Differential cognitive effects of terfenadine and chlorpheniramine
The H 1-histamine antagonist, terfenadine, has been proposed to have reduced cognitive side effects. In the present study, the relative cognitive effects of terfenadine, 60 mg, chlorpheniramine maleate, 8 mg, and placebo were tested with a double-blind, randomized, three-period crossover design in 2...
Gespeichert in:
| Veröffentlicht in: | Journal of allergy and clinical immunology 1989-09, Vol.84 (3), p.322-325 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 325 |
|---|---|
| container_issue | 3 |
| container_start_page | 322 |
| container_title | Journal of allergy and clinical immunology |
| container_volume | 84 |
| creator | Meador, Kimford J. Loring, David W. Thompson, Elaine E. Thompson, William O. |
| description | The H
1-histamine antagonist, terfenadine, has been proposed to have reduced cognitive side effects. In the present study, the relative cognitive effects of terfenadine, 60 mg, chlorpheniramine maleate, 8 mg, and placebo were tested with a double-blind, randomized, three-period crossover design in 24 healthy adult subjects. The dependent variable was latency of the P3-evoked potential. The P3 is a cognitively evoked electroencephalographic response that is an objective and sensitive measure of sustained attention and cerebral processing speed. Disease and drug states that adversely affect the central nervous system can slow P3 latency. For example, the centrally active anticholinergic scopolamine slows cognitive processing speed and prolongs P3 latency. P3 latency (millisecond) means (±mean standard error) were pretreatment, 310 (±1.7); placebo, 313 (±3); terfenadine, 320 (±3); and chlorpheniramine, 333 (±3). The findings suggest that terfenadine may be particularly advantageous in patients who require alertness and intact cognitive abilities. |
| doi_str_mv | 10.1016/0091-6749(89)90415-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79198413</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0091674989904156</els_id><sourcerecordid>79198413</sourcerecordid><originalsourceid>FETCH-LOGICAL-c464t-52e16866faeb426c5716ad41a41251ca5bb3bcfbc3c8920f9e1ea68f4cd6a7e83</originalsourceid><addsrcrecordid>eNqFkE1rGzEQhkVJcJ20_6CFvSQkh201u_q8FBrnEwy9tGeh1Y4ahbXWkdaB_PvKtUluyWmYmWdeiYeQL0C_AQXxnVINtZBMnyl9rikDXosPZA5Uy1qohh-Q-QvykRzl_EBL3yo9I7OGSyq1npOLy-A9JoxTsEPlxr8xTOEJKyxTN-Vq9NWEyWO0fYhY2dhX7n4Y0_oeY0h2VYafyKG3Q8bP-3pM_lxf_V7c1stfN3eLn8vaMcGmmjcIQgnhLXasEY5LELZnYBk0HJzlXdd2zneudUo31GsEtEJ55nphJar2mJzuctdpfNxgnswqZIfDYCOOm2ykBq0YtO-CwFspyxMFZDvQpTHnhN6sU1jZ9GyAmq1jsxVotgKN0ua_YyPK2dd9_qZbYf9ytJda9if7vc3ODj7Z6EJ-zdYlkDdQuB87Dou1p4DJZBcwOuxDKvJNP4a3P_IPdWiYjA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15377920</pqid></control><display><type>article</type><title>Differential cognitive effects of terfenadine and chlorpheniramine</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Meador, Kimford J. ; Loring, David W. ; Thompson, Elaine E. ; Thompson, William O.</creator><creatorcontrib>Meador, Kimford J. ; Loring, David W. ; Thompson, Elaine E. ; Thompson, William O.</creatorcontrib><description>The H
1-histamine antagonist, terfenadine, has been proposed to have reduced cognitive side effects. In the present study, the relative cognitive effects of terfenadine, 60 mg, chlorpheniramine maleate, 8 mg, and placebo were tested with a double-blind, randomized, three-period crossover design in 24 healthy adult subjects. The dependent variable was latency of the P3-evoked potential. The P3 is a cognitively evoked electroencephalographic response that is an objective and sensitive measure of sustained attention and cerebral processing speed. Disease and drug states that adversely affect the central nervous system can slow P3 latency. For example, the centrally active anticholinergic scopolamine slows cognitive processing speed and prolongs P3 latency. P3 latency (millisecond) means (±mean standard error) were pretreatment, 310 (±1.7); placebo, 313 (±3); terfenadine, 320 (±3); and chlorpheniramine, 333 (±3). The findings suggest that terfenadine may be particularly advantageous in patients who require alertness and intact cognitive abilities.