Single-dose intravenous H2 blocker prophylaxis against aspiration pneumonitis: assessment of drug concentration in gastric aspirate
This placebo-controlled trial compared the effects of preoperative, intravenous cimetidine (300 mg) or ranitidine (50 mg) on gastric pH and gastric volume in 31 adult patients requiring general anesthesia. The elapsed time from drug administration to initial gastric sampling did not differ significa...
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| Veröffentlicht in: | AANA journal 1989-06, Vol.57 (3), p.238-243 |
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| creator | Gonzalez, E R Kallar, S K Dunnavant, B W |
| description | This placebo-controlled trial compared the effects of preoperative, intravenous cimetidine (300 mg) or ranitidine (50 mg) on gastric pH and gastric volume in 31 adult patients requiring general anesthesia. The elapsed time from drug administration to initial gastric sampling did not differ significantly between ranitidine (45 minutes), cimetidine (48 minutes), or placebo (52 minutes) treated patients. Ranitidine, but not cimetidine, significantly (P = 0.02) increased gastric pH when compared with placebo. Gastric pH correlated (r = 0.7, P = 0.01) with cimetidine concentration in gastric fluid at induction. Gastric pH was directly proportional to ranitidine concentration in gastric fluid at induction, but the correlation was weak (r = 0.54, P = 0.1). The H2 blockers did not significantly alter gastric volume when compared with placebo. The number of patients with gastric pH less than = 2.5 and gastric volume = greater than 25 ml did not differ significantly between cimetidine (8%), ranitidine (10%), and placebo (22%). No clinical evidence of aspiration pneumonitis was found in our study patients. |
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The elapsed time from drug administration to initial gastric sampling did not differ significantly between ranitidine (45 minutes), cimetidine (48 minutes), or placebo (52 minutes) treated patients. Ranitidine, but not cimetidine, significantly (P = 0.02) increased gastric pH when compared with placebo. Gastric pH correlated (r = 0.7, P = 0.01) with cimetidine concentration in gastric fluid at induction. Gastric pH was directly proportional to ranitidine concentration in gastric fluid at induction, but the correlation was weak (r = 0.54, P = 0.1). The H2 blockers did not significantly alter gastric volume when compared with placebo. The number of patients with gastric pH less than = 2.5 and gastric volume = greater than 25 ml did not differ significantly between cimetidine (8%), ranitidine (10%), and placebo (22%). No clinical evidence of aspiration pneumonitis was found in our study patients.</description><identifier>ISSN: 0094-6354</identifier><identifier>PMID: 2773628</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Anesthesia, General - adverse effects ; Cimetidine - analysis ; Cimetidine - pharmacology ; Cimetidine - therapeutic use ; Double-Blind Method ; Female ; Gastric Acidity Determination ; Gastric Juice - analysis ; Gastric Juice - drug effects ; Humans ; Male ; Nursing ; Pneumonia, Aspiration - drug therapy ; Pneumonia, Aspiration - etiology ; Premedication ; Ranitidine - analysis ; Ranitidine - pharmacology ; Ranitidine - therapeutic use</subject><ispartof>AANA journal, 1989-06, Vol.57 (3), p.238-243</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2773628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonzalez, E R</creatorcontrib><creatorcontrib>Kallar, S K</creatorcontrib><creatorcontrib>Dunnavant, B W</creatorcontrib><title>Single-dose intravenous H2 blocker prophylaxis against aspiration pneumonitis: assessment of drug concentration in gastric aspirate</title><title>AANA journal</title><addtitle>AANA J</addtitle><description>This placebo-controlled trial compared the effects of preoperative, intravenous cimetidine (300 mg) or ranitidine (50 mg) on gastric pH and gastric volume in 31 adult patients requiring general anesthesia. The elapsed time from drug administration to initial gastric sampling did not differ significantly between ranitidine (45 minutes), cimetidine (48 minutes), or placebo (52 minutes) treated patients. Ranitidine, but not cimetidine, significantly (P = 0.02) increased gastric pH when compared with placebo. Gastric pH correlated (r = 0.7, P = 0.01) with cimetidine concentration in gastric fluid at induction. Gastric pH was directly proportional to ranitidine concentration in gastric fluid at induction, but the correlation was weak (r = 0.54, P = 0.1). The H2 blockers did not significantly alter gastric volume when compared with placebo. The number of patients with gastric pH less than = 2.5 and gastric volume = greater than 25 ml did not differ significantly between cimetidine (8%), ranitidine (10%), and placebo (22%). No clinical evidence of aspiration pneumonitis was found in our study patients.