Definition of a Physiologic Pharmacokinetic Model of Cutaneous Drug Distribution Using the Isolated Perfused Porcine Skin Flap

A physiologic pharmacokinetic model describing drug disposition in the isolated perfused porcine skin flap (IPPSF) is derived. The IPPSF is well suited for experimental studies of dynamic drug distribution into skin because arterial and venous drug fluxes can be continuously monitored. The system pa...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1989-07, Vol.78 (7), p.550-555
Hauptverfasser:	Williams, Patrick L., Edmond Riviere, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Biological and medical sciences Carboplatin Cisplatin - administration & dosage Cisplatin - pharmacokinetics Doxycycline - administration & dosage Doxycycline - pharmacokinetics General pharmacology In Vitro Techniques Medical sciences Models, Biological Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - pharmacokinetics Perfusion Pharmaceutical Preparations - metabolism Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Skin - metabolism Swine Tetracycline - administration & dosage Tetracycline - pharmacokinetics
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