Bacterial DNA-Induced NK Cell IFN-γ Production Is Dependent on Macrophage Secretion of IL-12

Bacterial DNA (bDNA) activates B cells and macrophages and can augment inflammatory responses by inducing release of proinflammatory cytokines. We found that bDNA stimulation of mouse spleen cells induced NK cell IFN-γ production that was dependent upon the presence of unmethylated CpG motifs, and o...

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Veröffentlicht in:	Clinical immunology and immunopathology 1997-08, Vol.84 (2), p.185-193
Hauptverfasser:	Chace, Jacqueline H., Hooker, Nick A., Mildenstein, Kristy L., Krieg, Arthur M., Cowdery, John S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Biological and medical sciences DNA, Bacterial - pharmacology Female Fundamental and applied biological sciences. Psychology Interferon-gamma - biosynthesis Interleukin-10 - pharmacology Interleukin-12 - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Macrophage Activation - immunology Macrophages - metabolism Mice Mice, Inbred C57BL Microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Spleen - cytology
Online-Zugang:	Volltext
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