Therapy ; Estradiol - analogs & derivatives ; Estradiol - therapeutic use ; Estrogen Antagonists - therapeutic use ; Female ; Fulvestrant ; Humans ; Longitudinal Studies ; Medical sciences ; Middle Aged ; Paraffin Embedding ; Pharmacology. 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The aim of this study was to assess whether tamoxifen (TAM) and ICI 182780 (ICI) could induce apoptosis in human breast cancer, and whether this was related to oestrogen receptor status. We measured apoptosis in primary breast cancer patients before and after pre‐surgical treatment with 20 mg/day TAM (study 1) or 6 or 18 mg/day ICI (study 2). In each study there was a randomised non‐treatment (NT) control group. TAM significantly increased apoptotic index (AI) in ER+ but not in ER− tumours. There was a significant increase in AI following treatment with ICI. Insufficient pairs of samples were available to determine whether this change was confined to ER+ tumours, but in a cross‐sectional analysis AI was significantly higher in excision biopsies for ICI‐treated than NT patients for ER+ but not ER− tumours. Our results provide clinical evidence that apoptosis may be induced in ER+ primary breast cancer by both non‐steroidal and steroidal anti‐oestrogens. Int. J. Cancer 72:608–613, 1997. © 1997 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Chemotherapy</subject><subject>Combined Modality Therapy</subject><subject>Estradiol - analogs & derivatives</subject><subject>Estradiol - therapeutic use</subject><subject>Estrogen Antagonists - therapeutic use</subject><subject>Female</subject><subject>Fulvestrant</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Paraffin Embedding</subject><subject>Pharmacology. Drug treatments</subject><subject>Placebos</subject><subject>Receptors, Estrogen - analysis</subject><subject>Tamoxifen - therapeutic use</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2L1EAQhhtR1tnVnyD0QWT3kLG6Op1Oz4qyxK_owhxU9FZ0km6IZJIxnWGdf2-PE-ei4Kmg6q2Xh4exVwKWAgCfX34qi_JKgNEJoFCXwhgNOegrjav0RQb5anVTvk7KD4WAl3IJy2J9jYm-xxann_tsEZsg0UJmD9l5CN8BhFCQnrEzg8pIYxbsY9k3u3pqh54PntvtsJ2G0AZe7flkN8PP1rue277hEYeLHHUOvO35dmw3dtzzanQ2TLy2fe3GR-yBt11wj-d5wb68ffO5eJ_crt-Vxc1tUqdaQWLr1BjvK5tXVnjMJCpEWzeZycGCyoxTBiuhwWEqfdUYJaTzXufCGsxlKi_Ys2Pvdhx-7FyYaNOG2nWd7d2wC6QNgkatYvDrMViPQwij8zRzkwA6aCY6aKaDMjoooz-aSSOlFDUTRc30WzNJAirWhKRj85MZYVdtXHPqnb3G-9P5bkNtOz9GQW04xVBnOgMZY9-Osbu2c_u_6P4L9y-240L-AmJHom0</recordid><startdate>19970807</startdate><enddate>19970807</enddate><creator>Ellis, Paul A.</creator><creator>Saccani‐Jotti, Gloria</creator><creator>Clarke, Robert</creator><creator>Johnston, Stephen R.D.</creator><creator>Anderson, Elizabeth</creator><creator>Howell, Anthony</creator><creator>A'hern, Roger</creator><creator>Salter, Janine</creator><creator>Detre, Simone</creator><creator>Nicholson, Robert</creator><creator>Robertson, John</creator><creator>Smith, Ian E.</creator><creator>Dowsett, Mitchell</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970807</creationdate><title>Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer</title><author>Ellis, Paul A. ; Saccani‐Jotti, Gloria ; Clarke, Robert ; Johnston, Stephen R.D. ; Anderson, Elizabeth ; Howell, Anthony ; A'hern, Roger ; Salter, Janine ; Detre, Simone ; Nicholson, Robert ; Robertson, John ; Smith, Ian E. ; Dowsett, Mitchell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4750-ac499ffba8ba1f2632522acd6980a0569e592b170e243fbd9513eff781a928343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Chemotherapy</topic><topic>Combined Modality Therapy</topic><topic>Estradiol - analogs & derivatives</topic><topic>Estradiol - therapeutic use</topic><topic>Estrogen Antagonists - therapeutic use</topic><topic>Female</topic><topic>Fulvestrant</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Paraffin Embedding</topic><topic>Pharmacology. 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The aim of this study was to assess whether tamoxifen (TAM) and ICI 182780 (ICI) could induce apoptosis in human breast cancer, and whether this was related to oestrogen receptor status. We measured apoptosis in primary breast cancer patients before and after pre‐surgical treatment with 20 mg/day TAM (study 1) or 6 or 18 mg/day ICI (study 2). In each study there was a randomised non‐treatment (NT) control group. TAM significantly increased apoptotic index (AI) in ER+ but not in ER− tumours. There was a significant increase in AI following treatment with ICI. Insufficient pairs of samples were available to determine whether this change was confined to ER+ tumours, but in a cross‐sectional analysis AI was significantly higher in excision biopsies for ICI‐treated than NT patients for ER+ but not ER− tumours. Our results provide clinical evidence that apoptosis may be induced in ER+ primary breast cancer by both non‐steroidal and steroidal anti‐oestrogens. Int. J. 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| subjects | Adult Aged Aged, 80 and over Antineoplastic agents Antineoplastic Agents - therapeutic use Antineoplastic Agents, Hormonal - therapeutic use Apoptosis - drug effects Biological and medical sciences Biopsy Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - surgery Chemotherapy Combined Modality Therapy Estradiol - analogs & derivatives Estradiol - therapeutic use Estrogen Antagonists - therapeutic use Female Fulvestrant Humans Longitudinal Studies Medical sciences Middle Aged Paraffin Embedding Pharmacology. Drug treatments Placebos Receptors, Estrogen - analysis Tamoxifen - therapeutic use |
| title | Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer |
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