Zinc alters conformation and inhibits biological activities of nerve growth factor and related neurotrophins

A role for Zn 2+ in a variety of neurological conditions such as stroke, epilepsy and Alzheimer's disease has been postulated. In many instances, susceptible neurons are located in regions rich in Zn 2+ where nerve growth factor (NGF) levels rise as a result of insult. Although the interaction...

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Veröffentlicht in:	Nature medicine 1997-08, Vol.3 (8), p.872-878
Hauptverfasser:	Ross, Gregory M., Shamovsky, Igor L., Lawrance, Gail, Solc, Mark, Dostaler, Suzanne M., Jimmo, Sandra L., Weaver, Donald F., Riopelle, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cancer Research Chickens Infectious Diseases Metabolic Diseases Mice Molecular Medicine Nerve Growth Factors - chemistry Nerve Growth Factors - metabolism Nerve Growth Factors - physiology Neurites Neurosciences PC12 Cells Protein Binding Protein Conformation Rats Receptor, Nerve Growth Factor Receptor, trkA - metabolism Receptors, Nerve Growth Factor - metabolism Zinc - physiology
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