A High Frequency African Coding Polymorphism in the N-Terminal Domain of ICAM-1 Predisposing to Cerebral Malaria in Kenya

The malarial parasite Plasmodium falciparum has acted as a potent selective force on the human genome. The particular virulence of this organism is thought to be due to the adherence of parasitised red blood cells to small vessel endothelium through several receptors, including CD36, thrombospondin...

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Veröffentlicht in:	Human molecular genetics 1997-08, Vol.6 (8), p.1357-1360
Hauptverfasser:	Fernandez-Reyes, D., Craig, A. G., Kyes, S. A., Peshu, N., Snow, R. W., Berendt, A. R., Marsh, K., Newbold, C. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	African Continental Ancestry Group - genetics Animals Biological and medical sciences Case-Control Studies Causality Child Child, Preschool Erythrocytes - metabolism Gene Frequency Human protozoal diseases Humans Infant Infectious diseases Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Kenya Malaria Malaria, Cerebral - genetics Medical sciences Parasitic diseases Plasmodium falciparum Polymorphism, Genetic Protozoal diseases
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