Leucocyte intracellular pH and Na+/H + antiport activity in human hypertension
Hypertension is associated with thickening of the wall of resistance vessels, but the cellular or genetic basis of this is unclear. Cell proliferation and intracellular alkalinization via increased Na/H exchange are linked in the response of tissues to growth factors. To define a possible cellular b...
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| Veröffentlicht in: | Journal of hypertension 1989-06, Vol.7 (6), p.471-475 |
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| container_title | Journal of hypertension |
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| creator | Ng, Leong L Dudley, Chris Bomford, Jacqui Hawley, David |
| description | Hypertension is associated with thickening of the wall of resistance vessels, but the cellular or genetic basis of this is unclear. Cell proliferation and intracellular alkalinization via increased Na/H exchange are linked in the response of tissues to growth factors. To define a possible cellular basis for vascular medial thickening in hypertension, we studied leucocyte intracellular pH, buffering power and Na /H antiport activity in 17 hypertensive and 17 age-, sex- and weight-matched normotensive subjects. The cells from hypertensive subjects were significantly more alkaline [median (range)7.49 (7.26-7.95) versus 7.39 (7.25-7.53); P |
| doi_str_mv | 10.1097/00004872-198906000-00006 |
| format | Article |
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Cell proliferation and intracellular alkalinization via increased Na/H exchange are linked in the response of tissues to growth factors. To define a possible cellular basis for vascular medial thickening in hypertension, we studied leucocyte intracellular pH, buffering power and Na /H antiport activity in 17 hypertensive and 17 age-, sex- and weight-matched normotensive subjects. The cells from hypertensive subjects were significantly more alkaline [median (range)7.49 (7.26-7.95) versus 7.39 (7.25-7.53); P <0.01], and had a lower buffering power [8.95 (3.05-17.98) versus 12.57 (7.44-19.95) mmol/l per pH unit; P< 0.02] than those from normotensive subjects. Moreover, the activity of the Na/H antiport was higher when cells were acid-loaded to an intracellular pH of 6.7. The presence of a similar increased activity in vascular smooth muscle cells may be associated with increased cellular proliferation resulting in a thickened media or increased vascular smooth muscle contractility.</description><identifier>ISSN: 0263-6352</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/00004872-198906000-00006</identifier><identifier>PMID: 2550540</identifier><identifier>CODEN: JOHYD3</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adult ; Aged ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Platelets - metabolism ; Blood Pressure ; Body Weight ; Cardiology. Vascular system ; Carrier Proteins - blood ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Female ; Humans ; Hypertension - blood ; Leukocytes - metabolism ; Male ; Medical sciences ; Middle Aged ; Sodium-Hydrogen Exchangers</subject><ispartof>Journal of hypertension, 1989-06, Vol.7 (6), p.471-475</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2316-8ddde36494d4d7f2a19c39619026c364d2d19578d2846ba5b2d3fddc6c3aa42f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6581270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2550540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Leong L</creatorcontrib><creatorcontrib>Dudley, Chris</creatorcontrib><creatorcontrib>Bomford, Jacqui</creatorcontrib><creatorcontrib>Hawley, David</creatorcontrib><title>Leucocyte intracellular pH and Na+/H + antiport activity in human hypertension</title><title>Journal of hypertension</title><addtitle>J Hypertens</addtitle><description>Hypertension is associated with thickening of the wall of resistance vessels, but the cellular or genetic basis of this is unclear. Cell proliferation and intracellular alkalinization via increased Na/H exchange are linked in the response of tissues to growth factors. To define a possible cellular basis for vascular medial thickening in hypertension, we studied leucocyte intracellular pH, buffering power and Na /H antiport activity in 17 hypertensive and 17 age-, sex- and weight-matched normotensive subjects. The cells from hypertensive subjects were significantly more alkaline [median (range)7.49 (7.26-7.95) versus 7.39 (7.25-7.53); P <0.01], and had a lower buffering power [8.95 (3.05-17.98) versus 12.57 (7.44-19.95) mmol/l per pH unit; P< 0.02] than those from normotensive subjects. Moreover, the activity of the Na/H antiport was higher when cells were acid-loaded to an intracellular pH of 6.7. The presence of a similar increased activity in vascular smooth muscle cells may be associated with increased cellular proliferation resulting in a thickened media or increased vascular smooth muscle contractility.