</description><subject>Adult</subject><subject>Anesthesia, General - adverse effects</subject><subject>Cimetidine - analysis</subject><subject>Cimetidine - pharmacology</subject><subject>Cimetidine - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gastric Acidity Determination</subject><subject>Gastric Juice - analysis</subject><subject>Gastric Juice - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Nursing</subject><subject>Pneumonia, Aspiration - drug therapy</subject><subject>Pneumonia, Aspiration - etiology</subject><subject>Premedication</subject><subject>Ranitidine - analysis</subject><subject>Ranitidine - pharmacology</subject><subject>Ranitidine - therapeutic use</subject><issn>0094-6354</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1KxDAYRbtQxnH0EYSs3BXy16RxJ4M6woALdV0yydcabZOapOKsfXGrjqsLl8OBe4-KJcaKl4JV_KQ4TekVYyIE54tiQaVkgtbL4uvR-a6H0oYEyPkc9Qf4MCW0oWjXB_MGEY0xjC_7Xn-6hHSnnU8Z6TS6qLMLHo0epiF4l126mvsEKQ3gMwotsnHqkAnewI_5l3YedTrl6My_A86K41b3Cc4PuSqeb2-e1pty-3B3v77eliOhJJfWiKquhLTKsLaqCBWW7SSugQtmFddUEktaKSimihDFADDw2tqaG40VpWxVXP5550HvE6TcDC4Z6HvtYZ7cSEWUqEQ9gxcHcNoNYJsxukHHfXN4jX0DtNRq1A</recordid><startdate>198906</startdate><enddate>198906</enddate><creator>Gonzalez, E R</creator><creator>Kallar, S K</creator><creator>Dunnavant, B W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198906</creationdate><title>Single-dose intravenous H2 blocker prophylaxis against aspiration pneumonitis: assessment of drug concentration in gastric aspirate</title><author>Gonzalez, E R ; Kallar, S K ; Dunnavant, B W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-dc658567d9c3f55126d3b708e463d94a271d1f7620291193ee0e48dd84ca09223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Anesthesia, General - adverse effects</topic><topic>Cimetidine - analysis</topic><topic>Cimetidine - pharmacology</topic><topic>Cimetidine - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gastric Acidity Determination</topic><topic>Gastric Juice - analysis</topic><topic>Gastric Juice - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Nursing</topic><topic>Pneumonia, Aspiration - drug therapy</topic><topic>Pneumonia, Aspiration - etiology</topic><topic>Premedication</topic><topic>Ranitidine - analysis</topic><topic>Ranitidine - pharmacology</topic><topic>Ranitidine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonzalez, E R</creatorcontrib><creatorcontrib>Kallar, S K</creatorcontrib><creatorcontrib>Dunnavant, B W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>AANA journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonzalez, E R</au><au>Kallar, S K</au><au>Dunnavant, B W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-dose intravenous H2 blocker prophylaxis against aspiration pneumonitis: assessment of drug concentration in gastric aspirate</atitle><jtitle>AANA journal</jtitle><addtitle>AANA J</addtitle><date>1989-06</date><risdate>1989</risdate><volume>57</volume><issue>3</issue><spage>238</spage><epage>243</epage><pages>238-243</pages><issn>0094-6354</issn><abstract>This placebo-controlled trial compared the effects of preoperative, intravenous cimetidine (300 mg) or ranitidine (50 mg) on gastric pH and gastric volume in 31 adult patients requiring general anesthesia. The elapsed time from drug administration to initial gastric sampling did not differ significantly between ranitidine (45 minutes), cimetidine (48 minutes), or placebo (52 minutes) treated patients. Ranitidine, but not cimetidine, significantly (P = 0.02) increased gastric pH when compared with placebo. Gastric pH correlated (r = 0.7, P = 0.01) with cimetidine concentration in gastric fluid at induction. Gastric pH was directly proportional to ranitidine concentration in gastric fluid at induction, but the correlation was weak (r = 0.54, P = 0.1). The H2 blockers did not significantly alter gastric volume when compared with placebo. The number of patients with gastric pH less than = 2.5 and gastric volume = greater than 25 ml did not differ significantly between cimetidine (8%), ranitidine (10%), and placebo (22%). No clinical evidence of aspiration pneumonitis was found in our study patients.</abstract><cop>United States</cop><pmid>2773628</pmid><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0094-6354 |
| ispartof | AANA journal, 1989-06, Vol.57 (3), p.238-243 |
| issn | 0094-6354 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Anesthesia, General - adverse effects Cimetidine - analysis Cimetidine - pharmacology Cimetidine - therapeutic use Double-Blind Method Female Gastric Acidity Determination Gastric Juice - analysis Gastric Juice - drug effects Humans Male Nursing Pneumonia, Aspiration - drug therapy Pneumonia, Aspiration - etiology Premedication Ranitidine - analysis Ranitidine - pharmacology Ranitidine - therapeutic use |
| title | Single-dose intravenous H2 blocker prophylaxis against aspiration pneumonitis: assessment of drug concentration in gastric aspirate |
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