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/0091-6749(89)90415-6</identifier><identifier>PMID: 2570799</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Benzhydryl Compounds - pharmacology ; Biological and medical sciences ; Chlorpheniramine - pharmacology ; Cognition - drug effects ; Double-Blind Method ; Evoked Potentials, Somatosensory - drug effects ; Female ; Histamine and antagonists. Allergy ; Histamine H1 Antagonists - pharmacology ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Random Allocation ; Reaction Time - drug effects ; Terfenadine</subject><ispartof>Journal of allergy and clinical immunology, 1989-09, Vol.84 (3), p.322-325</ispartof><rights>1989</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-52e16866faeb426c5716ad41a41251ca5bb3bcfbc3c8920f9e1ea68f4cd6a7e83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-6749(89)90415-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19674521$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2570799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meador, Kimford J.</creatorcontrib><creatorcontrib>Loring, David W.</creatorcontrib><creatorcontrib>Thompson, Elaine E.</creatorcontrib><creatorcontrib>Thompson, William O.</creatorcontrib><title>Differential cognitive effects of terfenadine and chlorpheniramine</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>The H
1-histamine antagonist, terfenadine, has been proposed to have reduced cognitive side effects. In the present study, the relative cognitive effects of terfenadine, 60 mg, chlorpheniramine maleate, 8 mg, and placebo were tested with a double-blind, randomized, three-period crossover design in 24 healthy adult subjects. The dependent variable was latency of the P3-evoked potential. The P3 is a cognitively evoked electroencephalographic response that is an objective and sensitive measure of sustained attention and cerebral processing speed. Disease and drug states that adversely affect the central nervous system can slow P3 latency. For example, the centrally active anticholinergic scopolamine slows cognitive processing speed and prolongs P3 latency. P3 latency (millisecond) means (±mean standard error) were pretreatment, 310 (±1.7); placebo, 313 (±3); terfenadine, 320 (±3); and chlorpheniramine, 333 (±3). The findings suggest that terfenadine may be particularly advantageous in patients who require alertness and intact cognitive abilities.</description><subject>Adult</subject><subject>Benzhydryl Compounds - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chlorpheniramine - pharmacology</subject><subject>Cognition - drug effects</subject><subject>Double-Blind Method</subject><subject>Evoked Potentials, Somatosensory - drug effects</subject><subject>Female</subject><subject>Histamine and antagonists. Allergy</subject><subject>Histamine H1 Antagonists - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Random Allocation</subject><subject>Reaction Time - drug effects</subject><subject>Terfenadine</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVJcJ20_6CFvSQkh201u_q8FBrnEwy9tGeh1Y4ahbXWkdaB_PvKtUluyWmYmWdeiYeQL0C_AQXxnVINtZBMnyl9rikDXosPZA5Uy1qohh-Q-QvykRzl_EBL3yo9I7OGSyq1npOLy-A9JoxTsEPlxr8xTOEJKyxTN-Vq9NWEyWO0fYhY2dhX7n4Y0_oeY0h2VYafyKG3Q8bP-3pM_lxf_V7c1stfN3eLn8vaMcGmmjcIQgnhLXasEY5LELZnYBk0HJzlXdd2zneudUo31GsEtEJ55nphJar2mJzuctdpfNxgnswqZIfDYCOOm2ykBq0YtO-CwFspyxMFZDvQpTHnhN6sU1jZ9GyAmq1jsxVotgKN0ua_YyPK2dd9_qZbYf9ytJda9if7vc3ODj7Z6EJ-zdYlkDdQuB87Dou1p4DJZBcwOuxDKvJNP4a3P_IPdWiYjA</recordid><startdate>19890901</startdate><enddate>19890901</enddate><creator>Meador, Kimford J.</creator><creator>Loring, David W.</creator><creator>Thompson, Elaine E.</creator><creator>Thompson, William O.