Regional Intestinal Permeability in Rats of Compounds with Different Physicochemical Properties and Transport Mechanisms

Because the absorption of orally administered drugs depends on intestinal permeability, we have investigated how absorptive capacity varies from the proximal to distal intestine in rats. The effective permeabilities of compounds with a range of physicochemical properties and different absorption mec...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 1997-07, Vol.49 (7), p.687-690
Hauptverfasser:	FAGERHOLM, URBAN, LINDAHL, ANDERS, LENNERNÄS, HANS
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Analysis of Variance Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - pharmacokinetics Antihypertensive Agents - administration & dosage Antihypertensive Agents - pharmacokinetics Antipyrine - administration & dosage Antipyrine - pharmacokinetics Atenolol - administration & dosage Atenolol - pharmacokinetics Biological and medical sciences Biological Transport Colon - metabolism Fatty Acids, Monounsaturated - administration & dosage Fatty Acids, Monounsaturated - pharmacokinetics Fluvastatin Fundamental and applied biological sciences. Psychology Glucose - administration & dosage Glucose - pharmacokinetics Hydrogen-Ion Concentration Ileum - metabolism Indoles - administration & dosage Indoles - pharmacokinetics Intestinal Absorption - physiology Intestine. Mesentery Jejunum - metabolism Levodopa - administration & dosage Levodopa - pharmacokinetics Membrane Fluidity - physiology Metoprolol - administration & dosage Metoprolol - pharmacokinetics Naproxen - administration & dosage Naproxen - pharmacokinetics Perfusion Permeability Rats Stereoisomerism Structure-Activity Relationship Vertebrates: digestive system
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