Evidence for increased lipid peroxidation in the non-ischaemic portion of the heart with coronary occlusion
Lipid peroxidation products, malondialdehyde (MDA), conjugated double bonds (CDB), and fluorescent end products (RF), were measured in porcine left ventricular myocardium. Myocardial samples were taken 15–20 min after left anterior descending coronary artery (LAD) ligation from ischaemic and non-isc...
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| Veröffentlicht in: | Cardiovascular research 1989-02, Vol.23 (2), p.98-103 |
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| container_title | Cardiovascular research |
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| creator | HERBACZYŃSKA-CEDRO, KRYSTYNA GORDON-MAJSZAK, WANDA |
| description | Lipid peroxidation products, malondialdehyde (MDA), conjugated double bonds (CDB), and fluorescent end products (RF), were measured in porcine left ventricular myocardium. Myocardial samples were taken 15–20 min after left anterior descending coronary artery (LAD) ligation from ischaemic and non-ischaemic regions. Products of lipid peroxidation were also measured in the left ventricular myocardium of sham operated pigs. Non-ischaemic regions of the hearts with LAD occlusion showed a significantly higher content of lipid peroxidation products than intact hearts of sham operated pigs. The results suggest that enhancement of lipid peroxidation reflecting increased free radical generation may contribute to myocardial damage in the non-ischaemic, apparently “healthy” portion of the heart with acute coronary occlusion. |
| doi_str_mv | 10.1093/cvr/23.2.98 |
| format | Article |
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Myocardial samples were taken 15–20 min after left anterior descending coronary artery (LAD) ligation from ischaemic and non-ischaemic regions. Products of lipid peroxidation were also measured in the left ventricular myocardium of sham operated pigs. Non-ischaemic regions of the hearts with LAD occlusion showed a significantly higher content of lipid peroxidation products than intact hearts of sham operated pigs. The results suggest that enhancement of lipid peroxidation reflecting increased free radical generation may contribute to myocardial damage in the non-ischaemic, apparently “healthy” portion of the heart with acute coronary occlusion.</description><identifier>ISSN: 0008-6363</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1093/cvr/23.2.98</identifier><identifier>PMID: 2776163</identifier><identifier>CODEN: CVREAU</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; Cardiology. 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Myocardial samples were taken 15–20 min after left anterior descending coronary artery (LAD) ligation from ischaemic and non-ischaemic regions. Products of lipid peroxidation were also measured in the left ventricular myocardium of sham operated pigs. Non-ischaemic regions of the hearts with LAD occlusion showed a significantly higher content of lipid peroxidation products than intact hearts of sham operated pigs. The results suggest that enhancement of lipid peroxidation reflecting increased free radical generation may contribute to myocardial damage in the non-ischaemic, apparently “healthy” portion of the heart with acute coronary occlusion.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - metabolism</subject><subject>Coronary heart disease</subject><subject>Fluorescence</subject><subject>Free Radicals</subject><subject>Heart</subject><subject>Lipid Peroxidation</subject><subject>Malondialdehyde - analysis</subject><subject>Medical sciences</subject><subject>myocardial ischaemia</subject><subject>Myocardium - metabolism</subject><subject>Swine</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kN9rFDEUhYNY6lp98lnIg_gis81NNj_mUbbVCoWKWCh9CZnMDRs7OxmT2Vr_e2N32afD5fs4XA4h74AtgbXi3D_mcy6WfNmaF2QBWspG8JV8SRaMMdMoocQr8rqUX_WUUq9OySnXWoESC_Jw-Rh7HD3SkDKNo8_oCvZ0iFPs6YQ5PcXezTGNFdJ5g3RMYxOL3zjcRk-nlJ9hCs9wgy7P9E-cN9SnnEaX_9Lk_bArVXpDToIbCr495Bm5_XL5c33VXN98_bb-fN14IdTchLaGAmMC17KXHJlj2gMY14GAgMrLToBmwUmQvvMBetODaDttWh2CEmfk4753yun3Dstst_VhHAY3YtoVq1vOlDZQxU970edUSsZgpxy39WcLzP6f1tZpLReW29ZU-_2hdtdtsT-6hy0r_3Dgrng3hOxGH8tR07BqV4JVrdlrscz4dMQuP1ilhZb26u7ewo_vEi7W2t6Jfzzwkck</recordid><startdate>198902</startdate><enddate>198902</enddate><creator>HERBACZYŃSKA-CEDRO, KRYSTYNA</creator><creator>GORDON-MAJSZAK, WANDA</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198902</creationdate><title>Evidence for increased lipid peroxidation in the non-ischaemic portion of the heart with coronary occlusion</title><author>HERBACZYŃSKA-CEDRO, KRYSTYNA ; GORDON-MAJSZAK, WANDA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-f93366188f275d52e0a07c118ab131fe6c5b3170fa515cbcf1d8d139b7897ff63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - metabolism</topic><topic>Coronary heart disease</topic><topic>Fluorescence</topic><topic>Free Radicals</topic><topic>Heart</topic><topic>Lipid Peroxidation</topic><topic>Malondialdehyde - analysis</topic><topic>Medical sciences</topic><topic>myocardial ischaemia</topic><topic>Myocardium - metabolism</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HERBACZYŃSKA-CEDRO, KRYSTYNA</creatorcontrib><creatorcontrib>GORDON-MAJSZAK, WANDA</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HERBACZYŃSKA-CEDRO, KRYSTYNA</au><au>GORDON-MAJSZAK, WANDA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for increased lipid peroxidation in the non-ischaemic portion of the heart with coronary occlusion</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>1989-02</date><risdate>1989</risdate><volume>23</volume><issue>2</issue><spage>98</spage><epage>103</epage><pages>98-103</pages><issn>0008-6363</issn><eissn>1755-3245</eissn><coden>CVREAU</coden><abstract>Lipid peroxidation products, malondialdehyde (MDA), conjugated double bonds (CDB), and fluorescent end products (RF), were measured in porcine left ventricular myocardium. Myocardial samples were taken 15–20 min after left anterior descending coronary artery (LAD) ligation from ischaemic and non-ischaemic regions. Products of lipid peroxidation were also measured in the left ventricular myocardium of sham operated pigs. Non-ischaemic regions of the hearts with LAD occlusion showed a significantly higher content of lipid peroxidation products than intact hearts of sham operated pigs. The results suggest that enhancement of lipid peroxidation reflecting increased free radical generation may contribute to myocardial damage in the non-ischaemic, apparently “healthy” portion of the heart with acute coronary occlusion.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>2776163</pmid><doi>10.1093/cvr/23.2.98</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-6363 |
| ispartof | Cardiovascular research, 1989-02, Vol.23 (2), p.98-103 |
| issn | 0008-6363 1755-3245 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Biological and medical sciences Cardiology. Vascular system Coronary Disease - metabolism Coronary heart disease Fluorescence Free Radicals Heart Lipid Peroxidation Malondialdehyde - analysis Medical sciences myocardial ischaemia Myocardium - metabolism Swine |
| title | Evidence for increased lipid peroxidation in the non-ischaemic portion of the heart with coronary occlusion |
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