Behavioral effects of iron supplementation in infants in Madang, Papua New Guinea
The effect of iron supplementation on attending behavior of 96 1-y-old infants was assessed in a double-blind, randomized, controlled trial of iron dextran in Papua New Guinea. The treatment group received an injection of iron dextran at 2 mo; the controls received a placebo injection. Because many...
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| Veröffentlicht in: | The American journal of clinical nutrition 1989-09, Vol.50 (3), p.630-640 |
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| container_title | The American journal of clinical nutrition |
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| creator | Heywood, Alison Oppenheimer, Stephen Heywood, Peter Jolley, Damien |
| description | The effect of iron supplementation on attending behavior of 96 1-y-old infants was assessed in a double-blind, randomized, controlled trial of iron dextran in Papua New Guinea. The treatment group received an injection of iron dextran at 2 mo; the controls received a placebo injection. Because many children had malarial parasitemia at testing, presence of malaria was used in the analysis. A significant interaction was found between iron and malaria infection on total fixation time: iron-supplemented groups and placebo-treated parasitemic children showed significantly higher total fixation scores than did placebo-treated aparasitemic children. Blood analysis of iron status showed similar results, with lowest iron status evident in the placebo-treated aparasitemic group. There was no effect of treatment on rate of habituation or dishabituation. Supplemental iron treatment has a significant effect on attention but the direction of the effect depends on the presence of malaria infection. |
| doi_str_mv | 10.1093/ajcn/50.3.630 |
| format | Article |
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The treatment group received an injection of iron dextran at 2 mo; the controls received a placebo injection. Because many children had malarial parasitemia at testing, presence of malaria was used in the analysis. A significant interaction was found between iron and malaria infection on total fixation time: iron-supplemented groups and placebo-treated parasitemic children showed significantly higher total fixation scores than did placebo-treated aparasitemic children. Blood analysis of iron status showed similar results, with lowest iron status evident in the placebo-treated aparasitemic group. There was no effect of treatment on rate of habituation or dishabituation. Supplemental iron treatment has a significant effect on attention but the direction of the effect depends on the presence of malaria infection.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/50.3.630</identifier><identifier>PMID: 2773841</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anemia, Hypochromic - complications ; Anemia, Hypochromic - drug therapy ; Attention - drug effects ; behavior ; Birth Weight ; Child Behavior - drug effects ; Female ; Ferritins - analysis ; Hemoglobins - analysis ; Humans ; Infant ; infants ; Iron - blood ; Iron - deficiency ; Iron Supplementation ; Iron-Dextran Complex - pharmacology ; Iron-Dextran Complex - therapeutic use ; Male ; New Guinea ; Transferrin - analysis ; visual attention</subject><ispartof>The American journal of clinical nutrition, 1989-09, Vol.50 (3), p.630-640</ispartof><rights>1989 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4aefd9a6a37a1f78ef359d505eb72a136454277b05ef0400ccea5ec33dae020d3</citedby><cites>FETCH-LOGICAL-c375t-4aefd9a6a37a1f78ef359d505eb72a136454277b05ef0400ccea5ec33dae020d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2773841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heywood, Alison</creatorcontrib><creatorcontrib>Oppenheimer, Stephen</creatorcontrib><creatorcontrib>Heywood, Peter</creatorcontrib><creatorcontrib>Jolley, Damien</creatorcontrib><title>Behavioral effects of iron supplementation in infants in Madang, Papua New Guinea</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>The effect of iron supplementation on attending behavior of 96 1-y-old infants was assessed in a double-blind, randomized, controlled trial of iron dextran in Papua New Guinea. The treatment group received an injection of iron dextran at 2 mo; the controls received a placebo injection. Because many children had malarial parasitemia at testing, presence of malaria was used in the analysis. A significant interaction was found between iron and malaria infection on total fixation time: iron-supplemented groups and placebo-treated parasitemic children showed significantly higher total fixation scores than did placebo-treated aparasitemic children. Blood analysis of iron status showed similar results, with lowest iron status evident in the placebo-treated aparasitemic group. There was no effect of treatment on rate of habituation or dishabituation. Supplemental iron treatment has a significant effect on attention but the direction of the effect depends on the presence of malaria infection.