Phospholipase D in homogenates from HL-60 granulocytes: Implications of calcium and G protein control

Occupancy of chemotactic peptide receptors leads to rapid initiation of phospholipase D (PLD) activity in intact dimethylsulfoxide-differentiated HL-60 granulocytes (Pai, J.-K, Siegel, M.I., Egan, R.W., and Billah, M.M. (1988) J. Biol. Chem. 263 , 12472). To gain further insight into the activation...

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Veröffentlicht in:	Biochemical and biophysical research communications 1989-08, Vol.163 (1), p.657-664
Hauptverfasser:	Anthes, John C., Eckel, Stephen, Siegel, Marvin I., Egan, Robert W., Billah, M.Motasim
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences calcium Calcium - physiology Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Glycerophospholipids Granulocytes - physiology GTP-Binding Proteins - physiology guanine nucleotide-binding protein Guanosine 5'-O-(3-Thiotriphosphate) Guanosine Triphosphate - analogs & derivatives Guanosine Triphosphate - pharmacology Humans Hydrolases Phosphatidic Acids - metabolism Phosphatidylcholines - metabolism Phospholipase D - metabolism Phospholipases - metabolism rats Substrate Specificity Thionucleotides - pharmacology Tumor Cells, Cultured
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