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19890901</creationdate><title>Differential cognitive effects of terfenadine and chlorpheniramine</title><author>Meador, Kimford J. ; Loring, David W. ; Thompson, Elaine E. ; Thompson, William O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-52e16866faeb426c5716ad41a41251ca5bb3bcfbc3c8920f9e1ea68f4cd6a7e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Benzhydryl Compounds - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chlorpheniramine - pharmacology</topic><topic>Cognition - drug effects</topic><topic>Double-Blind Method</topic><topic>Evoked Potentials, Somatosensory - drug effects</topic><topic>Female</topic><topic>Histamine and antagonists. Allergy</topic><topic>Histamine H1 Antagonists - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Random Allocation</topic><topic>Reaction Time - drug effects</topic><topic>Terfenadine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meador, Kimford J.</creatorcontrib><creatorcontrib>Loring, David W.</creatorcontrib><creatorcontrib>Thompson, Elaine E.</creatorcontrib><creatorcontrib>Thompson, William O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meador, Kimford J.</au><au>Loring, David W.</au><au>Thompson, Elaine E.</au><au>Thompson, William O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential cognitive effects of terfenadine and chlorpheniramine</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1989-09-01</date><risdate>1989</risdate><volume>84</volume><issue>3</issue><spage>322</spage><epage>325</epage><pages>322-325</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>The H
1-histamine antagonist, terfenadine, has been proposed to have reduced cognitive side effects. In the present study, the relative cognitive effects of terfenadine, 60 mg, chlorpheniramine maleate, 8 mg, and placebo were tested with a double-blind, randomized, three-period crossover design in 24 healthy adult subjects. The dependent variable was latency of the P3-evoked potential. The P3 is a cognitively evoked electroencephalographic response that is an objective and sensitive measure of sustained attention and cerebral processing speed. Disease and drug states that adversely affect the central nervous system can slow P3 latency. For example, the centrally active anticholinergic scopolamine slows cognitive processing speed and prolongs P3 latency. P3 latency (millisecond) means (±mean standard error) were pretreatment, 310 (±1.7); placebo, 313 (±3); terfenadine, 320 (±3); and chlorpheniramine, 333 (±3). The findings suggest that terfenadine may be particularly advantageous in patients who require alertness and intact cognitive abilities.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>2570799</pmid><doi>10.1016/0091-6749(89)90415-6</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 1989-09, Vol.84 (3), p.322-325 |
| issn | 0091-6749 1097-6825 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79198413 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Benzhydryl Compounds - pharmacology Biological and medical sciences Chlorpheniramine - pharmacology Cognition - drug effects Double-Blind Method Evoked Potentials, Somatosensory - drug effects Female Histamine and antagonists. Allergy Histamine H1 Antagonists - pharmacology Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Random Allocation Reaction Time - drug effects Terfenadine |
| title | Differential cognitive effects of terfenadine and chlorpheniramine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T22%3A42%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20cognitive%20effects%20of%20terfenadine%20and%20chlorpheniramine&rft.jtitle=Journal%20of%20allergy%20and%20clinical%20immunology&rft.au=Meador,%20Kimford%20J.&rft.date=1989-09-01&rft.volume=84&rft.issue=3&rft.spage=322&rft.epage=325&rft.pages=322-325&rft.issn=0091-6749&rft.eissn=1097-6825&rft.coden=JACIBY&rft_id=info:doi/10.1016/0091-6749(89)90415-6&rft_dat=%3Cproquest_cross%3E79198413%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15377920&rft_id=info:pmid/2570799&rft_els_id=0091674989904156&rfr_iscdi=true |