A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration
The combination of platelet‐derived growth factor (PDGF) and insulin‐like growth factor one (IGF‐1) has previously been shown to enhance repair of soft tissue wounds. Here we report initial observations following application of PDGF and IGF‐1 to periodontitis‐affected teeth in beagle dogs, 1 μg of P...
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| Veröffentlicht in: | Journal of clinical periodontology 1989-09, Vol.16 (8), p.545-548 |
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| container_title | Journal of clinical periodontology |
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| creator | Lynch, S. E. Williams, R. C. Poison, A. M. Howell, T. H. Reddy, M. S. Zappa, U. E. Antoniades, H. N. |
| description | The combination of platelet‐derived growth factor (PDGF) and insulin‐like growth factor one (IGF‐1) has previously been shown to enhance repair of soft tissue wounds. Here we report initial observations following application of PDGF and IGF‐1 to periodontitis‐affected teeth in beagle dogs, 1 μg of PDGF and IGF‐1 in an aqueous gel was applied to the root surfaces of test teeth following open flap debridement. Control sites received the gel alone. Block biopsies of the teeth and surrounding bone were taken 2 weeks after treatment. Histologic analyses of control specimens revealed a long junctional epithelial attachment, and no new bone or cementum formation. In contrast, growth factor treated sites exhibited significant amounts of new bone and cementum formation. A nearly continuous layer of osteoblasts lined the newly formed bone, and there was a dense cellular “front” at the coronal extent of the new bone. These preliminary results suggest that in vivo application of the combination of PDGF and IGF‐1 may enhance regeneration of the periodontal structures. |
| doi_str_mv | 10.1111/j.1600-051X.1989.tb02334.x |
| format | Article |
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E. ; Williams, R. C. ; Poison, A. M. ; Howell, T. H. ; Reddy, M. S. ; Zappa, U. E. ; Antoniades, H. N.</creator><creatorcontrib>Lynch, S. E. ; Williams, R. C. ; Poison, A. M. ; Howell, T. H. ; Reddy, M. S. ; Zappa, U. E. ; Antoniades, H. N.</creatorcontrib><description>The combination of platelet‐derived growth factor (PDGF) and insulin‐like growth factor one (IGF‐1) has previously been shown to enhance repair of soft tissue wounds. Here we report initial observations following application of PDGF and IGF‐1 to periodontitis‐affected teeth in beagle dogs, 1 μg of PDGF and IGF‐1 in an aqueous gel was applied to the root surfaces of test teeth following open flap debridement. Control sites received the gel alone. Block biopsies of the teeth and surrounding bone were taken 2 weeks after treatment. Histologic analyses of control specimens revealed a long junctional epithelial attachment, and no new bone or cementum formation. In contrast, growth factor treated sites exhibited significant amounts of new bone and cementum formation. A nearly continuous layer of osteoblasts lined the newly formed bone, and there was a dense cellular “front” at the coronal extent of the new bone. These preliminary results suggest that in vivo application of the combination of PDGF and IGF‐1 may enhance regeneration of the periodontal structures.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/j.1600-051X.1989.tb02334.x</identifier><identifier>PMID: 2778088</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Alveolar Process - physiology ; Animals ; bone ; Bone Regeneration - drug effects ; cementum ; Connective Tissue - physiology ; Dental Cementum - physiology ; Dentistry ; Dogs ; Epithelial Attachment - physiology ; Gels ; insulin-like growth factor ; Insulin-Like Growth Factor I - therapeutic use ; Periapical Tissue - physiology ; Periodontitis - therapy ; Periodontium - physiology ; platelet-derived growth factor ; Platelet-Derived Growth Factor - therapeutic use ; regeneration ; Regeneration - drug effects ; Somatomedins - therapeutic use ; wound healing</subject><ispartof>Journal of clinical periodontology, 1989-09, Vol.16 (8), p.545-548</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4745-86035220e675f6c52ff0da8ec077a585a16749afc8fdc00721dee2e4d8cc8e443</citedby><cites>FETCH-LOGICAL-c4745-86035220e675f6c52ff0da8ec077a585a16749afc8fdc00721dee2e4d8cc8e443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-051X.1989.tb02334.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-051X.1989.tb02334.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2778088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lynch, S. E.</creatorcontrib><creatorcontrib>Williams, R. C.</creatorcontrib><creatorcontrib>Poison, A. M.</creatorcontrib><creatorcontrib>Howell, T. H.</creatorcontrib><creatorcontrib>Reddy, M. S.</creatorcontrib><creatorcontrib>Zappa, U. E.</creatorcontrib><creatorcontrib>Antoniades, H. N.