CGP 38 560: Orally Active, Low-Molecular-Weight Renin Inhibitor with High Potency and Specificity

CGP 38 560 is a low-molecular-weight (730) inhibitor of human renin that contains only one natural amino acid. In vitro, it is a potent inhibitor of human renin (Ki with tetradecapeptide, 0.4 × 10 M). It has a high enzyme specificity (Ki values against human pepsin, gastricsin, and cathepsin D are 5...

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