</description><subject>Adult</subject><subject>Aged</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Platelets - metabolism</subject><subject>Blood Pressure</subject><subject>Body Weight</subject><subject>Cardiology. Vascular system</subject><subject>Carrier Proteins - blood</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Sodium-Hydrogen Exchangers</subject><issn>0263-6352</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kTtPwzAUhS0EgvL4CUgZEAsKjZ-xR4SAIlVlgdm6tR01kCbBdkD99zi0dMODH-d81746RijDxS0uVDkt0mCyJDlWUhUinfJREgdogllJc86VPESTggiaC8rJCToN4T0RUpX0GB0TzgvOiglazN1gOrOJLqvb6MG4phka8Fk_y6C12QJuprPsJu1j3Xc-ZmBi_VXHTcKz1bCGNG9656NrQ9215-iogia4i916ht4eH17vZ_n85en5_m6eG0KxyKW11lHBFLPMlhUBrAxVAqvUsEm6JRYrXkpLJBNL4EtiaWWtSSYAIxU9Q9fbe3vffQ4uRL2uw9g7tK4bgi4VVoJRkUC5BY3vQvCu0r2v1-A3Ghd6jFL_Ran3Uf5KY-nl7o1huXZ2X7jLLvlXOx-Cgaby0Jo67DHBJSbliLEt9t010fnw0QzfzuuVgyau9H8fSX8Aq36KZw</recordid><startdate>198906</startdate><enddate>198906</enddate><creator>Ng, Leong L</creator><creator>Dudley, Chris</creator><creator>Bomford, Jacqui</creator><creator>Hawley, David</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198906</creationdate><title>Leucocyte intracellular pH and Na+/H + antiport activity in human hypertension</title><author>Ng, Leong L ; Dudley, Chris ; Bomford, Jacqui ; Hawley, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2316-8ddde36494d4d7f2a19c39619026c364d2d19578d2846ba5b2d3fddc6c3aa42f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Platelets - metabolism</topic><topic>Blood Pressure</topic><topic>Body Weight</topic><topic>Cardiology. Vascular system</topic><topic>Carrier Proteins - blood</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Sodium-Hydrogen Exchangers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, Leong L</creatorcontrib><creatorcontrib>Dudley, Chris</creatorcontrib><creatorcontrib>Bomford, Jacqui</creatorcontrib><creatorcontrib>Hawley, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Leong L</au><au>Dudley, Chris</au><au>Bomford, Jacqui</au><au>Hawley, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leucocyte intracellular pH and Na+/H + antiport activity in human hypertension</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens</addtitle><date>1989-06</date><risdate>1989</risdate><volume>7</volume><issue>6</issue><spage>471</spage><epage>475</epage><pages>471-475</pages><issn>0263-6352</issn><eissn>1473-5598</eissn><coden>JOHYD3</coden><abstract>Hypertension is associated with thickening of the wall of resistance vessels, but the cellular or genetic basis of this is unclear. Cell proliferation and intracellular alkalinization via increased Na/H exchange are linked in the response of tissues to growth factors. To define a possible cellular basis for vascular medial thickening in hypertension, we studied leucocyte intracellular pH, buffering power and Na /H antiport activity in 17 hypertensive and 17 age-, sex- and weight-matched normotensive subjects. The cells from hypertensive subjects were significantly more alkaline [median (range)7.49 (7.26-7.95) versus 7.39 (7.25-7.53); P <0.01], and had a lower buffering power [8.95 (3.05-17.98) versus 12.57 (7.44-19.95) mmol/l per pH unit; P< 0.02] than those from normotensive subjects. Moreover, the activity of the Na/H antiport was higher when cells were acid-loaded to an intracellular pH of 6.7. The presence of a similar increased activity in vascular smooth muscle cells may be associated with increased cellular proliferation resulting in a thickened media or increased vascular smooth muscle contractility.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>2550540</pmid><doi>10.1097/00004872-198906000-00006</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of hypertension, 1989-06, Vol.7 (6), p.471-475 |
| issn | 0263-6352 1473-5598 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Platelets - metabolism Blood Pressure Body Weight Cardiology. Vascular system Carrier Proteins - blood Clinical manifestations. Epidemiology. Investigative techniques. Etiology Female Humans Hypertension - blood Leukocytes - metabolism Male Medical sciences Middle Aged Sodium-Hydrogen Exchangers |
| title | Leucocyte intracellular pH and Na+/H + antiport activity in human hypertension |
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