High-Resolution NMR imaging of an antigen-induced arthritis in the Rabbit Knee
High‐resolution, serial, spin‐echo images were obtained for an antigen‐induced knee arthritis in six rabbits. The animals were imaged prior to intra‐articular challenge and at various time points up to 14 weeks after challenge. Extensive high‐signal inflammatory changes were seen at Day 1 in the lym...
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| Veröffentlicht in: | Magnetic resonance in medicine 1989-08, Vol.11 (2), p.221-235 |
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| creator | Checkley, David Johnstone, Donna Taylor, Kay Waterton, John C. |
| description | High‐resolution, serial, spin‐echo images were obtained for an antigen‐induced knee arthritis in six rabbits. The animals were imaged prior to intra‐articular challenge and at various time points up to 14 weeks after challenge. Extensive high‐signal inflammatory changes were seen at Day 1 in the lymph node, capsule, and surrounding muscle. The muscle and lymph node response decreased rapidly after the first week. The capsule high‐signal area reached a maximum at Day 10, but was still extensive at Day 39. The infrapatellar fat pad was replaced more slowly by high signal and the appearance of high signal in both the tibia and femur was a late change. Terminal histological examination showed that the capsule and fat pad high‐signal areas corresponded to fibrous and synovial proliferation. The bone changes were a result of edema and cyst formation. The separation of the various time courses of the inflammatory changes may be of value in understanding the model and evaluating potential anti‐arthritic drugs. © 1989 Academic Press, Inc. |
| doi_str_mv | 10.1002/mrm.1910110210 |
| format | Article |
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The animals were imaged prior to intra‐articular challenge and at various time points up to 14 weeks after challenge. Extensive high‐signal inflammatory changes were seen at Day 1 in the lymph node, capsule, and surrounding muscle. The muscle and lymph node response decreased rapidly after the first week. The capsule high‐signal area reached a maximum at Day 10, but was still extensive at Day 39. The infrapatellar fat pad was replaced more slowly by high signal and the appearance of high signal in both the tibia and femur was a late change. Terminal histological examination showed that the capsule and fat pad high‐signal areas corresponded to fibrous and synovial proliferation. The bone changes were a result of edema and cyst formation. 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Reson. Med</addtitle><description>High‐resolution, serial, spin‐echo images were obtained for an antigen‐induced knee arthritis in six rabbits. The animals were imaged prior to intra‐articular challenge and at various time points up to 14 weeks after challenge. Extensive high‐signal inflammatory changes were seen at Day 1 in the lymph node, capsule, and surrounding muscle. The muscle and lymph node response decreased rapidly after the first week. The capsule high‐signal area reached a maximum at Day 10, but was still extensive at Day 39. The infrapatellar fat pad was replaced more slowly by high signal and the appearance of high signal in both the tibia and femur was a late change. Terminal histological examination showed that the capsule and fat pad high‐signal areas corresponded to fibrous and synovial proliferation. The bone changes were a result of edema and cyst formation. The separation of the various time courses of the inflammatory changes may be of value in understanding the model and evaluating potential anti‐arthritic drugs. © 1989 Academic Press, Inc.</description><subject>Animals</subject><subject>Arthritis - pathology</subject><subject>Arthritis, Experimental - pathology</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - pathology</subject><subject>Diseases of the osteoarticular system</subject><subject>Inflammatory joint diseases</subject><subject>Knee</subject><subject>Lymph Nodes - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscles - pathology</subject><subject>Rabbits</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFvEzEQhS1EVULhyg3JB8RtU4_ttTtHVEGDaFIpKurR8nrtxLDrLfauoP-eRYmCOCGNNIf53puZR8gbYEtgjF_2uV8CAgNgHNgzsoCa84rXKJ-TBdOSVQJQviAvS_nGGEPU8pycc61RgliQzSru9tXWl6GbxjgkullvaeztLqYdHQK1aa4x7nyqYmon51tq87jPcYyFxkTHvadb2zRxpF-S96_IWbBd8a-P_YJ8_fTx_npV3d7dfL7-cFs5yTSrZI2tE8IHpxvBnbUKrxTypq6daJiqW668CFxdqaCdQ4QATDrVWAiyDajEBXl_8H3Mw4_Jl9H0sTjfdTb5YSpGIyAi0zO4PIAuD6VkH8xjnt_LTwaY-ROgmQM0fwOcBW-PzlPT-_aEHxOb5--Oc1uc7UK2ycVywpSWQnM-Y3jAfsbOP_1nqVlv1_-cUB20sYz-10lr8_fZXujaPGxuTP0AsMK1NFL8BoO5lvI</recordid><startdate>198908</startdate><enddate>198908</enddate><creator>Checkley, David</creator><creator>Johnstone, Donna</creator><creator>Taylor, Kay</creator><creator>Waterton, John C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198908</creationdate><title>High-Resolution NMR imaging of an antigen-induced arthritis in the Rabbit Knee</title><author>Checkley, David ; Johnstone, Donna ; Taylor, Kay ; Waterton, John C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4070-459dc33efc7b32caa698692b55c3b065d26e3f2686f7cc991f104c6ba1f4df963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Arthritis - pathology</topic><topic>Arthritis, Experimental - pathology</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - pathology</topic><topic>Diseases of the osteoarticular system</topic><topic>Inflammatory joint diseases</topic><topic>Knee</topic><topic>Lymph Nodes - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscles - pathology</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Checkley, David</creatorcontrib><creatorcontrib>Johnstone, Donna</creatorcontrib><creatorcontrib>Taylor, Kay</creatorcontrib><creatorcontrib>Waterton, John C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Checkley, David</au><au>Johnstone, Donna</au><au>Taylor, Kay</au><au>Waterton, John C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-Resolution NMR imaging of an antigen-induced arthritis in the Rabbit Knee</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1989-08</date><risdate>1989</risdate><volume>11</volume><issue>2</issue><spage>221</spage><epage>235</epage><pages>221-235</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>High‐resolution, serial, spin‐echo images were obtained for an antigen‐induced knee arthritis in six rabbits. The animals were imaged prior to intra‐articular challenge and at various time points up to 14 weeks after challenge. Extensive high‐signal inflammatory changes were seen at Day 1 in the lymph node, capsule, and surrounding muscle. The muscle and lymph node response decreased rapidly after the first week. The capsule high‐signal area reached a maximum at Day 10, but was still extensive at Day 39. The infrapatellar fat pad was replaced more slowly by high signal and the appearance of high signal in both the tibia and femur was a late change. Terminal histological examination showed that the capsule and fat pad high‐signal areas corresponded to fibrous and synovial proliferation. The bone changes were a result of edema and cyst formation. The separation of the various time courses of the inflammatory changes may be of value in understanding the model and evaluating potential anti‐arthritic drugs. © 1989 Academic Press, Inc.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2779413</pmid><doi>10.1002/mrm.1910110210</doi><tpages>15</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 1989-08, Vol.11 (2), p.221-235 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Arthritis - pathology Arthritis, Experimental - pathology Biological and medical sciences Bone and Bones - pathology Diseases of the osteoarticular system Inflammatory joint diseases Knee Lymph Nodes - pathology Magnetic Resonance Imaging Male Medical sciences Muscles - pathology Rabbits |
| title | High-Resolution NMR imaging of an antigen-induced arthritis in the Rabbit Knee |
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