Thyroxine induces cyclosporin A‐insensitive, Ca2+‐dependent reversible permeability transition pore in rat liver mitochondria

The effect of thyroxine on Ca2+‐dependent mitochondrial permeability transition has been examined. It is shown that 40 μM thyroxine induces high amplitude swelling and decrease in membrane potential in Ca2+‐loaded rat liver mitochondria, both in the presence and absence of cyclosporin A. Thyroxine‐i...

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Veröffentlicht in:	FEBS letters 1997-07, Vol.412 (1), p.173-178
Hauptverfasser:	Malkevitch, N.V, Dedukhova, V.I, Simonian, R.A, Skulachev, V.P, Starkov, A.A
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4-dinitrophenol adenine nucleotide translocase Adenosine Diphosphate - pharmacology Animals ANT bovine serum albumin BSA Calcium - pharmacology Cyclosporin A Cyclosporine - pharmacology dithioerythritol DNP DTE EGTA Egtazic Acid - pharmacology ethylene glycol-bis(β-aminoethylether)-N,N,N′,N′-tetraacetic acid Intracellular Membranes - drug effects Intracellular Membranes - physiology Intracellular Membranes - ultrastructure Ionophores - pharmacology l-thyroxine Membrane Potentials - drug effects Mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - ultrastructure Mitochondrial Swelling - drug effects MOPS morpholinopropane sulfonate Niacinamide - pharmacology Nigericin - pharmacology Permeability - drug effects Permeability transition pore Rats Thyroxine Thyroxine - pharmacology transmembrane electric potential difference Uncoupling Agents - pharmacology
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