</creatorcontrib><title>A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>The combination of platelet‐derived growth factor (PDGF) and insulin‐like growth factor one (IGF‐1) has previously been shown to enhance repair of soft tissue wounds. Here we report initial observations following application of PDGF and IGF‐1 to periodontitis‐affected teeth in beagle dogs, 1 μg of PDGF and IGF‐1 in an aqueous gel was applied to the root surfaces of test teeth following open flap debridement. Control sites received the gel alone. Block biopsies of the teeth and surrounding bone were taken 2 weeks after treatment. Histologic analyses of control specimens revealed a long junctional epithelial attachment, and no new bone or cementum formation. In contrast, growth factor treated sites exhibited significant amounts of new bone and cementum formation. A nearly continuous layer of osteoblasts lined the newly formed bone, and there was a dense cellular “front” at the coronal extent of the new bone. These preliminary results suggest that in vivo application of the combination of PDGF and IGF‐1 may enhance regeneration of the periodontal structures.</description><subject>Alveolar Process - physiology</subject><subject>Animals</subject><subject>bone</subject><subject>Bone Regeneration - drug effects</subject><subject>cementum</subject><subject>Connective Tissue - physiology</subject><subject>Dental Cementum - physiology</subject><subject>Dentistry</subject><subject>Dogs</subject><subject>Epithelial Attachment - physiology</subject><subject>Gels</subject><subject>insulin-like growth factor</subject><subject>Insulin-Like Growth Factor I - therapeutic use</subject><subject>Periapical Tissue - physiology</subject><subject>Periodontitis - therapy</subject><subject>Periodontium - physiology</subject><subject>platelet-derived growth factor</subject><subject>Platelet-Derived Growth Factor - therapeutic use</subject><subject>regeneration</subject><subject>Regeneration - drug effects</subject><subject>Somatomedins - therapeutic use</subject><subject>wound healing</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1vEzEQhi0EKqHwE5AsDtx2sdfrtZcLKmlpqSI-xFdvlmOPW6eOHewNTf99N02UO3OZwzvvM9KD0BtKajrOu0VNO0IqwulVTXvZ18OcNIy19eYJmhyip2hCGGFV14v-OXpRyoIQKhhjR-ioEUISKSfInGCTlnMf9eBTxMnhVdADBBgqC9n_A4t1tNjHsg4-VsHfAr7O6W64wU6bIeWCId7oaKDg1VhINsVBB5zhGiLkR-pL9MzpUODVfh-jX5_Ofk4vqtnX88_Tk1llWtHySnaE8aYh0AnuOsMb54jVEgwRQnPJNe1E22tnpLOGENFQC9BAa6UxEtqWHaO3O-4qp79rKINa-mIgBB0hrYsSPe2blvTj4fvdocmplAxOrbJf6nyvKFFbw2qhthrVVqPaGlZ7w2ozll_vv6znS7CH6l7pmH_Y5Xc-wP1_kNXl9NsZb_lIqHYEXwbYHAg636pOMMHVny_n6vfVx9PZ91OmfrAHMMudaA</recordid><startdate>198909</startdate><enddate>198909</enddate><creator>Lynch, S. E.</creator><creator>Williams, R. C.</creator><creator>Poison, A. M.</creator><creator>Howell, T. H.</creator><creator>Reddy, M. S.</creator><creator>Zappa, U. E.</creator><creator>Antoniades, H. N.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198909</creationdate><title>A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration</title><author>Lynch, S. E. ; Williams, R. C. ; Poison, A. M. ; Howell, T. H. ; Reddy, M. S. ; Zappa, U. E. ; Antoniades, H. 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E.</creatorcontrib><creatorcontrib>Williams, R. C.</creatorcontrib><creatorcontrib>Poison, A. M.</creatorcontrib><creatorcontrib>Howell, T. H.</creatorcontrib><creatorcontrib>Reddy, M. S.</creatorcontrib><creatorcontrib>Zappa, U. E.</creatorcontrib><creatorcontrib>Antoniades, H. N.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynch, S. E.</au><au>Williams, R. C.</au><au>Poison, A. M.</au><au>Howell, T. H.</au><au>Reddy, M. S.</au><au>Zappa, U. E.</au><au>Antoniades, H. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>1989-09</date><risdate>1989</risdate><volume>16</volume><issue>8</issue><spage>545</spage><epage>548</epage><pages>545-548</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>The combination of platelet‐derived growth factor (PDGF) and insulin‐like growth factor one (IGF‐1) has previously been shown to enhance repair of soft tissue wounds. Here we report initial observations following application of PDGF and IGF‐1 to periodontitis‐affected teeth in beagle dogs, 1 μg of PDGF and IGF‐1 in an aqueous gel was applied to the root surfaces of test teeth following open flap debridement. Control sites received the gel alone. Block biopsies of the teeth and surrounding bone were taken 2 weeks after treatment. Histologic analyses of control specimens revealed a long junctional epithelial attachment, and no new bone or cementum formation. In contrast, growth factor treated sites exhibited significant amounts of new bone and cementum formation. A nearly continuous layer of osteoblasts lined the newly formed bone, and there was a dense cellular “front” at the coronal extent of the new bone. These preliminary results suggest that in vivo application of the combination of PDGF and IGF‐1 may enhance regeneration of the periodontal structures.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2778088</pmid><doi>10.1111/j.1600-051X.1989.tb02334.x</doi><tpages>4</tpages></addata></record> |
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| issn | 0303-6979 1600-051X |
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| subjects | Alveolar Process - physiology Animals bone Bone Regeneration - drug effects cementum Connective Tissue - physiology Dental Cementum - physiology Dentistry Dogs Epithelial Attachment - physiology Gels insulin-like growth factor Insulin-Like Growth Factor I - therapeutic use Periapical Tissue - physiology Periodontitis - therapy Periodontium - physiology platelet-derived growth factor Platelet-Derived Growth Factor - therapeutic use regeneration Regeneration - drug effects Somatomedins - therapeutic use wound healing |
| title | A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration |
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