</description><subject>Anemia, Hypochromic - complications</subject><subject>Anemia, Hypochromic - drug therapy</subject><subject>Attention - drug effects</subject><subject>behavior</subject><subject>Birth Weight</subject><subject>Child Behavior - drug effects</subject><subject>Female</subject><subject>Ferritins - analysis</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Infant</subject><subject>infants</subject><subject>Iron - blood</subject><subject>Iron - deficiency</subject><subject>Iron Supplementation</subject><subject>Iron-Dextran Complex - pharmacology</subject><subject>Iron-Dextran Complex - therapeutic use</subject><subject>Male</subject><subject>New Guinea</subject><subject>Transferrin - analysis</subject><subject>visual attention</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LxDAQhoMoun4cPQo9ebLrpGma7VEXXYX1C_QcZtOJZum2NWkV_71ZdvEmBCaZeXiZPIydchhzKMUlLk1zKWEsxoWAHTbipZikIgO1y0YAkKUlL-QBOwxhCcCzfFLss_1MKTHJ-Yi9XNMHfrnWY52QtWT6kLQ2cb5tkjB0XU0ranrsXXy79bHYRCReH7DC5v0iecZuwOSRvpPZ4BrCY7ZnsQ50sq1H7O325nV6l86fZvfTq3lqhJJ9miPZqsQChUJu1YSskGUlQdJCZchFkcs8brmIDQs5gDGEkowQFRJkUIkjdr7J7Xz7OVDo9coFQ3WNDbVD0KrkZVlAHsF0AxrfhuDJ6s67FfofzUGvFeq1Qi1BCx0VRv5sGzwsVlT90Vtnca42c4q_-3LkdTCOGkOV89Gfrlr3T_Iv-E2AHA</recordid><startdate>19890901</startdate><enddate>19890901</enddate><creator>Heywood, Alison</creator><creator>Oppenheimer, Stephen</creator><creator>Heywood, Peter</creator><creator>Jolley, Damien</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890901</creationdate><title>Behavioral effects of iron supplementation in infants in Madang, Papua New Guinea</title><author>Heywood, Alison ; Oppenheimer, Stephen ; Heywood, Peter ; Jolley, Damien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4aefd9a6a37a1f78ef359d505eb72a136454277b05ef0400ccea5ec33dae020d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Anemia, Hypochromic - complications</topic><topic>Anemia, Hypochromic - drug therapy</topic><topic>Attention - drug effects</topic><topic>behavior</topic><topic>Birth Weight</topic><topic>Child Behavior - drug effects</topic><topic>Female</topic><topic>Ferritins - analysis</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Infant</topic><topic>infants</topic><topic>Iron - blood</topic><topic>Iron - deficiency</topic><topic>Iron Supplementation</topic><topic>Iron-Dextran Complex - pharmacology</topic><topic>Iron-Dextran Complex - therapeutic use</topic><topic>Male</topic><topic>New Guinea</topic><topic>Transferrin - analysis</topic><topic>visual attention</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heywood, Alison</creatorcontrib><creatorcontrib>Oppenheimer, Stephen</creatorcontrib><creatorcontrib>Heywood, Peter</creatorcontrib><creatorcontrib>Jolley, Damien</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heywood, Alison</au><au>Oppenheimer, Stephen</au><au>Heywood, Peter</au><au>Jolley, Damien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral effects of iron supplementation in infants in Madang, Papua New Guinea</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1989-09-01</date><risdate>1989</risdate><volume>50</volume><issue>3</issue><spage>630</spage><epage>640</epage><pages>630-640</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>The effect of iron supplementation on attending behavior of 96 1-y-old infants was assessed in a double-blind, randomized, controlled trial of iron dextran in Papua New Guinea. 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| issn | 0002-9165 1938-3207 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Anemia, Hypochromic - complications Anemia, Hypochromic - drug therapy Attention - drug effects behavior Birth Weight Child Behavior - drug effects Female Ferritins - analysis Hemoglobins - analysis Humans Infant infants Iron - blood Iron - deficiency Iron Supplementation Iron-Dextran Complex - pharmacology Iron-Dextran Complex - therapeutic use Male New Guinea Transferrin - analysis visual attention |
| title | Behavioral effects of iron supplementation in infants in Madang, Papua New Guinea |
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