UPPER GASTROINTESTINAL CANCER IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS
102 patients with familial adenomatous polyposis underwent upper gastrointestinal endoscopy as a screening test for gastroduodenal adenomas. 100 had duodenal abnormalities (dysplasia in 94, and hyperplasia in 6), usually in the second and third parts of the duodenum (91%). The periampullary area was...
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| Veröffentlicht in: | The Lancet (British edition) 1989-09, Vol.334 (8666), p.783-785 |
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| creator | Spigelman, AllanD Talbot, I.C. Williams, C.B. Domizio, P. Phillips, R.K.S. |
| description | 102 patients with familial adenomatous polyposis underwent upper gastrointestinal endoscopy as a screening test for gastroduodenal adenomas. 100 had duodenal abnormalities (dysplasia in 94, and hyperplasia in 6), usually in the second and third parts of the duodenum (91%). The periampullary area was abnormal in 87 of 97 patients who had a biopsy specimen taken from this site (dysplasia 72, hyperplasia 13, and inflammation 2). By contrast, gastric dysplasia was found in only 6 patients. Classification of duodenal polyposis on a 5-grade scale (stages 0-IV), based on polyp number, size, histology, and severity of dysplasia, showed that 11 had stage IV disease: these patients are at greatest risk of malignant change and require close surveillance. The pattern of dysplasia observed in the upper gastrointestinal tract resembled the pattern of mucosal exposure to bile. |
| doi_str_mv | 10.1016/S0140-6736(89)90840-4 |
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The periampullary area was abnormal in 87 of 97 patients who had a biopsy specimen taken from this site (dysplasia 72, hyperplasia 13, and inflammation 2). By contrast, gastric dysplasia was found in only 6 patients. Classification of duodenal polyposis on a 5-grade scale (stages 0-IV), based on polyp number, size, histology, and severity of dysplasia, showed that 11 had stage IV disease: these patients are at greatest risk of malignant change and require close surveillance. The pattern of dysplasia observed in the upper gastrointestinal tract resembled the pattern of mucosal exposure to bile.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(89)90840-4</identifier><identifier>PMID: 2571019</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adenoma - etiology ; Adenoma - pathology ; Adenomatous Polyposis Coli - complications ; Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cancer ; Digestive system ; Duodenal Neoplasms - etiology ; Duodenal Neoplasms - pathology ; Duodenoscopy ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal tract ; Health care ; Histology ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Prospective Studies ; Pyloric Antrum - pathology ; Retrospective Studies ; Risk Factors ; Sampling Studies ; Stomach Neoplasms - etiology ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>The Lancet (British edition), 1989-09, Vol.334 (8666), p.783-785</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><rights>Copyright Lancet Ltd. 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The periampullary area was abnormal in 87 of 97 patients who had a biopsy specimen taken from this site (dysplasia 72, hyperplasia 13, and inflammation 2). By contrast, gastric dysplasia was found in only 6 patients. Classification of duodenal polyposis on a 5-grade scale (stages 0-IV), based on polyp number, size, histology, and severity of dysplasia, showed that 11 had stage IV disease: these patients are at greatest risk of malignant change and require close surveillance. The pattern of dysplasia observed in the upper gastrointestinal tract resembled the pattern of mucosal exposure to bile.</description><subject>Adenoma - etiology</subject><subject>Adenoma - pathology</subject><subject>Adenomatous Polyposis Coli - complications</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Digestive system</subject><subject>Duodenal Neoplasms - etiology</subject><subject>Duodenal Neoplasms - pathology</subject><subject>Duodenoscopy</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal tract</subject><subject>Health care</subject><subject>Histology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Prospective Studies</subject><subject>Pyloric Antrum - pathology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sampling Studies</subject><subject>Stomach Neoplasms - etiology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1r2zAUhkXZ6NKPn1AwY4ztwptky_q4KiZzW4Fjm9qh25WQJRlckriTksL-_ZQm5GI3uxLSec7LqweAGwS_IYjI9xYiDGNCU_KF8a8csnDDZ2CGMMVxhunPd2B2Qj6AC--fIYSYwOwcnCcZDSF8BhbLpikeo_u87R5rUXVF24kqL6N5Xs3Du6iiJu9EUXVt9CS6h-guX4hSBCD_UVT1Iu_qZRs1dfmrqVvRXoH3g1p5e308L8HyrujmD3FZ34t5XsYaE7aNKWGpVmkPleGQKmwHjRNoUZLgQWUIJZwzw41hFiapsYMiXNHeGoNNz3RP0kvw-ZD74qbfO-u3cj16bVcrtbHTzkvKESecwAB-_Ad8nnZuE7pJxBnPKE-zAGUHSLvJe2cH-eLGtXJ_JIJy71q-uZZ7kZJx-eZa4rB3cwzf9WtrTltHuWH-6ThXXqvV4NRGj_6EkdCS4f1nbg-YDcZeR-uk16PdaGtGZ_VWmmn8T5G_GHqT2g</recordid><startdate>19890930</startdate><enddate>19890930</enddate><creator>Spigelman, AllanD</creator><creator>Talbot, I.C.</creator><creator>Williams, C.B.</creator><creator>Domizio, P.</creator><creator>Phillips, R.K.S.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19890930</creationdate><title>UPPER GASTROINTESTINAL CANCER IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS</title><author>Spigelman, AllanD ; Talbot, I.C. ; Williams, C.B. ; Domizio, P. ; Phillips, R.K.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-7683ca3b0ad907a4efc420e1224fa5112998d9dd8e023defa69a7bedd4db8cb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adenoma - etiology</topic><topic>Adenoma - pathology</topic><topic>Adenomatous Polyposis Coli - complications</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Digestive system</topic><topic>Duodenal Neoplasms - etiology</topic><topic>Duodenal Neoplasms - pathology</topic><topic>Duodenoscopy</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal tract</topic><topic>Health care</topic><topic>Histology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Prospective Studies</topic><topic>Pyloric Antrum - pathology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sampling Studies</topic><topic>Stomach Neoplasms - etiology</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spigelman, AllanD</creatorcontrib><creatorcontrib>Talbot, I.C.</creatorcontrib><creatorcontrib>Williams, C.B.</creatorcontrib><creatorcontrib>Domizio, P.</creatorcontrib><creatorcontrib>Phillips, R.K.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spigelman, AllanD</au><au>Talbot, I.C.</au><au>Williams, C.B.</au><au>Domizio, P.</au><au>Phillips, R.K.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>UPPER GASTROINTESTINAL CANCER IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1989-09-30</date><risdate>1989</risdate><volume>334</volume><issue>8666</issue><spage>783</spage><epage>785</epage><pages>783-785</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>102 patients with familial adenomatous polyposis underwent upper gastrointestinal endoscopy as a screening test for gastroduodenal adenomas. 100 had duodenal abnormalities (dysplasia in 94, and hyperplasia in 6), usually in the second and third parts of the duodenum (91%). 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| subjects | Adenoma - etiology Adenoma - pathology Adenomatous Polyposis Coli - complications Adolescent Adult Aged Biological and medical sciences Cancer Digestive system Duodenal Neoplasms - etiology Duodenal Neoplasms - pathology Duodenoscopy Female Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal tract Health care Histology Humans Male Medical sciences Middle Aged Neoplasm Staging Prospective Studies Pyloric Antrum - pathology Retrospective Studies Risk Factors Sampling Studies Stomach Neoplasms - etiology Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | UPPER GASTROINTESTINAL CANCER IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS |
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