Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells

2',3'-Dideoxyinosine (ddlno) is a potent and selective inhibitor of human immunodeficiency virus in human lymphoid cells and monocytes/macrophages. Earlier studies [J. Biol. Chem. 263:15354 (1988)] showed that anabolism of ddlno in human lymphoid cells is mediated via an initial step of ph...

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Veröffentlicht in:	Molecular pharmacology 1989-08, Vol.36 (2), p.291-295
Hauptverfasser:	JOHNSON, M. A, FRIDLAND, A
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase Adenosine Triphosphate - metabolism AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Deoxyadenine Nucleotides - metabolism Didanosine Dideoxynucleosides - metabolism Dideoxynucleotides Dinucleoside Phosphates - pharmacology Humans In Vitro Techniques Inosine Monophosphate - metabolism Kinetics Medical sciences Nucleotidases - metabolism Pharmacology. Drug treatments Phosphorylation T-Lymphocytes - metabolism
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